Search
Search Results
-
Metabolic Messengers: ketone bodies
Prospective molecular targets and therapeutic applications for ketone body metabolism have increased exponentially in the past decade. Initially...
-
Insulin and Ketone Bodies
This chapter focuses on insulin in terms of regulation of ketone body synthesis. Since excessive insulin spikes completely shut down the synthesis,...
-
Intermittent fasting and Alzheimer's disease—Targeting ketone bodies as a potential strategy for brain energy rescue
Alzheimer's disease (AD) lacks effective clinical treatments. As the disease progresses, the cerebral glucose hypometabolism that appears in the...
-
Triangulating evidence from observational and Mendelian randomization studies of ketone bodies for cognitive performance
BackgroundKetone bodies (KBs) are an alternative energy supply for brain functions when glucose is limited. The most abundant ketone metabolite,...
-
Ketone bodies: from enemy to friend and guardian angel
AbstractDuring starvation, fasting, or a diet containing little digestible carbohydrates, the circulating insulin levels are decreased. This promotes...
-
Innovations and applications of ketone body monitoring in diabetes care
Ketone bodies, comprising β-hydroxybutyric acid (BHB), acetoacetate (AcAc), and acetone, play a vital role as essential energy substrates. In...
-
Effect of empagliflozin on ketone bodies in patients with stable chronic heart failure
BackgroundRecent studies indicated that sodium glucose cotransporter (SGLT)2 inhibition increases levels of ketone bodies in the blood in patients...
-
Prognostic role of urinary ketone body in patients with sepsis-associated encephalopathy without hepatic failure: a retrospective cohort study
Sepsis-associated encephalopathy (SAE) is defined as a dysfunction of the central nervous system experienced during sepsis with variable clinical...
-
Relationships Between Changes in Serum Ketone Body Levels and Metabolic Effects in Patients with Severe Obesity Who Underwent Laparoscopic Sleeve Gastrectomy
BackgroundSerum ketone bodies increase due to dynamic changes in the lipid metabolisms of patients undergoing bariatric surgery. However, there have...
-
Glia fuel neurons with locally synthesized ketone bodies to sustain memory under starvation
During starvation, mammalian brains can adapt their metabolism, switching from glucose to alternative peripheral fuel sources. In the Drosophila ...
-
Sodium butyrate activates HMGCS2 to promote ketone body production through SIRT5-mediated desuccinylation
Ketone bodies have beneficial metabolic activities, and the induction of plasma ketone bodies is a health promotion strategy. Dietary supplementation...
-
Exogenous Ketone Supplements in Athletic Contexts: Past, Present, and Future
The ketone bodies acetoacetate (AcAc) and β-hydroxybutyrate (βHB) have pleiotropic effects in multiple organs including brain, heart, and skeletal...
-
Serum ketone body measurement in patients with diabetic ketoacidosis
BackgroundDiabetic ketoacidosis (DKA) is a critical manifestation in patients with diabetes mellitus. DKA has been conventionally diagnosed by the...
-
Ketogenic diet in refractory migraine: possible efficacy and role of ketone bodies—a pilot experience
IntroductionRefractory migraine is a particularly disabling form of chronic migraine, unresponsive to multiple prophylactic strategies. Ketogenic...
-
Disorders of Ketone Body Metabolism and Transport
Ketone body utilisation is of special importance in times of fasting/starvation or increased energy demand. However, both formation and utilisation...
-
Ketone body levels and its associations with cardiac markers following an acute myocardial infarction: a post hoc analysis of the EMMY trial
BackgroundSodium-glucose co-transporter 2 inhibitors (SGLT2i) have been suggested to exert cardioprotective effects in patients with heart failure,...
-
Lactobacillus rhamnosus GG protects against atherosclerosis by improving ketone body synthesis
AbstractAtherosclerosis (AS) is a major cause of death and morbidity worldwide. There is an increasing amount of evidence that the gut microbiota...
-
-
Ketone body 3-hydroxybutyrate enhances adipocyte function
Ketone bodies, including 3HBA, are endogenous products of fatty acid oxidation, and Hmgcs2 is the first rate-limiting enzyme of ketogenesis. From...
-
Neonatal ketone body elevation regulates postnatal heart development by promoting cardiomyocyte mitochondrial maturation and metabolic reprogramming
Neonatal heart undergoes metabolic conversion and cell cycle arrest preparing for the increased workload during adulthood. Herein, we report that...
