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The role of IGF/IGF-1R signaling in the regulation of cancer stem cells
Cancer stem cells (CSCs) are a group of tumor cells with high tumorigenic ability and self-renewal potential similar to those of normal stem...
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IGF-1-mediated FOXC1 overexpression induces stem-like properties through upregulating CBX7 and IGF-1R in esophageal squamous cell carcinoma
Substantial evidence attests to the pivotal role of cancer stem cells (CSC) in both tumorigenesis and drug resistance. A member of the forkhead box...
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Recombinant expression of IGF-1 and LR3 IGF-1 fused with xylanase in Pichia pastoris
AbstractInsulin-like growth factor-1 (IGF-1) is a pleiotropic protein hormone and has become an attractive therapeutic target because of its multiple...
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IGF-Binding Proteins and Their Proteolysis as a Mechanism of Regulated IGF Release in the Nervous Tissue
AbstractInsulin-like growth factors 1 and 2 (IGF-1 and IGF-2) play a key role in the maintenance of the nervous tissue viability. IGF-1 and IGF-2...
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IGF-1 Combined with OPN Promotes Neuronal Axon Growth in Vitro Through the IGF-1R/Akt/mTOR Signaling Pathway in Lipid Rafts
This study aims to investigate the effect of insulin-like growth factor 1 (IGF-1) combined with osteopontin (OPN) on the protein expression levels...
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IGF-1’s protective effect on OSAS rats’ learning and memory
PurposePatients with obstructive sleep apnea syndrome (OSAS) frequently experience cognitive dysfunction, which may be connected to chronic...
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IGF-1R targeting in cancer – does sub-cellular localization matter?
The insulin-like growth factor receptor (IGF-1R) was among the most intensively pursued kinase targets in oncology. However, even after a slew of...
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IGF-1R mediates crosstalk between nasopharyngeal carcinoma cells and osteoclasts and promotes tumor bone metastasis
BackgroundNasopharyngeal carcinoma (NPC) poses a significant health burden in specific regions of Asia, and some of NPC patients have bone metastases...
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An exploratory study of clinical factors associated with IGF-1 and IGFBP-3 in preterm infants
BackgroundDespite advances in parenteral nutrition, postnatal growth failure in very low birthweight (VLBW) preterm infants is common and associated...
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Genetic Polymorphism of GH and IGF-1 Genes and Body Measurements Traits in Maghrabi Camel
AbstractNonetheless the key roles of growth hormone (GH) and insulin growth factor-1 (IGF-1) genes in livestock growth traits (including body...
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Muscle hypertrophy training does not suppress the GH/IGF axis in young adult males
PurposeThis study aimed to analyze the expression of the IGF type-1 receptor gene (IGF-1r) and IGF-I, GH, testosterone, and IGFBP-3 concentrations in...
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IGF-1 is positively associated with BMI in patients with acromegaly
PurposeAcromegaly is a disorder characterized by IGF-1 excess due to autonomous GH secretion. In individuals without acromegaly, IGF-1 is not only...
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Association of an impaired GH-IGF-I axis with cardiac wasting in patients with advanced cancer
BackgroundGrowth hormone (GH) resistance is characterized by high GH levels but low levels of insulin-like growth factor-I (IGF-I) and growth hormone...
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Insulin and IGF-1 have both overlap** and distinct effects on CD4+ T cell mitochondria, metabolism, and function
Insulin and insulin-like growth factor 1 (IGF-1) are metabolic hormones with known effects on CD4 + T cells through insulin receptor (IR) and IGF-1...
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Cell cycle regulation by ADP and IGF-1 in cultured late develo** glia progenitors of the avian retina
In the avian retina, ADP induces the proliferation of late develo** glia progenitors. Here, we show that in serum-containing retinal cell cultures,...
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GH and IGF-1 in skin interstitial fluid and blood are associated with heat loss responses in exercising young adults
PurposeSweat glands and cutaneous vessels possess growth hormone (GH) and insulin-like growth factor 1 (IGF-1) receptors. Here, we assessed if...
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The Growth Hormone-IGF-1 Axis in Anorexia Nervosa
Anorexia nervosa is a psychiatric disorder characterized by low body weight and serves as a model of chronic human starvation. Humans have evolved...
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The interplay between IGF-1R signaling and Hippo-YAP in breast cancer stem cells
BackgroundBoth IGF-1R/PI3K/AKT/mTOR and Hippo pathways are crucial for breast cancer stem cells (BCSCs). However, their interplay remains unclear.
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Short- and long-term effects of nutritional state on IGF-1 levels in nestlings of a wild passerine
Growth trajectories of young animals are intimately connected to their fitness prospects, but we have little knowledge of growth regulation...
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Very low serum IGF-1 levels are associated with vertebral fractures in adult males with beta-thalassemia major
PurposePatients with beta-thalassemia major (BTM) often develop several endocrine disorders due to chronic iron overload. They are also prone to...
