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Mechanisms and regulation of defensins in host defense
As a family of cationic host defense peptides, defensins are mainly synthesized by Paneth cells, neutrophils, and epithelial cells, contributing to...
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Myelodysplastic neoplasm-associated U2AF1 mutations induce host defense defects by compromising neutrophil chemotaxis
Myelodysplastic neoplasm (MDS) is a hematopoietic stem cell disorder that may evolve into acute myeloid leukemia. Fatal infection is among the most...
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S-nitrosothiol homeostasis maintained by ADH5 facilitates STING-dependent host defense against pathogens
Oxidative (or respiratory) burst confers host defense against pathogens by generating reactive species, including reactive nitrogen species (RNS)....
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Programmed Necrosis in Host Defense
Host control over infectious disease relies on the ability of cells in multicellular organisms to detect and defend against pathogens to prevent...
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The crosstalk between bacteria and host autophagy: host defense or bacteria offense
Xenophagy is a specific selective autophagy for the elimination of intracellular bacteria. Current evidence suggests that the processes for host...
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The chemerin-CMKLR1 axis in keratinocytes impairs innate host defense against cutaneous Staphylococcus aureus infection
The skin is the most common site of Staphylococcus aureus infection, which can lead to various diseases, including invasive and life-threatening...
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The future of recombinant host defense peptides
The antimicrobial resistance crisis calls for the discovery and production of new antimicrobials. Host defense peptides (HDPs) are small proteins...
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Defense and anti-defense mechanisms of bacteria and bacteriophages
In the post-antibiotic era, the overuse of antimicrobials has led to a massive increase in antimicrobial resistance, leaving medical doctors few or...
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The dual antimicrobial and immunomodulatory roles of host defense peptides and their applications in animal production
Host defense peptides (HDPs) are small molecules with broad-spectrum antimicrobial activities against infectious bacteria, viruses, and fungi....
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The DAMP-Driven Host Immune Defense Program Against Pathogens
This chapter, the third chapter of the “Infection” part, presents some aspects of host immune defense against pathogens by focusing on...
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Gasdermin D independent canonical inflammasome responses cooperate with caspase-8 to establish host defense against gastrointestinal Citrobacter rodentium infection
Citrobacter rodentium is an enteropathogen that causes intestinal inflammatory responses in mice reminiscent of the pathology provoked by...
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Long-distance relationships - regulation of systemic host defense against infections by the gut microbiota
Despite compartmentalization within the lumen of the gastrointestinal tract, the gut microbiota has a far-reaching influence on immune cell...
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In Vitro Antiviral Activity of Two Host Defense Peptides Against Human alphaherpesvirus 1
Viral infections are continually emerging with new characteristics and the potential to cause outbreaks or pandemics. Therefore, identification of...
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Pattern-Triggered Immunity and Effector-Triggered Immunity: crosstalk and cooperation of PRR and NLR-mediated plant defense pathways during host–pathogen interactions
The elucidation of the molecular basis underlying plant-pathogen interactions is imperative for the development of sustainable resistance strategies...
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Silicon Induced Defense Mechanisms and Pathways of Host Resistance for Insect Pests of Field and Horticultural Crops
The application of Silicon modulates the plant defense mechanism by signaling secondary defense metabolites activating signal transduction pathways...
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Modulation of the immune response by the host defense peptide IDR-1002 in chicken hepatic cell culture
IDR-1002, a synthetic host defense peptide (HDP), appears to be a potential candidate for the treatment of bacterial infections and the consequent...
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A host defense peptide mimetic, brilacidin, potentiates caspofungin antifungal activity against human pathogenic fungi
Fungal infections cause more than 1.5 million deaths a year. Due to emerging antifungal drug resistance, novel strategies are urgently needed to...
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Host defense peptide-mimicking peptide polymer-based antibacterial hydrogel enables efficient healing of MRSA-infected wounds
Wound infections are a compelling health issue caused by the invasion and proliferation of pathogens in wound sites. Antibiotic-loaded hydrogels are...
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Host Defense Peptides: Multifront Attack on Biofilms
Short, cationic, amphipathic peptides are found as natural antimicrobial agents among all life forms. These natural peptides and their synthetic...
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Host-pathogen interaction between pitaya and Neoscytalidium dimidiatum reveals the mechanisms of immune response associated with defense regulators and metabolic pathways
BackgroundUnderstanding how plants and pathogens regulate each other's gene expression during their interactions is key to revealing the mechanisms...
