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Lung ultrasound score follows the chronic pulmonary insufficiency of prematurity trajectory in early infancy
Extremely preterm birth is associated with a high risk of chronic pulmonary insufficiency of prematurity (CPIP). Lung ultrasound score (LUS) proved...
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Chronic Obstructive Pulmonary Disease (COPD)
Chronic obstructive pulmonary disease (COPD) is defined as a nonhomogeneous lung condition with chronic pulmonary symptoms due to abnormalities of... -
Complications of Prematurity
Prematurity is the primary cause of neonatal death world-wide, and complications of prematurity are inversely proportional to the gestational age at... -
Systemic and Pulmonary Venous Abnormalities
This chapter presents a set of questions and answers related to Systemic and Pulmonary Venous Abnormalities. -
Differential placental CpG methylation is associated with chronic lung disease of prematurity
BackgroundChronic lung disease (CLD) is the most common pulmonary morbidity in extremely preterm infants. It is unclear to what extent prenatal...
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The impact of blood lactic acid levels on retinopathy of prematurity morbidity
BackgroundRetinopathy of prematurity (ROP) is a common disease in premature infants. In recent years, most researchers have used lactic acid as poor...
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Leptin deficiency, a potential mechanism for impaired fetal lung development in uteroplacental insufficiency?
Uteroplacental insufficiency (UPI) is a major cause of fetal growth restriction (FGR). Leptin, an adipokine, has been shown to play a vital role in...
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Frail Children with Chronic Lung Disease
This chapter deals with frail children suffering from a chronic respiratory disease. In the first part of the chapter, we analyzed especially... -
Mid-Systolic Notching of the Pulmonary Valve Doppler Signal is Highly Associated with Pulmonary Hypertension
Mid-systolic notching (MSN) of the pulmonary valve Doppler signal represents a reflected systolic pressure wave from the pulmonary vasculature and is...
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Sphingosine phosphate lyase insufficiency syndrome: a systematic review
BackgroundSphingosine-1-phosphate lyase insufficiency syndrome (SPLIS) or nephrotic syndrome type-14 is caused by biallelic mutations in SGPL1 ....
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Prematurity: Evaluation of Fetal Well-Being and Delivery
We are updating on one of the great obstetrics syndromes – preterm birth – in the areas of prevention, detection, and follow-up with different... -
Persistent Pulmonary Hypertension of the Newborn
I. Description A. Persistent pulmonary hypertension of the newborn (PPHN) is a condition in which pulmonary vascular resistance (PVR) is elevated,... -
The impact of intrauterine growth restriction and prematurity on nephron endowment
In humans born at term, maximal nephron number is reached by the time nephrogenesis is completed — at approximately 36 weeks’ gestation. The number...
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Factors associated with discontinuation of pulmonary vasodilator therapy in children with bronchopulmonary dysplasia-associated pulmonary hypertension
ObjectiveTo evaluate factors associated with discontinuation of pulmonary vasodilator therapy in bronchopulmonary dysplasia-related pulmonary...
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Early cardiac function and death, severe bronchopulmonary dysplasia and pulmonary hypertension in extremely preterm infants
BackgroundAssociation between early cardiac function and neonatal outcomes are scarcely reported. The aim of the current study was to describe this...
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The role of recombinant human CC10 in the prevention of chronic pulmonary insufficiency of prematurity
BackgroundPreterm neonates can develop chronic pulmonary insufficiency of prematurity (CPIP) later in infancy. Recombinant human CC10 protein...
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Prematurity, perinatal inflammatory stress, and the predisposition to develop chronic kidney disease beyond oligonephropathy
Prematurity and perinatal stress, such as intrauterine growth restriction (IUGR) and chorioamnionitis, are pathological processes creating an...
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Acute Pulmonary Infections
Acute lower respiratory infection is a common cause of morbidity in infants and children and, at times, requires intensive care and mechanical... -
Anemia of prematurity: how low is too low?
Anemia of prematurity (AOP) is a common condition with a well-described chronology, nadir hemoglobin levels, and timeline of recovery. However, the...
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Prematurity: Relevant Aspects in the Symptomatic Patient
Spontaneous preterm births occur as a consequence of spontaneous preterm labor or preterm rupture of fetal membranes before the onset of labor....