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Anti-asthmatic Activity of Liriodendrin Against Ovalbumin-Induced Asthma in Mice via Attenuating TNF-α
Asthma is a serious hypersensitive allergic manifestation and frequently becomes life-threatening if not managed well in time. However, the...
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Investigation of the Anti-asthmatic Activity of Solidagenone, In Vitro Toxicity Versus In Silico Studies
Solidagenone, a labdane diterpene isolated from inflorescences of Solidago chilensis Meyen, Asteraceae, was investigated for its anti-inflammatory...
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Triptonide, a Diterpenoid Displayed Anti-Inflammation, Antinociceptive, and Anti-Asthmatic Efficacy in Ovalbumin-Induced Mouse Model
The present study was intended to explore the valuable effects of triptonide on inflammation, asthmatic, and nociceptive. Triptonide possesses...
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Intratracheal administration of mesenchymal stem cells modulates lung macrophage polarization and exerts anti-asthmatic effects
Mesenchymal stem cells (MSCs) possess immunomodulatory properties that have therapeutic potential for the treatment of inflammatory diseases. This...
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Anti-inflammatory and relaxation effects of Ulmus pumilla L. on EGF-inflamed bronchial epithelial and asthmatic bronchial smooth muscle cells
BackgroundUlmus Pumila L. (UPL), the roots of a tree species of elm, has been prescribed for immunity-related diseases, such as dermatitis,...
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Traditional Plants with Anti-asthmatic Potential
Aerva lanata L. is a medicinal plant related to the Amaranthaceae family. It is mainly seen growing along roadside and most commonly identified by... -
Anti-IL-5 Pathway Agents in Eosinophilic-Associated Disorders Across the Lifespan
Monoclonal antibodies targeting interleukin (IL)-5 pathways have revolutionized the treatment expectations for eosinophilic-associated conditions,...
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Role of Dendrimers in Management of Allergic Airway Diseases
Dendrimers are three-dimensional polymers that are characterized by their precisely structured hyper-branches and present a cutting-edge polymeric... -
Metabolite profiling and transcriptomic analyses demonstrate the effects of biocontrol agents on alkaloid accumulation in Fritillaria thunbergii
BackgroundDuring Fritillaria thunbergii planting, pests and diseases usually invade the plant, resulting in reduced yield and quality. Previous...
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Effectiveness and economic impact of Dupilumab in asthma: a population-based cohort study
RationaleSevere asthma is burdened by relevant socio-economic and clinical impact. Randomized controlled trials on Dupilumab showed efficacy and a...
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Lipopeptide Biosurfactant Produced by Acinetobacter junii B6 Attenuates Lung Inflammatory, Oxidative, and Histopathological Alterations due to Asthma in Rats
The two main characteristics of asthma pathogenesis are severe inflammation and excessive oxidative stress production. Biosurfactant (BS), as...
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Moringa oleifera and Its Biochemical Compounds: Potential Multi-targeted Therapeutic Agents Against COVID-19 and Associated Cancer Progression
The Coronavirus disease-2019 (COVID-19) pandemic is a global concern, with updated pharmacological therapeutic strategies needed. Cancer patients...
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Allergic asthma is a risk factor for human cardiovascular diseases
Asthma is an allergic airway disease in which type 2-mediated inflammation has a pathogenic role. Cardiovascular diseases (CVDs) are type 1-dominant...
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Cutaneous Adverse Reactions to Biologic Agents
The usage of targeted biologic agents in the form of monoclonal antibodies (mAbs) is rapidly expanding in the treatment of neoplastic, autoimmune,... -
Recent Advances in the Biological Significance of Xanthine and its Derivatives: A Review
Xanthine is the most ubiquitous heterocyclic aromatic compound and have attracted much synthetic interest due to their numerous pharmacological...
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Long-term efficacy of anti-IL-4 receptor antibody in a patient with aspirin-exacerbated respiratory disease and IgG4-related disease
BackgroundAspirin-exacerbated respiratory disease (AERD) and IgG4-related disease (IgG4RD) share a common pathway of Th2-mediated immune mechanism;...
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Airways Relaxant and Antiasthmatic Activity of Aconitum heterophyllum Wall ex Royle. Roots: A Mechanistic Insight
Aconitum heterophyllum Wall ex Royle. (Ranunculaceae) is a traditional medicinal herb that has shown extensive pharmacological potential to treat...
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Role of natural P-gp inhibitor in the effective delivery for chemotherapeutic agents
Multi-drug resistance has shown to be one of the leading threats faced currently in many chemotherapeutic agents. Permeability glycoprotein (P-gp) is...
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The journey of boswellic acids from synthesis to pharmacological activities
There has been a lot of interest in using naturally occurring substances to treat a wide variety of chronic disorders in recent years. From the gum...
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Polyphenols as possible alternative agents in chronic fatigue: a review
Chronic fatigue syndrome (CFS) is a pathological state of extreme tiredness that lasts more than six months and may possess an impact on the social,...