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Production and Formulation of Adenovirus Vectors
Adenovirus vectors have attracted considerable interest over the past decade, with ongoing clinical development programs for applications ranging...
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Development of a perfusion process for serum-free adenovirus vector herpes zoster vaccine production
Herpes zoster is caused by reactivation of the varicella zoster virus (VZV). Researching and develo** a herpes zoster vaccine will help to decrease...
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Construction and immune effect of an HPV16/18/58 trivalent therapeutic adenovirus vector vaccine
ObjectiveThis study aims to prepare candidate vaccines for cervical cancer immunotherapy by inserting the fused genes of human papillomavirus...
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Gene therapy for alopecia in type II rickets model rats using vitamin D receptor-expressing adenovirus vector
Type II rickets is a hereditary disease caused by a mutation in the vitamin D receptor (VDR) gene. The main symptoms of this disease are bone...
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Caveats of chimpanzee ChAdOx1 adenovirus-vectored vaccines to boost anti-SARS-CoV-2 protective immunity in mice
AbstractSeveral COVID-19 vaccines use adenovirus vectors to deliver the SARS-CoV-2 spike (S) protein. Immunization with these vaccines promotes...
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Comparative single-cell transcriptomic profile of hybrid immunity induced by adenovirus vector-based COVID-19 vaccines
In this study, antibody response and a single-cell RNA-seq analysis were conducted on peripheral blood mononuclear cells from five different groups:...
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Development of Adenovirus-Based Covid-19 Vaccine Candidate in Indonesia
Covid-19 pandemic has struck worldwide by end of 2019 and the use of various vaccine platforms was one of the main strategies to end this. To meet...
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Lyophilization to enable distribution of ChAdOx1 and ChAdOx2 adenovirus-vectored vaccines without refrigeration
Distribution of vaccines which require refrigerated or frozen storage can be challenging and expensive. The adenovirus vector platform has been...
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Construction of adenovirus vector expressing duck sclerostin and its induction effect on myogenic proliferation and differentiation in vitro
BackgroundBones and muscles originated together from the mesoderm during embryogenesis, and they can influence each other through mechanical...
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Intratumoral delivery of a Tim-3 antibody-encoding oncolytic adenovirus engages an effective antitumor immune response in liver cancer
Background and PurposeThe use of oncolytic viruses as a gene therapy vector is an area of active biomedical research, particularly in the context of...
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Oncolytic adenovirus encoding LHPP exerts potent antitumor effect in lung cancer
LHPP has been shown to be a new tumor suppressor, and has a tendency to be under-expressed in a variety of cancers. Oncolytic virotheray is a...
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A novel recombinant adenovirus expressing apoptin and melittin genes kills hepatocellular carcinoma cells and inhibits the growth of ectopic tumor
HCC is the most common fatal malignancy. Although surgical resection is the primary treatment strategy, most patients are not eligible for resection...
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Short term but highly efficient Cas9 expression mediated by excisional system using adenovirus vector and Cre
Genome editing techniques such as CRISPR/Cas9 have both become common gene engineering technologies and have been applied to gene therapy. However,...
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AAV production in stable packaging cells requires expression of adenovirus 22/33K protein to allow episomal amplification of integrated rep/cap genes
Efficient manufacture of recombinant adeno-associated virus (rAAV) vectors for gene therapy remains challenging. Packaging cell lines containing...
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Harnessing adenovirus in cancer immunotherapy: evoking cellular immunity and targeting delivery in cell-specific manner
Recombinant adenovirus (rAd) regimens, including replication-competent oncolytic adenovirus (OAV) and replication-deficient adenovirus, have been...
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Molecular characterisation of fowl adenovirus associated with hydropericardium hepatitis syndrome in broiler and layer breeders in Azerbaijan
BackgroundFowl adenovirus-4 is a causative agent of hydropericardium hepatitis syndrome (HHS) in chickens and has been frequently reported from many...
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Long-term trial of protection provided by adenovirus-vectored vaccine expressing the PPRV H protein
A recombinant, replication-defective, adenovirus-vectored vaccine expressing the H surface glycoprotein of peste des petits ruminants virus (PPRV)...
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Potent antitumor efficacy of human dental pulp stem cells armed with YSCH-01 oncolytic adenovirus
BackgroundSystemic administration of oncolytic adenovirus for cancer therapy is still a challenge. Mesenchymal stem cells as cell carriers have...
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Medicinal Plants Against Human Adenovirus Type 1 Infections: Ethnopharmacology, Chemistry, and Clinical and Preclinical Studies
Adenoviruses are double-stranded DNA viruses responsible for respiratory infections, eye infections, epidemic conjunctivitis, and gastroenteritis in...