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Human Microbiome and Frailty: From Observations of Clinically Relevant Associations to Insights into Biological Mechanisms
Nearly all surfaces of the human body are colonized by communities of microbes such as bacteria, viruses, and fungi. Collectively called microbiota,... -
Using electronic consultation (eConsult) to identify frailty in provider-to-provider communication: a feasibility and validation study
BackgroundFrailty is a complex age-related clinical condition that increases vulnerability to stressors. Early recognition of frailty is challenging....
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Hypertension facilitates age-related diseases. ~ Is hypertension associated with a wide variety of diseases?~
Hypertension, a disease whose prevalence increases with age, induces pathological conditions of ischemic vascular disorders such as cerebral...
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Frailty and Cancer Prognosis
Purpose of ReviewThis review aims to summarize the current evidence regarding the prognostic role of frailty in older patients diagnosed with cancer...
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Two-year longitudinal associations between nutritional status and frailty in community-dwelling older adults: Korean Frailty and Aging Cohort Study
BackgroundKorea is expected to become a super-aged society in 2026, and improving nutritional status, which is directly related to health problems,...
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Inflammatory markers and physical frailty: towards clinical application
Global population aging poses a tremendous burden on the health care system worldwide. Frailty is associated with decreased physical reserve and is...
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Multimodal Omics Approaches to Aging and Age-Related Diseases
Aging is associated with a progressive decline in physiological capacities and an increased risk of aging-associated disorders. An increasing body of...
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The Role of Kynurenine Pathway Metabolites in the Development of Frailty in Older Adults
AbstractFrailty is the main geriatric syndrome, which is closely associated with age-related diseases and aging in general. Being considered the main...
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Frailty detection among primary care older patients through the Primary Care Frailty Index (PC-FI)
The prompt identification of frailty in primary care is the first step to offer personalized care to older individuals. We aimed to detect and...
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Frailty prevalence in 42 European countries by age and gender: development of the SHARE Frailty Atlas for Europe
Comparative frailty prevalence data across European countries is sparse due to heterogeneous measurement methods. The Survey of Health, Ageing and...
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Physical frailty recovery is slower than mental frailty recovery after non-cardiac surgery in older adult patients
PurposeFrailty is characterized by fragility and decline in physical, mental, and social activities; it is commonly observed in older adults. No...
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Sarcopenia and Frailty: A Common Thread Across Multiple Comorbidities
Sarcopenia and frailty share a dynamic interplay, significantly influencing the quality of life and functionality in older adults. Defined by the... -
Healthcare cost expenditures associated to frailty and sarcopenia
ObjectivesFrailty and sarcopenia have been related with adverse events, including hospitalization. However, its combined effect with...
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Metabolomic characterization of vigor to frailty among community-dwelling older Black and White men and women
Older women and Black individuals are more likely to experience frailty. A metabolomic characterization of frailty may help inform more effective...
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A Community-Based Model for Detecting and Managing Frailty
Frailty is common in the older population. It represents an increased vulnerability to adverse health outcomes and consumes substantial health and... -
Genetic predisposition to smoking in relation to the risk of frailty in ageing
Frailty causes emerging global health burden due to its high prevalence and mortality. In this study, we used Mendelian randomization (MR) approach...
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Frailty in Children with Oncological Disease
Frailty in children with oncological diseases is evident during the diagnostic phase, therapeutic process, and also follow-up. Children with cancer... -
Assessing the relationship between multimorbidity, NCD configurations, frailty phenotypes, and mortality risk in older adults
BackgroundOlder adults are increasingly susceptible to prolonged illness, multiple chronic diseases, and disabilities, which can lead to the...
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Multimodal exercise training to reduce frailty in people with multiple sclerosis: study protocol for a pilot randomized controlled trial
BackgroundFrailty, a syndrome characterized by decreased reserve and resistance to stressors across multiple physiologic systems, is highly prevalent...
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Adaptation of the comprehensive rheumatologic assessment of frailty (CRAF) as a multidimensional frailty screening tool in patients with rheumatoid arthritis in Vietnam
BackgroundIn recent times, there has been acknowledgment of the prevalence of frailty and pre-frailty among individuals with rheumatoid arthritis...