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Luteolin alleviates inorganic mercury-induced liver injury in quails by resisting oxidative stress and promoting mercury ion excretion
Background
Inorganic mercury is a well-known toxic substance that can cause oxidative stress and liver damage. Luteolin (Lut) is a kind of natural...
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Photoprotective effects of Sargassum thunbergii on ultraviolet B-induced mouse L929 fibroblasts and zebrafish
BackgroundChronic exposure to ultraviolet B (UVB) causes a series of adverse skin reactions, such as erythema, sunburn, photoaging, and cancer, by...
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NF-κB in biology and targeted therapy: new insights and translational implications
NF-κB signaling has been discovered for nearly 40 years. Initially, NF-κB signaling was identified as a pivotal pathway in mediating inflammatory...
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Targeting the Mitochondrion in Diabetic Neuropathy
Dysfunction of mitochondria and signaling pathways related to their function can lead to diabetic peripheral neuropathy, and understanding these...
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Carbon Monoxide Preserves Cellular Integrity and Intestinal Mucosal Barrier Function After Intestinal Transplantation
Intestinal transplantation is a viable life-saving intervention solely reserved for patients with end-stage intestinal failure when total parenteral...
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Dahuang Zhechong Pill Alleviates Liver Fibrosis Progression by Regulating p38 MAPK/NF-κ B/TGF-β1 Pathway
ObjectiveTo explore the effect and mechanism of Dahuang Zhechong Pill (DHZCP) on liver fibrosis.
MethodsLiver fibrosis cell model was induced by...
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Rezeptoren und Signaltransduktion
Einzeller reagieren auf gewisse Stoffe in ihrer Umgebung, sie können z. B. Lockstoffe einer anderen Zelle wahrnehmen und sich darauf zu bewegen...
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Secoemestrin C Ameliorates Psoriasis-like Skin Inflammation in Mice by Suppressing the TNF-α/NF-κB Signaling Pathway
ObjectiveSecoemestrin C (SC), an epitetrathiodioxopiperazine isolated from Aspergillus nidulans , has been previously reported to have...
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Acetate ameliorates ovarian mitochondrial dysfunction in letrozole-induced polycystic ovarian syndrome rat model by improving mitofusin-2
Androgen excess and metabolic abnormality largely contribute to the pathogenesis of polycystic ovarian syndrome (PCOS), which primarily precipitates...
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Inhibition of ANXA2 regulated by SRF attenuates the development of severe acute pancreatitis by inhibiting the NF-κB signaling pathway
BackgroundAcute pancreatitis (AP) is an inflammatory process of the pancreas resulting from biliary obstruction or alcohol consumption....
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Role of Herbal Medicines for the Treatment of Chronic Kidney Disease
The use of herbal medicines has tremendously increased globally and in developed countries over the past decades. Nowadays, several herbal medicines...
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GW842166X Alleviates Osteoarthritis by Repressing LPS-mediated Chondrocyte Catabolism in Mice
ObjectiveTo explore the role and underlying mechanism of GW842166X on osteoarthritis and osteoarthritis-associated abnormal catabolism.
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Cigarette smoke-associated inflammation impairs bone remodeling through NFκB activation
BackgroundCigarette smoking constitutes a major lifestyle risk factor for osteoporosis and hip fracture. It is reported to impair the outcome of many...
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Baicalin Antagonizes Prostate Cancer Stemness via Inhibiting Notch1/NF-κB Signaling Pathway
ObjectiveTo investigate the molecular mechanisms underlying the effect of baicalin on prostate cancer (PCa) progression both in vivo and in vitro .
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Emodin Inhibits Lipopolysaccharide-Induced Inflammation by Activating Autophagy in RAW 264.7 Cells
ObjectiveTo investigate the effects of emodin on inflammation and autophagy in lipopolysaccharide (LPS)-induced RAW 264.7 macrophages and reveal its...
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The interaction of O-GlcNAc-modified NLRX1 and IKK-α modulates IL-1β expression in M1 macrophages
NOD-like receptor (NLR)X1 (NLRX1) is a negative regulator of inflammation by inhibiting nuclear factor- κB ( NF - κB ) signaling and downstream...
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Betulinic acid protects against cardiotoxicity of the organophosphorus pesticide chlorpyrifos by suppressing oxidative stress, inflammation, and apoptosis in rats
The widespread application of organophosphorus (OP) pesticides can affect the environment as well as the animal and human health. Chlorpyrifos (CPF)...
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Hypobaric Hypoxia Aggravates Renal Injury by Inducing the Formation of Neutrophil Extracellular Traps through the NF-κB Signaling Pathway
ObjectiveThe hypersensitivity of the kidney makes it susceptible to hypoxia injury. The involvement of neutrophil extracellular traps (NETs) in renal...
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A STIR nucleic acid drug delivery system for stirring phenotypic switch of microglia in Parkinson’s disease treatments
Neuroinflammation is one of the three important pathological features in neurodegenerative diseases including Parkinson’s disease (PD). The...
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O-GlcNAcylation Modification in Immune Cells: Potential Therapeutic Implications of Sepsis
O-GlcNAc modification is a glycosylation modification that is commonly observed in nuclear and organelle proteins of cells. In recent years, several...
