Search
Search Results
-
The Effect of Endometriosis on the Quality of Oocytes and Embryos Obtained by IVF
Endometriosis-associated infertility is a consequence of complex pathogenetic interactions occurring in the development and course of disease, owing...
-
An epigenome-wide association study of posttraumatic stress disorder in US veterans implicates several new DNA methylation loci
BackgroundPrevious studies using candidate gene and genome-wide approaches have identified epigenetic changes in DNA methylation (DNAm) associated...
-
A2AR-mediated CXCL5 upregulation on macrophages promotes NSCLC progression via NETosis
Tumor-associated macrophages (TAMs) are abundant in tumors and interact with tumor cells, leading to the formation of an immunosuppressive...
-
Exploring the Pattern of Metabolic Alterations Causing Energy Imbalance via PPARα Dysregulation in Cardiac Muscle During Doxorubicin Treatment
Cardiotoxicity by anthracycline antineoplastic drug doxorubicin is one of the systemic toxicity of the cardiovascular system. The mechanism...
-
RNA-Seq transcriptome profiling of Nile rat livers reveals novel insights on the anti-diabetic mechanisms of Water-Soluble Palm Fruit Extract
Water-Soluble Palm Fruit Extract (WSPFE) has been shown to confer anti-diabetic effects in the Nile rat (NR) ( Arvicanthis niloticus ). Liquid and...
-
-
Crosstalk of hepatocyte nuclear factor 4a and glucocorticoid receptor in the regulation of lipid metabolism in mice fed a high-fat-high-sugar diet
BackgroundHepatocyte nuclear factor 4α (HNF4α) and glucocorticoid receptor (GR), master regulators of liver metabolism, are down-regulated in fatty...
-
A neutrophil extracellular traps-related classification predicts prognosis and response to immunotherapy in colon cancer
Neutrophil extracellular traps (NETs) have been categorized as a form of inflammatory cell death mode of neutrophils (NETosis) involved in natural...
-
Cytokimera GIL-11 rescued IL-6R deficient mice from partial hepatectomy-induced death by signaling via non-natural gp130:LIFR:IL-11R complexes
All except one cytokine of the Interleukin (IL-)6 family share glycoprotein (gp) 130 as the common β receptor chain. Whereas Interleukin (IL-)11...
-
Obesity-associated microbiomes instigate visceral adipose tissue inflammation by recruitment of distinct neutrophils
Neutrophils are increasingly implicated in chronic inflammation and metabolic disorders. Here, we show that visceral adipose tissue (VAT) from...
-
Comparative analysis of methods to reduce activation signature gene expression in PBMCs
Preserving the in vivo cell transcriptome is essential for accurate profiling, yet factors during cell isolation including time ex vivo and...
-
Involvement of Ferroptosis in Lupus Nephritis
Lupus nephritis (LN) is one of the most common severe organ manifestations of systemic lupus erythematosus (SLE). LN is often associated with a poor...
-
Adipose Tissue Lipid Metabolism During Exercise
Adipose tissue-derived fatty acids are the primary source of energy during low-intensity exercise. Although the relative contribution of fat to...
-
Epigenome-wide meta-analysis of PTSD symptom severity in three military cohorts implicates DNA methylation changes in genes involved in immune system and oxidative stress
Epigenetic factors modify the effects of environmental factors on biological outcomes. Identification of epigenetic changes that associate with PTSD...
-
Diurnal retinal and choroidal gene expression patterns support a role for circadian biology in myopia pathogenesis
The prevalence of myopia (nearsightedness) is increasing to alarming levels, but its etiology remains poorly understood. Because both laboratory and...
-
Points of Significance: Principal Component Analysis for Biocentric Data Visualization
Driven by resolving power of scRNA-seq analysis, multiple studies highlighted complexity and hierarchy of adipose-derived mesenchymal stem cells....
-
Genome-wide DNA methylation status of Mongolians exhibits signs of cellular stress response related to their nomadic lifestyle
BackgroundEpigenetics is crucial for connecting environmental stresses with physiological responses in humans. Mongolia, where nomadic livestock...
-
Identification of Key Genes and Potential Pathways Associated with Mastitis Induced by E. coli
Mastitis is one of the most important diseases of dairy cattle. It is an infectious disease leading to an inflammatory reaction in the cow's mammary...
-
Characterization of a lipid droplet and endoplasmic reticulum stress related gene risk signature to evaluate the clinical and biological value in hepatocellular carcinoma
IntroductionLipid metabolism and endoplasmic reticulum (ER) stress play an important role in the progression and metastasis of hepatocellular...
-
The ontogenic gonadal transcriptomes provide insights into sex change in the ricefield eel Monopterus albus
BackgroundThe ricefield eel is a freshwater protogynous hermaphrodite fish and has become an important aquaculture species in China. The sex change...
