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Healthcare trajectory of critically ill patients with necrotizing soft tissue infections: a multicenter retrospective cohort study using the clinical data warehouse of Greater Paris University Hospitals
BackgroundNecrotizing skin and soft tissue infections (NSTIs) are rare but serious and rapidly progressive infections characterized by necrosis of...
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Skin and Soft Tissue Infections in Pregnancy
Skin and soft tissue infections (SSTIs) are an important cause of morbidity and mortality in pregnant and postpartum women. SSTIs in pregnancy and... -
Approaches to Surgical Debridement in Necrotizing Soft Tissue Infections: Outcomes of an Animated, Interactive Survey
BackgroundNecrotizing soft tissue infections (NSTI) affect long-term quality of life in survivors. Different approaches to debridement may influence...
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Soft Tissue
Soft tissue lesions are common and consist of a wide spectrum of non-neoplastic lesions, benign tumors, and sarcomas. They are frequently encountered... -
Spectrum of imaging findings in soft-tissue necrosis
Soft tissue necrosis can occur at different tissue levels, with numerous underlying causes. In this pictorial review, we highlight myonecrosis, and...
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The interplay between diabetes Mellitus and soft tissue infections in general surgical patients
BackgroundDiabetes mellitus (DM) is a worldwide pandemic affecting 500 million people. It is known to be associated with increased susceptibility to...
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The impact of operative time on the outcomes of necrotizing soft tissue infections: a multicenter cohort study
BackgroundThe primary aim of this study was to identify if there is an association between the operative time of the initial debridement for...
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Concordance of diagnostic modalities in atypical skin and soft tissue infections in hospitalized patients
Skin and soft tissue infections (SSTIs) have high rates of morbidity and mortality worldwide but lack reliable standards for diagnostic workup. As a...
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Necrotizing Fasciitis
Necrotizing soft-tissue infections (NSTIs) are infrequent but associated with a high mortality grade. An accurate diagnosis is difficult in the early... -
Key pathways and genes that are altered during treatment with hyperbaric oxygen in patients with sepsis due to necrotizing soft tissue infection (HBOmic study)
BackgroundFor decades, the basic treatment strategies of necrotizing soft tissue infections (NSTI) have remained unchanged, primarily relying on...
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Murine Soft Tissue Infection Model to Study Group A Streptococcus (GAS) Pathogenesis in Necrotizing Fasciitis
Group A streptococcus (GAS) necrotizing fasciitis (NF) causes high morbidity and mortality despite prompt intravenous administration of antibiotics,... -
The importance of intravenous immunoglobulin treatment in critically ill patients with necrotizing soft tissue infection: a retrospective cohort study
BackgroundNecrotizing soft-tissue infections are infections with high mortality. The use of immunoglobulins within a combination therapy including...
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WSES/GAIS/WSIS/SIS-E/AAST global clinical pathways for patients with skin and soft tissue infections
Skin and soft-tissue infections (SSTIs) encompass a variety of pathological conditions that involve the skin and underlying subcutaneous tissue,...
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Bacterial Infections
Cutaneous bacterial infections are very common and result from bacterial invasion of the skin, near soft tissue, and its appendages. Most skin... -
Temporal trends of skin and soft tissue infections caused by methicillin-resistant Staphylococcus aureus in Gabon
BackgroundMethicillin-resistant Staphylococcus aureus (MRSA) is one of the leading causes of mortality due to bacterial antimicrobial resistance....
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Extensive direct spreading of “groin hit”-related soft tissue infections: a report of three cases
We present fatal extensive soft tissue infections, a consequence of groin heroin injection, in three subjects, who were 27, 34, and 39 years old and...
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Efficacy and safety of omadacycline for treating complicated skin and soft tissue infections: a meta-analysis of randomized controlled trials
ObjectiveIn the present study, we aimed to compare the clinical efficacy and safety of omadacycline (OMC) with its comparators for the treatment of...
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Salmonella typhimurium necrotizing fasciitis: a case report
BackgroundNecrotizing fasciitis is an aggressive disease that causes necrosis in the muscular fascia and subcutaneous tissues. The infection spreads...
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Determinants of Mortality in Necrotizing Soft Tissue Infections
BackgroundNecrotizing soft tissue infections (NSTI) are frequently encountered, with a high mortality despite advances in health care.
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Impact of prior antibiotic therapy on severe necrotizing soft-tissue infections in ICU patients: results from a French retrospective and observational study
Necrotizing soft-tissue infection (NSTI) is a life-threatening pathology that often requires management in intensive care unit (ICU). Therapies...