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Comparison of reversed-phase, hydrophilic interaction, and porous graphitic carbon chromatography columns for an untargeted toxicometabolomics study in pooled human liver microsomes, rat urine, and rat plasma
IntroductionUntargeted metabolomics studies are expected to cover a wide range of compound classes with high chemical diversity and complexity. Thus,...
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Solute–Solvent Interactions in Hydrophilic Interaction Liquid Chromatography: Characterization of the Retention in a Silica Column by the Abraham Linear Free Energy Relationship Model
The Abraham linear free energy relationship model has been used to characterize a hydrophilic interaction liquid chromatography (HILIC) silica column...
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Hydrophilic interaction chromatography-type sorbent prepared by the modification of methacrylate-base resin with polyethyleneimine for solid-phase extraction of polar compounds
Hydrophilic interaction chromatography (HILIC)-type sorbents were newly developed for the solid-phase extraction (SPE) of polar compounds. Two...
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Phosphorus-doped deep eutectic solvent-derived carbon dots-modified silica as a mixed-mode stationary phase for reversed-phase and hydrophilic interaction chromatography
In this work, phosphorus-doped carbon dots (P-DESCDs) were successfully prepared using choline chloride/lactic acid type deep eutectic solvent and...
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Lipidomics Study of Fishes Using Hydrophilic Interaction Chromatography and Mass Spectrometry
Lipids are closely related to biological mechanisms with their critical role in membrane structures, energy storage, and signaling. Therefore,...
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Untargeted Metabolomics Based on Liquid Chromatography–Mass Spectrometry for the Analysis of Plasma and Erythrocyte Samples in Childhood Obesity
The circulating metabolome of human peripheral blood provides valuable information to investigate the molecular mechanisms underlying the development...
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Silica microparticles modified with ionic liquid bonded chitosan as hydrophilic moieties for preparation of high-performance liquid chromatographic stationary phases
Two novel stationary phases, 1-(4-bromobutyl)-3-methylimidazolium bromide bonded chitosan modified silica and 1-(4-bromobutyl)-3-methylimidazolium...
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Application of Multicomponent Two-Phase Systems in Liquid–Liquid Chromatography
A review of the literature data on the application of multicomponent two-phase systems in liquid–liquid chromatography with free steady phase is...
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Ionizable Cyclofructan 6-Based Stationary Phases for Hydrophilic Interaction Liquid Chromatography Using Superficially Porous Particles
One of the challenges of hydrophilic interaction liquid chromatography (HILIC) is the development of hydrolytically stable stationary phases. In this...
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Utilization of Hydrophilic Imidazolium-Based Ionic Liquid as an Eco-Friendly Modifier for the Simultaneous Liquid Chromatographic Determination of Statins in Pharmaceutical Tablets
AbstractStatins, also known as HMG-CoA reductase inhibitors, are utilized for the treatment of hypercholesterolemia. A novel green modifier,...
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Automated liquid–liquid deep eutectic solvents based microextraction procedure for determination of acrylamide in foodstuffs by high-performance liquid chromatography with ultraviolet detection
For the rapid and efficient determination of acrylamide in food products by HPLC-UV, an environmentally friendly analytical approach has been...
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Liquid Chromatography and Capillary Electrophoresis Analysis of 2AA-Labeled O-Glycans
To reveal O-glycan structures in mucins, it is necessary to release covalently bound O-glycans from the polypeptide backbone and derivatize to a form...
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Simultaneous determination of nereistoxin insecticides in foods of animal origins by combining pH-dependent reversible partitioning with hydrophilic interaction chromatography-mass spectrometry
Although nereistoxin insecticides (NIs) are banned for animal husbandry operations, they are still used because of their high insecticidal...
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Comparison of human IgG glycopeptides separation using mixed-mode hydrophilic interaction/ion-exchange liquid chromatography and reversed-phase mode
Glycoproteomics is a challenging branch of proteomics because of the micro- and macro-heterogeneity of protein glycosylation. Hydrophilic interaction...
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Liquid Chromatography in Bioanalysis
The extreme complexity of biological samples still poses a challenge in the resolution, identification, and quantification of their compounds. Liquid...
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Hydrophilic retention mechanism of imidazoline and serotonin receptor ligands in thin-layer and high-performance liquid chromatography systems
We investigated and compared hydrophilic retention mechanism (HILIC) of ten compounds (imidazoline and serotonin receptor ligands) in the thin-layer...
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Comprehensive two-dimensional liquid chromatography
Despite progress in hardware and column technology, the complexity and heterogeneity of many samples still pose a challenge for state-of-the-art 1D...
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Homogeneous Liquid–Liquid Microextraction
The development of liquid phase microextraction methods has led to significant progress in extraction processes by overcoming several challenges...
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Precursor Carboxy-silica for Functionalization With Interactive Ligands. II. Carbodiimide Assisted Preparation of Silica Bonded Stationary Phases with D-glucamine for Hydrophilic Interaction Liquid Chromatography
A precursor carboxy-silica support was introduced for grafting a retentive polar ligand, namely D-glucamine, for use in hydrophilic interaction...
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Combination of switchable hydrophilic solvent liquid–liquid microextraction with QuEChERS for trace determination of triazole fungicide pesticides by GC–MS
This work first proposed a novel green and efficient method based on Quick, Easy, Cheap, Efficient, Rugged, and Safe pretreatment (QuEChERS) combined...
