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Toxicological effect of acetaminophen, metamizole, and nimesulide cocktail on early development of zebrafish
BackgroundSeveral countries’ most incorrectly discarded medicines are acetaminophen (ACM), metamizole (MTZ), and nimesulide (NMS). These xenobiotics...
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CONUT score as a predictor for anamorelin efficacy in patients with cancer cachexia receiving chemotherapy
BackgroundAnamorelin is expected to improve cancer cachexia by increasing lean body mass (LBM) due to increased appetite and protein synthesis....
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Influence of ensitrelvir or nirmatrelvir/ritonavir on tacrolimus clearance in kidney transplant recipients: a single-center case series
BackgroundAmong the oral antivirals used for treating patients with mild-to-moderate novel coronavirus disease 2019 (COVID-19),...
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Increasing Diversity, Equity, Inclusion, and Accessibility in Rare Disease Clinical Trials
Diversity, equity, inclusion, and accessibility (DEIA) are foundational principles for clinical trials and medical research. In rare diseases...
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Optimizing open-angle glaucoma risk assessment in patients with retinal vein occlusions
PurposeTo evaluate factors associated with the diagnosis of open-angle glaucoma (OAG) after a retinal vein occlusion (RVO).
DesignRetrospective,...
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Dual phage-incorporated electrospun polyvinyl alcohol-eudragit nanofiber matrix for rapid healing of diabetic wound infected by Pseudomonas aeruginosa and Staphylococcus aureus
Diabetic wound healing remains a healthcare challenge due to co-occurring multidrug-resistant (MDR) bacterial infections and the constraints...
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Aqueous shunt exposure repair: outcomes and risk factors for recurrence
ObjectiveTo investigate the outcomes of aqueous shunt exposure repair and to identify risk factors for recurrent exposure after surgical repair.
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The 2023 Doyne Lecture—a cornea care system: evolution
Blindness and visual impairment affect the quality of life of the individual and their family members. Corneal opacities are a key cause of vision...
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Implementing immediate sequential bilateral cataract surgery at Buckinghamshire Healthcare NHS Trust
Background/ObjectivesImmediate sequential bilateral cataract surgery (ISBCS) was first introduced into NICE guidelines in 2017. In this approach,...
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Risks and regulation of rubber scattershot in Switzerland: a narrative review
Multiple kinetic impact projectiles (KIPs) are responsible for most eye injuries by crowd-control weapons. This review aims to outline an...
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Chitosan/carbomer nanoparticles- laden in situ gel for improved ocular delivery of timolol: in vitro, in vivo, and ex vivo study
Due to the small capacity of the eye cavity and the rapid drainage of liquid into the nasolacrimal duct, patients must frequently administer the...
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Synergistic effects of thermosensitive liposomal doxorubicin, mild hyperthermia, and radiotherapy in breast cancer management: an orthotopic mouse model study
Liposome formulations of the cancer drug doxorubicin have been developed to address the severe side effects that result from administration of this...
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Efficacy of a Zn-based metalorganic framework doped with benznidazole on acute experimental Trypanosoma cruzi infection
Metal-Organic Frameworks (MOFs) have been shown to enhance the activity of encapsulated compounds by facilitating their passage across cell...
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Preparation, characterization, oral bioavailability, and pharmacodynamic study of eugenol-porous silica solidified powder
Eugenol possesses anti-inflammatory and antioxidant properties, and may serve as a potential therapeutic agent for hepatic fibrosis. However, the...
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Universal eye screening: perinatal risk factors and ocular abnormalities in 1795 newborns not meeting retinopathy of prematurity criteria
ObjectivesThis prospective cohort study aimed to investigate the ocular outcomes of universal eye screening in newborns and assess the relationship...
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The effect of four loading intravitreal aflibercept injections on macular fluid in treatment-naïve neovascular age-related macular degeneration
PurposeTo evaluate the effect of four versus three loading aflibercept injections on macular fluid resolution and visual acuity (VA) in exudative...
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Endpoints for Pharmacotherapy Trials for Alcohol Use Disorder
Alcohol use disorder (AUD) is a debilitating disorder, yet currently approved pharmacotherapies to treat AUD are under-utilized. The three...
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A Longitudinal Analysis of the Relationship Between Different Levels of Cognitively Stimulating Leisure Activity and Cognitive Function Among Older Adults with MCI
The aim of this study was to examine the longitudinal relationship between different levels of cognitively stimulating leisure activity (CSLA)...
