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Knockout Transporter Cell Lines to Assess Substrate Potential Towards Efflux Transporters
P-glycoprotein (P-gp), breast cancer resistance protein (BCRP) and multidrug resistance transporter 2 (MRP2) are efflux transporters involved in the...
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Glycogenolysis-Induced Astrocytic Ser**1 Expression Regulates Neuroinflammatory Effects on Hippocampal neuron
The bacterial pathogen, lipopolysaccharide (LPS), elicits microglial response and induces cytokine secretion that subsequently activates astrocytes....
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Greater Self-reported Health is Associated with Lower Disgust: Evidence for Individual Calibration of the Behavioral Immune System
A key theoretical component of the behavioral immune system is its functional flexibility, where an individual’s reaction to pathogenic stimuli is...
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Combining app-based behavioral therapy with electronic cigarettes for smoking cessation: a study protocol for a single-arm mixed-methods pilot trial
BackgroundCigarette smoking remains a leading cause of preventable illness and death, underscoring the need for effective evidence-based smoking...
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Identification of the Core Characteristics of Vulnerable/Hypersensitive Narcissism and its Association with the Dark Triad in a Large International Sample: A Network Analysis Study
The current paper aimed to investigate the network structure and centrality indexes of hypersensitive narcissism using the hypersensitive Narcissism...
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The Broad Spectrum of Responses to Oxidative Stress in Proliferating Cells
Proliferating mammalian cells exhibit a broad spectrum of responses to oxidative stress, depending on the stress level encountered. Very low levels...
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Low Molecular Weight Antioxidants
Low molecular weight antioxidants are an important part of the antioxidative defense mechanisms of cells and organisms. This chapter gives a short...
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Environmental Oxidative Stress – Environmental Sources of ROS
Environmental factors are known sources for oxidative stress. In consequence of the numerous influences that define our environment, environmental...
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Endogenous Oxidant-Generating Systems
Although organisms respiring air oxygen use their energy sources in an optimal way they are threatened by the compulsory formation of reactive oxygen...
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Glutathione
Glutathione is the most abundant non-protein thiol in cells. It is a tripeptide with two important structural features: the thiol group and the...
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Modulation of Cellular Signaling Processes by Reactive Oxygen Species
Exposure of cells to reactive oxygen species (ROS) may result not only in cell death by excessive oxidation of biomolecules but also cause the...
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Fibroblast growth factor receptor 4 deficiency in macrophages aggravates experimental colitis by promoting M1-polarization
Objective and designCompelling evidence indicates that dysregulated macrophages may play a key role in driving inflammation in inflammatory bowel...
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Neurological and Psychiatric Clinical Manifestations of Sjögren Syndrome
Purpose of ReviewSjögren Syndrome is a systemic autoimmune disorder that presents mainly with sicca symptoms, but frequently affects other body...
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Investigating the Impact of Intracerebroventricular Streptozotocin on Female Rats with and without Ovaries: Implications for Alzheimer’s Disease
To contribute to research on female models of Alzheimer’s disease (AD), our aim was to study the effect of intracerebroventricular (ICV) injection of...
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Current Topics Regarding the Function of the Medial Temporal Lobe Memory System
The first clear insight that the medial temporal lobe of the human brain was in fact a system of anatomically connected structures that were...
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Diazo and Diazonium DNA Cleavage Agents: Studies on Model Systems and Natural Product Mechanisms of Action
Diazonium salts have been previously used to cleave DNA via generation of carbon centered radicals and cations. Efforts have been made in the...
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Synthesis of Biologically Active Heterocyclic Stilbene and Chalcone Analogs of Combretastatin
Combretastatin A-4 (CA-4, 7) has had a major impact in the field of medicinal chemistry as a potent bioactive molecule that binds to the...
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Overcoming Bacterial Resistance: Role of β-Lactamase Inhibitors
Resistance to modern antibiotics is currently a major health concern in treating infectious diseases. Abuse, overuse, and misuse of antibiotics in...