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Differences in severity of chemotherapy-induced nausea and vomiting between neoadjuvant and adjuvant chemotherapy in patients with breast cancer: analysis of data from two prospective observational studies
PurposeWe assessed the differences in chemotherapy-induced nausea and vomiting (CINV) severity in patients with breast cancer, receiving neoadjuvant...
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Targeting the pancreatic tumor microenvironment by plant-derived products and their nanoformulations
Pancreatic cancer remains a significant health issue with limited treatment options. The tumor stroma, a complex environment made up of different...
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Integrative metagenomic, transcriptomic, and proteomic analysis reveal the microbiota-host interplay in early-stage lung adenocarcinoma among non-smokers
BackgroundThe incidence of early-stage lung adenocarcinoma (ES-LUAD) is steadily increasing among non-smokers. Previous research has identified...
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Rare tumours of the pancreas: monocentric study
PurposeThe biology of rare pancreatic tumours, which differs from that of ductal pancreatic cancer, requires increased attention. Although the...
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Regional Heterogeneity in Intestinal Epithelial Barrier Permeability and Mesenteric Perfusion After Thoracic Spinal Cord Injury
BackgroundSpinal cord injury (SCI) disrupts intestinal barrier function, thereby increasing antigen permeation and leading to poor outcomes. Despite...
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Systematic review: genetic polymorphisms in the pharmacokinetics of high-dose methotrexate in pediatric acute lymphoblastic leukemia patients
Variations in pharmacokinetic responses to high-dose methotrexate are essential for the prognosis and management of toxicity in the treatment of...
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Genome-wide association study on meningioma risk in Japan: a multicenter prospective study
PurposeAlthough meningiomas are the most common primary intracranial tumors, their genetic etiologies have not been fully elucidated. To date, only...
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Inter-zonal epithelial thickness differences for early keratoconus detection using optical coherence tomography
PurposeTo develop and test a parameter for early keratoconus screening by quantifying the localized epithelial thickness differences in keratoconic...
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Targeting CERS6-AS1/FGFR1 axis as synthetic vulnerability to constrain stromal cells supported proliferation in Mantle cell lymphoma
The interaction between stromal and tumor cells in tumor microenvironment is a crucial factor in Mantle cell lymphoma (MCL) progression and therapy...
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CCT6A promotes cell proliferation in colon cancer by targeting BIRC5 associated with p53 status
Chaperonin-containing TCP1 (CCT) is a multi-subunit complex, known to participate the correct folding of many proteins. Currently, the mechanism...
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Optimising a digitally delivered behavioural weight loss programme: study protocol for a factorial cluster randomised controlled trial
BackgroundDigitally delivered weight loss programmes can provide a convenient, potentially cheaper, and scalable treatment option for people who may...
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Genetic association of lipid traits and lipid-related drug targets with normal tension glaucoma: a Mendelian randomization study for predictive preventive and personalized medicine
BackgroundGlaucoma is the leading cause of irreversible blindness worldwide. Normal tension glaucoma (NTG) is a distinct subtype characterized by...
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Explaining Socioeconomic Inequality in Psychological Well-being among Older People: A Comparison between Vietnam and Myanmar
Limited understanding exists regarding the social determinants of psychological well-being inequalities, particularly in develo** countries with...
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Re-administration of platinum-based chemotherapy for recurrent endometrial cancer: an ancillary analysis of the SGSG-012/GOTIC-004/Intergroup study
BackgroundWe previously demonstrated the applicability of the concept of “platinum sensitivity” in recurrent endometrial cancer. Although immune...
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Artificial intelligence in ovarian cancer drug resistance advanced 3PM approach: subtype classification and prognostic modeling
BackgroundOvarian cancer patients’ resistance to first-line treatment posed a significant challenge, with approximately 70% experiencing recurrence...
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An international delphi survey and consensus meeting to define the risk factors for ureteral stricture after endoscopic treatment for urolithiasis
PurposeIatrogenic ureteral strictures (US) after endoscopic treatment for urolithiasis represent a significant healthcare concern. However,...
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Synthesis of Carbon Dots via Microwave-Assisted Process: Specific Sensing of Fe(III) and Antibacterial Activity
Carbon dots synthesized from a renewable and sustainable source of biomass have greater attention in the nanomaterial research field. In the present...
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A comprehensive review on pleiotropic effects and therapeutic potential of soy lecithin
Lecithin is one of the most useful and valuable by-products of the oilseed industry and has long been a crucial component of a wide range of both...
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The Role of Prosocial Behaviour in the Deceleration of Conduct Problem Behaviour
While conduct problem behaviour initiated in early childhood often escalates in frequency and seriousness through adolescence, a notable deceleration...
