Abstract
Lecithin is one of the most useful and valuable by-products of the oilseed industry and has long been a crucial component of a wide range of both food and non-food items. Lecithin obtained from soybean (Soy) is called soy lecithin and is composed of triglycerides, fatty acids, pigments, sterols, steroid glycosides, esters, tocopherols, and carbohydrates. Lecithin serves a variety of industrial purposes in food as well as non-food industries. Soy lecithin has grown in importance as a component of nutraceuticals and food supplements during the past few decades. Soy lecithin primarily consists of phospholipids including phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylinositol (PI), phosphatidylserine (PS) which plays a major role in biological and structural processes such as cellular signalling and membrane transport. Soy lecithin has exceptional biocompatibility and is amphipathic in nature. Because of these special qualities, soy lecithin is best suited to be used as a major pharmacological excipient, and it is broadly used in drug delivery systems. It also has a significant role in medicine as it is an antioxidant, increases biliary secretions, maintains cholesterol levels, storehouse of choline, and supports the synthesis of crucial neurotransmitters involved in memory recall and storage. The core intent of this review is to investigate and update the information on the therapeutic importance of soy lecithin and highlight its various other commercial roles in the pharmaceutical industries and food industries.
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References
Abdul QA, Yu BP, Chung HY, Jung HA, Choi JS (2017) Epigenetic modifications of gene expression by lifestyle and environment. Arch Pharmacal Res 40(11):1219–1237. https://doi.org/10.1007/s12272-017-0973-3
Ablon G, Rotunda AM (2004) Treatment of lower eyelid fat pads using phosphatidylcholine: clinical trial and review. Dermatol Surg 30(3):422–427
Akram R, Ahmad M, Abrar A, Sarfraz RM, Mahmood A (2018) Formulation design and development of matrix diffusion controlled transdermal drug delivery of glimepiride. Drug Des Dev Ther 12:349–364. https://doi.org/10.2147/DDDT.S147082
Amenta F, Battineni G, Traini E, Pallotta G (2020) Choline-containing phospholipids and treatment of adult-onset dementia disorders. In: Martin CR, Preedy RV (eds) Diagnosis and management in dementia. Elsevier, Amsterdam, pp 477–493
Asprea M, Tatini F, Piazzini V, Rossi F, Bergonzi M, Bilia A (2019) Stable, monodisperse, and highly cell-permeating nanocochleates from natural soy lecithin liposomes. Pharmaceutics 11(1):34. https://doi.org/10.3390/pharmaceutics11010034
Bangham AD, Horne RW (1964) Negative staining of phospholipids and their structural modification by surface-active agents as observed in the electron microscope. J Molecul Biol 8(5):660-IN10. https://doi.org/10.1016/S0022-2836(64)80115-7
Belayneh HD, Wehling RL, Cahoon E, Ciftci ON (2018) Lipid composition and emulsifying properties of Camelina sativa seed lecithin. Food Chem 242:139–146. https://doi.org/10.1016/j.foodchem.2017.08.082
Best CH, Huntsman ME (1935) The effect of choline on the liver fat of rats in various states of nutrition. J Physiol 83(3):255–274. https://doi.org/10.1113/jphysiol.1935.sp003227
Bot F, Cossuta D, O’Mahony JA (2021) Inter-relationships between composition, physicochemical properties and functionality of lecithin ingredients. Trends Food Sci Technol 111:261–270. https://doi.org/10.1016/j.tifs.2021.02.028
Brinkman SD, Smith RC, Meyer JS, Vroulis G, Shaw T, Gordon JR, Allen RH (1982) Lecithin and memory training in suspected alzheimer’s disease. J Gerontol 37(1):4–9. https://doi.org/10.1093/geronj/37.1.4
Budai L (2013) Liposomes for topical use: a physico-chemical comparison of vesicles prepared from egg or soy lecithin. Sci Pharm 81(4):1151–1166. https://doi.org/10.3797/scipharm.1305-11
Burgess JW, Neville TA, Rouillard P, Harder Z, Beanlands DS, Sparks DL (2005) Phosphatidylinositol increases HDL-C levels in humans. J Lipid Res 46(2):350–355
Chen L-C, Chen Y-C, Su C-Y, Wong W-P, Sheu M-T, Ho H-O (2016) Development and characterization of lecithin-based self-assembling mixed polymeric micellar (saMPMs) drug delivery systems for curcumin. Sci Rep 6(1):37122. https://doi.org/10.1038/srep37122
Chiang JYL (2002) Bile acid regulation of gene expression: roles of nuclear hormone receptors. Endocr Rev 23(4):443–463. https://doi.org/10.1210/er.2000-0035
Choe J, Choe E (2016) Effect of soy-derived phospholipid on the autoxidation of canola oil in a water/oil emulsion. J Am Oil Chem' Soc 93:1085–1094
Ciji A, Akhtar MS, Tripathi PH, Pandey A, Rajesh M, Kamalam BS (2021) Dietary soy lecithin augments antioxidative defense and thermal tolerance but fails to modulate non-specific immune genes in endangered golden mahseer (Tor putitora) fry. Fish Shellfish Immunol 109:34–40. https://doi.org/10.1016/j.fsi.2020.11.031
Cooke RF, Del Río NS, Caraviello DZ, Bertics SJ, Ramos MH, Grummer RR (2007) Supplemental choline for prevention and alleviation of fatty liver in dairy cattle. J Dairy Sci 90(5):2413–2418. https://doi.org/10.3168/jds.2006-028
Cordle CT (2004) Soy protein allergy: incidence and relative severity. J Nutr 134(5):1213S-1219S. https://doi.org/10.1093/jn/134.5.1213S
Cui L, McClements DJ, Decker EA (2015) Impact of phosphatidylethanolamine on the antioxidant activity of α-tocopherol and trolox in bulk oil. J Agric Food Chem 63(12):3288–3294. https://doi.org/10.1021/acs.jafc.5b00243
Curley R, Banta RA, Garvey S, Holmes JD, Flynn EJ (2021) Biomimetic spherical silica production using phosphatidylcholine and soy lecithin. Appl Nanosci 11(5):1721–1735. https://doi.org/10.1007/s13204-021-01839-y
Damnjanović J, Nakano H, Iwasaki Y (2013) Simple and efficient profiling of phospholipids in phospholipase D-modified soy lecithin by HPLC with charged aerosol detection. J Am Oil Chem Soc 90(7):951–957. https://doi.org/10.1007/s11746-013-2236-x
de Vree JML, Jacquemin E, Sturm E, Cresteil D, Bosma PJ, Aten J, Deleuze J-F, Desrochers M, Burdelski M, Bernard O, Elferink RPJO, Hadchouel M (1998) Mutations in the MDR 3 gene cause progressive familial intrahepatic cholestasis. Proc Natl Acad Sci 95(1):282–287. https://doi.org/10.1073/pnas.95.1.282
Deng L (2021) Current progress in the utilization of soy-based emulsifiers in food applications–a review. Foods 10(6):1354
Dreher F, Walde P, Luisi PL, Elsner P (1996) human skin irritation studies of a lecithin microemulsion gel and of lecithin liposomes. Skin Pharmacol Physiol 9(2):124–129. https://doi.org/10.1159/000211408
Efraim P, Marson GC, Jardim DC, Garcia AO, Yotsuynagi K (2011) Influence of phytosterols addition in the rheology and sensory attributes of dark chocolate. Procedia Food Sci 1:1633–1637
Eros G, Varga G, Varadi R, Czobel M, Kaszaki J, Ghyczy M, Boros M (2008) Anti-inflammatory action of a phosphatidylcholine, phosphatidylethanolamine and N-acylphosphatidylethanolamine-enriched diet in carrageenan-induced pleurisy. Eur Surg Res 42(1):40–48
Ezekiel CI, Bapolisi AM, Walker RB, Krause RWM (2021) Ultrasound-triggered release of 5-fluorouracil from soy lecithin echogenic liposomes. Pharmaceutics 13(6):821. https://doi.org/10.3390/pharmaceutics13060821
Fledrich R, Abdelaal T, Rasch L, Bansal V, Schütza V, Brügger B, Lüchtenborg C, Prukop T, Stenzel J, Rahman RU, Hermes D, Ewers D, Möbius W, Ruhwedel T, Katona I, Weis J, Klein D, Martini R, Brück W, Sereda MW (2018) Targeting myelin lipid metabolism as a potential therapeutic strategy in a model of CMT1A neuropathy. Nat Commun 9(1):3025. https://doi.org/10.1038/s41467-018-05420-0
Franciosoa A, Mastromarino P, Masci A, d’Erme M, Mosca L (2014) Chemistry, stability and bioavailability of resveratrol. Med Chem 10(3):237–245. https://doi.org/10.2174/15734064113096660053
Galarneau A, Renard G, Mureseanu M, Tourrette A, Biolley C, Choi M, Ryoo R, Di Renzo F, Fajula F (2007) Synthesis of sponge mesoporous silicas from lecithin/dodecylamine mixed-micelles in ethanol/water media: a route towards efficient biocatalysts. Microporous Mesoporous Mater 104(1–3):103–114. https://doi.org/10.1016/j.micromeso.2007.01.017
Gándola YB, Pérez SE, Irene PE, Sotelo AI, Miquet JG, Corradi GR, Carlucci AM, Gonzalez L (2014) Mitogenic effects of phosphatidylcholine nanoparticles on MCF-7 breast cancer cells. Biomed Res Int 2014:1–13. https://doi.org/10.1155/2014/687037
Gao H, Wu J, Sun Z, Zhang F, Shi T, Lu K, Qian D, Yin Z, Zhao Y, Qin J, Xue B (2022) Influence of lecithin cholesterol acyltransferase alteration during different pathophysiologic conditions: a 45 years bibliometrics analysis. Front Pharmacol. https://doi.org/10.3389/fphar.2022.1062249
Garcia-Becerra C, Rojas A, Höcht C, Bernabeu E, Chiappetta D, Tevez S, Lucangioli S, Flor S, Tripodi V (2023) Characterization and bioavailability of a novel coenzyme Q10 nanoemulsion used as an infant formula supplement. Int J Pharm 634:122656. https://doi.org/10.1016/j.ijpharm.2023.122656
Gregoriadis G, Leathwood PD, Ryman BE (1971) Enzyme entrapment in liposomes. FEBS Lett 14(2):95–99. https://doi.org/10.1016/0014-5793(71)80109-6
Hammad MA, Müller BW (1998) Increasing drug solubility by means of bile salt–phosphatidylcholine-based mixed micelles. Eur J Pharm Biopharm 46(3):361–367. https://doi.org/10.1016/S0939-6411(98)00037-X
Harris CM, Dysken MW, Fovall P, Davis JM (1983) Effect of lecithin on memory in normal adults. Am J Psychiatry 140(8):1010–1012. https://doi.org/10.1176/ajp.140.8.1010
Hasengschwandtner F (2005) Phosphatidylcholine treatment to induce lipolysis. J Cosmet Dermatol 4(4):308–313
Hellhammer J, Fries E, Buss C, Engert V, Tuch A, Rutenberg D, Hellhammer D (2004) Effects of soy lecithin phosphatidic acid and phosphatidylserine complex (PAS) on the endocrine and psychological responses to mental stress. Stress 7(2):119–126
Hoeller S, Klang V, Valenta C (2008) Skin-compatible lecithin drug delivery systems for fluconazole: effect of phosphatidylethanolamine and oleic acid on skin permeation. J Pharm Pharmacol 60(5):587–591
Hu B, Tian F, Wang G, Zhang Q, Zhao J, Zhang H, Chen W (2015) Enhancement of bile resistance in Lactobacillus plantarum strains by soy lecithin. Lett Appl Microbiol 61(1):13–19. https://doi.org/10.1111/lam.12418
Hu G-L, **ong J, Liu Y, Yang H-J, Hu L-L, Chen P, Wang X, Liao S, Lv T, Liu C-J, Huang P, Lin Q (2022) Effects of lecithin supplementation in feed of different fat levels on serum indexes and liver health of laying hens. Front Physiol. https://doi.org/10.3389/fphys.2022.892585
Idris MHM, Budin SB, OsmanMohamed MJ (2012) Protective role of hibiscus sabdariffa calyx extract against streptozotocin induced sperm damage in diabetic rats. Excli J 11:1611–2156
Jelveh K, Mottaghitalab M, Mohammadi M (2023) Effects of green tea phytosome on growth performance and intestinal integrity under coccidiosis infection challenge in broilers. Poult Sci 102(5):102627. https://doi.org/10.1016/j.psj.2023.102627
Kang EY, Cui F, Kim HK, Nawaz H, Kang S, Kim H, ... Go, GW (2022) Effect of phosphatidylserine on cognitive function in the elderly: a systematic review and meta-analysis. Korean J Food Sci Technol 54(1):52–58
Katariya M, Mehta D (2020). Fabrication of an organogel-based transdermal delivery system of loxoprofen sodium. In: The 1st International electronic conference on pharmaceutics, 20. https://doi.org/10.3390/IECP2020-08645
Kumarathunga PADM, Kalupahana NS, Antonypillai CN (2021) Over-the-counter protein supplement resulting in impaired thyroxine absorption in a hypothyroid patient. Endocrinol Diabetes Metabol Case Rep. https://doi.org/10.1530/EDM-21-0070
Lamireau T, Bouchard G, Yousef IM, Clouzeau-Girard H, Rosenbaum J, Desmoulière A, Tuchweber B (2007) Dietary lecithin protects against cholestatic liver disease in cholic acid-Fed Abcb4− deficient mice. Pediatr Res 61(2):185–190. https://doi.org/10.1203/pdr.0b013e31802d7780
Le NTT, Cao VDu, Nguyen TNQ, Le TTH, Tran TT, Hoang Thi TT (2019) Soy lecithin-derived liposomal delivery systems: surface modification and current applications. Int J Mol Sci 20(19):4706. https://doi.org/10.3390/ijms20194706
Le NTT, Nguyen DTD, Nguyen NH, Nguyen CK, Nguyen DH (2021) Methoxy polyethylene glycol–cholesterol modified soy lecithin liposomes for poorly water-soluble anticancer drug delivery. J Appl Polym Sci 138(7):49858. https://doi.org/10.1002/app.49858
Lee JYJ, Keane MG, Pereira S (2015) Diagnosis and treatment of gallstone disease. Practitioner 259(1783):15–19
Leprohon CE, Blusztajn JK, Wurtman RJ (1983) Dopamine stimulation of phosphatidylcholine (lecithin) biosynthesis in rat brain neurons. Proc Natl Acad Sci 80(7):2063–2066. https://doi.org/10.1073/pnas.80.7.2063
Li J, Wang X, Zhang T, Wang C, Huang Z, Luo X, Deng Y (2015) A review on phospholipids and their main applications in drug delivery systems. Asian J Pharm Sci 10(2):81–98. https://doi.org/10.1016/j.ajps.2014.09.004
Li XZ, Park BK, Hong BC, Ahn JS, Shin JS (2017) Effect of soy lecithin on total cholesterol content, fatty acid composition and carcass characteristics in the Longissimus dorsi of Hanwoo steers (Korean native cattle). Anim Sci J 88(6):847–853. https://doi.org/10.1111/asj.12660
List GR (2015) Soybean lecithin: food, industrial uses, and other applications. In: Ahmad MU, Xu X (eds) Polar lipids. Elsevier, Amsterdam, pp 1–33
Liu Y, Tian Y, Cai W, Guo Y, Xue C, Wang J (2021) DHA/EPA-Enriched phosphatidylcholine suppresses tumor growth and metastasis via activating peroxisome proliferator-activated receptor γ in lewis lung cancer mice. J Agric Food Chem 69(2):676–685. https://doi.org/10.1021/acs.jafc.0c06890
Lombardi B, Pani P, Schlunk FF (1968) Choline-deficiency fatty liver: impaired release of hepatic triglycerides. J Lipid Res 9(4):437–446. https://doi.org/10.1016/S0022-2275(20)42721-X
Lu C, Wang Y, Wang D, Zhang L, Lv J, Jiang N, Fan B, Liu X, Wang F (2018) Neuroprotective effects of soy isoflavones on scopolamine-induced amnesia in mice. Nutrients 10(7):853. https://doi.org/10.3390/nu10070853
Magil SG, Zeisel SH, Wurtman RJ (1981) Effects of ingesting soy or egg lecithins on serum choline, brain choline and brain acetylcholine. J Nutr 111(1):166–170. https://doi.org/10.1093/jn/111.1.166
Mangrulkar S, Shah P, Navnage S, Mazumdar P, Chaple D (2021) Phytophospholipid complex of caffeic acid: development, in vitro characterization, and in vivo investigation of antihyperlipidemic and hepatoprotective action in rats. AAPS PharmSciTech 22(1):28. https://doi.org/10.1208/s12249-020-01887-7
McClements DJ (2011) Edible nanoemulsions: fabrication, properties, and functional performance. Soft Matter 2011(7):2297–2316
Miclotte L, De Paepe K, Rymenans L, Callewaert C, Raes J, Rajkovic A, Van Camp J, Van de Wiele T (2020) Dietary emulsifiers alter composition and activity of the human gut microbiota in vitro, irrespective of chemical or natural emulsifier origin. Front Microbiol. https://doi.org/10.3389/fmicb.2020.577474
Moré MI, Freitas U, Rutenberg D (2014) Positive effects of soy lecithin-derived phosphatidylserine plus phosphatidic acid on memory, cognition, daily functioning, and mood in elderly patients with Alzheimer’s disease and dementia. Adv Ther 31:1247–1262
Mourad AM, de Carvalho Pincinato E, Mazzola PG, Sabha M, Moriel P (2010) Influence of soy lecithin administration on hypercholesterolemia. Cholesterol 2010:1–4. https://doi.org/10.1155/2010/824813
Müller CP, Reichel M, Mühle C, Rhein C, Gulbins E, Kornhuber J (2015) Brain membrane lipids in major depression and anxiety disorders. Biochim Et Biophys Acta (BBA) Mol Cell Biol Lipids 1851:1052–1065. https://doi.org/10.1016/j.bbalip.2014.12.014
Naimi S, Viennois E, Gewirtz AT, Chassaing B (2021) Direct impact of commonly used dietary emulsifiers on human gut microbiota. Microbiome 9(1):66. https://doi.org/10.1186/s40168-020-00996-6
Nemati M, Ghasemi HA, Hajkhodadadi I, Moradi MH (2021) De-oiled soy lecithin positively influenced growth performance, nutrient digestibility, histological intestinal alteration, and antioxidant status in turkeys fed with low energy diets. Br Poult Sci 62(6):858–867. https://doi.org/10.1080/00071668.2021.1943312
Nguyen MT, Van de Walle D, Petit C, Beheydt B, Depypere F, Dewettinck K (2014) Map** the chemical variability of vegetable lecithins. J Am Oil Chem Soc 91(7):1093–1101. https://doi.org/10.1007/s11746-014-2455-9
Omoni AO, Aluko RE (2005) Soybean foods and their benefits: potential mechanisms of action. Nutr Rev 63(8):272–283. https://doi.org/10.1111/j.1753-4887.2005.tb00141.x
Ossoli A, Simonelli S, Vitali C, Franceschini G, Calabresi L (2016) Role of LCAT in atherosclerosis. J Atheroscler Thromb 23(2):119–127. https://doi.org/10.5551/jat.32854
Raj PV, Nitesh K, Prateek J, Sankhe MN, Rao JV, Rao CM, Udupa N (2011) Effect of lecithin on d-galactosamine induced hepatotoxicity through mitochondrial pathway involving Bcl-2 and Bax. Indian J Clin Biochem 26(4):378–384. https://doi.org/10.1007/s12291-011-0155-x
Rao R, Squillante IE, Kim KH (2007) Lipid-based cochleates: a promising formulation platform for oral and parenteral delivery of therapeutic agents. Crit Rev Ther Drug Carrier Syst 24(1):41–62. https://doi.org/10.1615/CritRevTherDrugCarrierSyst.v24.i1.20
Raut S, Bhadoriya SS, Uplanchiwar V, Mishra V, Gahane A, Jain SK (2012) Lecithin organogel: a unique micellar system for the delivery of bioactive agents in the treatment of skin aging. Acta Pharmaceutica Sinica B 2(1):8–15. https://doi.org/10.1016/j.apsb.2011.12.005
Riekkinen P (1975) Interaction between dopamine and phospholipids. Arch Neurol 32(1):25. https://doi.org/10.1001/archneur.1975.00490430047006
Richter Y, Herzog Y, Lifshitz Y, Hayun R, Zchut S (2013) The effect of soybean-derived phosphatidylserine on cognitive performance in elderly with subjective memory complaints: a pilot study. Clin Interv Aging 557–563
Rittiner J, Cumaran M, Malhotra S, Kantor B (2022) Therapeutic modulation of gene expression in the disease state: treatment strategies and approaches for the development of next-generation of the epigenetic drugs. Front Bioeng Biotechnol. https://doi.org/10.3389/fbioe.2022.1035543
Rondanelli M, Opizzi A, Solerte SB, Trotti R, Klersy C, Cazzola R (2008) Administration of a dietary supplement (N-oleyl-phosphatidylethanolamine and epigallocatechin-3-gallate formula) enhances compliance with diet in healthy overweight subjects: a randomized controlled trial. Br J Nutr 101(3):457–464
Ross R (1999) Atherosclerosis — an inflammatory disease. N Engl J Med 340(2):115–126. https://doi.org/10.1056/NEJM199901143400207
Rupp C, Steckel H, Müller BW (2010) Solubilization of poorly water-soluble drugs by mixed micelles based on hydrogenated phosphatidylcholine. Int J Pharm 395(1–2):272–280. https://doi.org/10.1016/j.ijpharm.2010.05.025
Salehi B, Quispe C, Sharifi-Rad J, Cruz-Martins N, Nigam M, Mishra AP, Konovalov DA, Orobinskaya V, Abu-Reidah IM, Zam W, Sharopov F, Venneri T, Capasso R, Kukula-Koch W, Wawruszak A, Koch W (2021) Phytosterols: from preclinical evidence to potential clinical applications. Front Pharmacol. https://doi.org/10.3389/fphar.2020.599959
Samanta K, Setua S, Kumari S, Jaggi M, Yallapu MM, Chauhan SC (2019) Gemcitabine combination nano therapies for pancreatic cancer. Pharmaceutics 11(11):574. https://doi.org/10.3390/pharmaceutics11110574
Schneider M, Levant B, Reichel M, Gulbins E, Kornhuber J, Müller CP (2017) Lipids in psychiatric disorders and preventive medicine. Neurosci Biobehav Rev 76:336–362. https://doi.org/10.1016/j.neubiorev.2016.06.002
Scholfield CR (1981) Composition of soybean lecithin. Journal of the American Oil Chemists’ Society 58(10):889–892. https://doi.org/10.1007/BF02659652
Semalty A, Semalty M, Rawat BS, Singh D, Rawat M (2009) Pharmacosomes: the lipid-based new drug delivery system. Expert Opin Drug Deliv 6(6):599–612. https://doi.org/10.1517/17425240902967607
Sherriff JL, O’Sullivan TA, Properzi C, Oddo J-L, Adams LA (2016) Choline, its potential role in nonalcoholic fatty liver disease, and the case for human and bacterial genes. Adv Nutr 7(1):5–13. https://doi.org/10.3945/an.114.007955
Singh A, Vengurlekar P, Rathod S (2014) Design, development and characterization of liposomal neem gel. Int J Pharma Sci Res (IJPSR) 5:140–148
Smit JJM, Schinkel AH, Elferink RPJO, Groen AK, Wagenaar E, van Deemter L, Mol CAAM, Ottenhoff R, van der Lugt NMT, van Roon MA, van der Valk MA, Offerhaus GJA, Berns AJM, Borst P (1993) Homozygous disruption of the murine MDR2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease. Cell 75(3):451–462. https://doi.org/10.1016/0092-8674(93)90380-9
Song Z, Deaciuc I, Zhou Z, Song M, Chen T, Hill D, McClain CJ (2007) Involvement of AMP-activated protein kinase in beneficial effects of betaine on high-sucrose diet-induced hepatic steatosis. Am J Physiol-Gastrointest Liver Physiol 293(4):G894–G902. https://doi.org/10.1152/ajpgi.00133.2007
Su C-Y, Liu J-J, Ho Y-S, Huang Y-Y, Chang VH-S, Liu D-Z, Chen L-C, Ho H-O, Sheu M-T (2018) Development and characterization of docetaxel-loaded lecithin-stabilized micellar drug delivery system (L sb MDDs) for improving the therapeutic efficacy and reducing systemic toxicity. Eur J Pharm Biopharm 123:9–19. https://doi.org/10.1016/j.ejpb.2017.11.006
Suzuki S, Yamatoya H, Sakai M, Kataoka A, Furushiro M, Kudo S (2001) Oral administration of soybean lecithin transphosphatidylated phosphatidylserine improves memory impairment in aged rats. J Nutr 131(11):2951–2956
Tabaniag JSU, Abad MQD, Morcelos CJR, Geraldino GVB, Alvarado JLM, Lopez ECR (2023) Stabilization of oil/water emulsions using soybean lecithin as a biobased surfactant for enhanced oil recovery. J Eng Appl Sci 70(1):154. https://doi.org/10.1186/s44147-023-00322-5
Tai K, Liu F, He X, Ma P, Mao L, Gao Y, Yuan F (2018) The effect of sterol derivatives on properties of soybean and egg yolk lecithin liposomes: stability, structure and membrane characteristics. Food Res Int 109:24–34
Taku K, Lin N, Cai D, Hu J, Zhao X, Zhang Y, Wang P, Melby MK, Hooper L, Kurzer MS, Mizuno S, Ishimi Y, Watanabe S (2010) Effects of soy isoflavone extract supplements on blood pressure in adult humans: systematic review and meta-analysis of randomized placebo-controlled trials. J Hypertens 28(10):1971–1982. https://doi.org/10.1097/HJH.0b013e32833c6edb
Tan A, Rao S, Prestidge CA (2013) Transforming lipid-based oral drug delivery systems into solid dosage forms: an overview of solid carriers, physicochemical properties, and biopharmaceutical performance. Pharm Res 30(12):2993–3017. https://doi.org/10.1007/s11095-013-1107-3
Tanaka-Kanegae R, Kimura H, Hamada K (2023) Oral administration of egg- and soy-derived lysophosphatidylcholine mitigated acetylcholine depletion in the brain of scopolamine-treated rats. Nutrients 15(16):3618. https://doi.org/10.3390/nu15163618
Thornton MH, Johnson CS, Ewan MA (1944) The component fatty acids of soybean lecithin. Oil & Soap 21(3):85–87. https://doi.org/10.1007/BF02568014
Toouli J, Jablonski P, Watts JM (1975) Dissolution of human gallstones: the efficacy of bile salt, bile salt plus lecithin and heparin solutions. J Surg Res 19(1):47–53. https://doi.org/10.1016/0022-4804(75)90039-6
van Hoogevest P, Wendel A (2014) The use of natural and synthetic phospholipids as pharmaceutical excipients. Eur J Lipid Sci Technol 116(9):1088–1107. https://doi.org/10.1002/ejlt.201400219
Wang L, Yin Q, Liu C, Tang Y, Sun C, Zhuang J (2021) Nanoformulations of ursolic acid: a modern natural anticancer molecule. Front Pharmacol. https://doi.org/10.3389/fphar.2021.706121
Wang J, He Z, Raghavan V (2023) Soybean allergy: characteristics, mechanisms, detection and its reduction through novel food processing techniques. Crit Rev Food Sci Nutr 63(23):6182–6195. https://doi.org/10.1080/10408398.2022.2029345
Wilson DR (2017). Everything you need to know about lecithin.
Wretlind A (1981) Invited review: development of fat emulsions. J Parenter Enter Nutr 5(3):230–235. https://doi.org/10.1177/0148607181005003230
**a X, Wang Y, Qin Y, Zhao S, Zheng JC (2022) Exosome: a novel neurotransmission modulator or non-canonical neurotransmitter? Ageing Res Rev 74:101558. https://doi.org/10.1016/j.arr.2021.101558
Zhang W, Chen Y, Wang W, Lan D, Wang Y (2023) Soy lecithin increases the stability and lipolysis of encapsulated algal oil and probiotics complex coacervates. J Sci Food Agric 103(8):4164–4173. https://doi.org/10.1002/jsfa.12422
Zhao F, Li R, Liu Y, Chen H (2023) Perspectives on lecithin from egg yolk: extraction, physicochemical properties, modification, and applications. Front Nutr. https://doi.org/10.3389/fnut.2022.1082671
Zhuang X, Clark S, Acevedo N (2021) Bigels—oleocolloid matrices—as probiotic protective systems in yogurt. J Food Sci 86(11):4892–4900. https://doi.org/10.1111/1750-3841.15928
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Shubhada V. Mangrulkar has no conflict of interest. Sayli S. Kulkarni has no conflict of interest. Pratiksha V. Nanepag has no conflict of interest. Pankaj S. Neje has no conflict of interest. D. R. Chaple has no conflict of interest. Brijesh G. Taksande has no conflict of interest. Milind J. Umekar has no conflict of interest.
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Mangrulkar, S.V., Kulkarni, S.S., Nanepag, P.V. et al. A comprehensive review on pleiotropic effects and therapeutic potential of soy lecithin. ADV TRADIT MED (ADTM) (2024). https://doi.org/10.1007/s13596-024-00770-1
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DOI: https://doi.org/10.1007/s13596-024-00770-1