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  1. Template-independent enzymatic synthesis of RNA oligonucleotides

    RNA oligonucleotides have emerged as a powerful therapeutic modality to treat disease, yet current manufacturing methods may not be able to deliver...

    Daniel J. Wiegand, Jonathan Rittichier, ... George M. Church in Nature Biotechnology
    Article Open access 12 July 2024

  3. Deep 3D histology powered by tissue clearing, omics and AI

    To comprehensively understand tissue and organism physiology and pathophysiology, it is essential to create complete three-dimensional (3D) cellular...

    Ali Ertürk in Nature Methods
    Article 12 July 2024

  6. Development of a low-cost system for the measurement of dynamic equilibrium in humans

    Introduction

    The maintenance of balance and body orientation during stance is essential for performing different activities. The aim of this study was...

    Marcelo Guimarães Silva, Marcelo Sampaio Martins, ... José Elias Tomazini in Research on Biomedical Engineering
    Article 11 July 2024

  9. Modified mesenchymal stromal cells by in vitro transcribed mRNA: a therapeutic strategy for hepatocellular carcinoma

    Background

    Mesenchymal stromal cells (MSCs) tropism for tumours allows their use as carriers of antitumoural factors and in vitro transcribed mRNA...

    María José Cantero, Barbara Bueloni, ... Mariana G. García in Stem Cell Research & Therapy
    Article Open access 11 July 2024

  10. Examining temporal changes in model-optimized parameters using longitudinal hemodynamic measurements

    Background

    We previously applied hemodynamic data to personalize a mathematical model of the circulation expressed as physically interpretable...

    Nikolai L. Bjørdalsbakke, Jacob Sturdy, ... Leif R. Hellevik in BioMedical Engineering OnLine
    Article Open access 10 July 2024

  11. Automatic localization of cochlear implant electrodes using cone beam computed tomography images

    Background

    Cochlear implants (CI) are implantable medical devices that enable the perception of sounds and the understanding of speech by electrically...

    Jasmin Thormählen, Benjamin Krüger, Waldo Nogueira in BioMedical Engineering OnLine
    Article Open access 10 July 2024

  12. Systematic optimization of prime editing for the efficient functional correction of CFTR F508del in human airway epithelial cells

    Prime editing (PE) enables precise and versatile genome editing without requiring double-stranded DNA breaks. Here we describe the systematic...

    Alexander A. Sousa, Colin Hemez, ... David R. Liu in Nature Biomedical Engineering
    Article Open access 10 July 2024

  14. Autotaxin Inhibition Reduces Post‐Ischemic Myocardial Inflammation via Epigenetic Gene Modifications

    Myocardial infarction (MI) triggers a complex inflammatory response that is essential for cardiac repair but can also lead to adverse outcomes if...

    Landys Z. Guo, Himi Tripathi, ... Ahmed Abdel-Latif in Stem Cell Reviews and Reports
    Article 10 July 2024

  15. CAR-Ts sweep into autoimmunity

    Charlotte Harrison in Nature Biotechnology
    Article 10 July 2024

  16. On the Importance of Including Cohesive Zone Models in Modelling Mixed-Mode Aneurysm Rupture

    Introduction

    The precise mechanism of rupture in abdominal aortic aneurysms (AAAs) has not yet been uncovered. The phenomenological failure criterion...

    J. Concannon, E. Ó. Máirtín, ... J. P. McGarry in Cardiovascular Engineering and Technology
    Article Open access 10 July 2024

  17. Localization of protoporphyrin IX during glioma-resection surgery via paired stimulated Raman histology and fluorescence microscopy

    The most widely used fluorophore in glioma-resection surgery, 5-aminolevulinic acid (5-ALA), is thought to cause the selective accumulation of...

    Mustafa Nasir-Moin, Lisa Irina Wadiura, ... Daniel A. Orringer in Nature Biomedical Engineering
    Article 10 July 2024

  18. Dynamic Transcriptional Programs During Single NK Cell Killing: Connecting Form to Function in Cellular Immunotherapy

    Introduction

    Natural killer (NK) cell-based therapies are a promising new method for treating indolent cancer, however engineering new therapies is...

    Joseph T. Decker, Matthew S. Hall, ... Lonnie D. Shea in Cellular and Molecular Bioengineering
    Article 09 July 2024

  19. A Modified Genetic Algorithm for Combined Heat and Power Economic Dispatch

    Combined Heat and Power Economic Dispatch (CHPED) is an important problem in the energy field, and it is beneficial for improving the utilization...

    Deliang Li, Chunyu Yang in Journal of Bionic Engineering
    Article 09 July 2024

  20. Correction to: The Influence of Phosphate Ion Concentrations on the Properties of Wollastonite-Apatite-Based Cements

    Vanessa Modelski Schatkoski, Thaís Larissa do Amaral Montanheiro, ... Gilmar Patrocínio Thim in Biomedical Materials & Devices
    Article 09 July 2024
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