Fluorescence guidance is utilized to increase the chances of complete tumour resection while balancing preservation of neurological function in glioma surgery. A multimodal optical microscope capable of imaging the histology and fluorescence of fresh human brain specimens revealed an unexpected pattern of fluorophore accumulation and a new means of visualizing macrophages during surgery.
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This is a summary of: Nasir-Moin, M. et al. Localization of protoporphyrin IX during glioma-resection surgery via paired stimulated Raman histology and fluorescence microscopy. Nat. Biomed. Eng. https://doi.org/10.1038/s41551-024-01217-3 (2024).
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Optical microscopy and transcriptomics reveal the origins of fluorescence in glioma surgery. Nat. Biomed. Eng (2024). https://doi.org/10.1038/s41551-024-01218-2
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DOI: https://doi.org/10.1038/s41551-024-01218-2
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