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Biochemistry, general

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  1. Domino Dendrimers

    Domino dendrimers have recently been developed and introduced as a potential platform for a single triggered multi-prodrug. Surprisingly, three...
    Roey J. Amir, Doron Shabat in Polymer Therapeutics I
    Chapter

  2. Molecular-Scale Studies on Biopolymers Using Atomic Force Microscopy

    The atomic force microscope (AFM) is capable of acquiring a range of structural and physicochemical information on a wide range of biopolymers. The...
    James S. Ellis, Stephanie Allen, ... Martyn C. Davies in Polymer Therapeutics II
    Chapter

  3. Polymer Genomics

    Biological activities of biocompatible synthetic polymers used in drug delivery, gene delivery, vaccine development or biomaterial surface...
    Alexander V. Kabanov, Elena V. Batrakova, ... Valery Y. Alakhov in Polymer Therapeutics II
    Chapter

  4. Solid-State Structure, Organizationand Properties of Peptide—Synthetic Hybrid Block Copolymers

    Peptide–synthetic hybrid block copolymers are most easily prepared via ring-opening polymerization of α-amino acid N-carboxyanhydrides using...
    Harm-Anton Klok, Sébastien Lecommandoux in Peptide Hybrid Polymers
    Chapter

  5. In Vitro Enzyme-Induced Vinyl Polymerization

    The in vitro enzyme-mediated polymerization of vinyl monomers is reviewed with a scope covering enzymatic polymerization of vitamin C...
    Amarjit Singh, David L. Kaplan in Enzyme-Catalyzed Synthesis of Polymers
    Chapter

  6. Enzymatic Synthesis of Polyesters via Polycondensation

    In vitro synthesis of polyesters by polycondensation using isolated enzymes as catalyst via nonbiosynthetic pathways is reviewed. In most cases,...
    Hiroshi Uyama, Shiro Kobayashi in Enzyme-Catalyzed Synthesis of Polymers
    Chapter

  7. Enzymatic Catalysis in the Synthesis of Polyanilines and Derivatives of Polyanilines

    Enzyme catalysis in the synthesis of polyaniline is reviewed. Oxidoreductase enzymes and biomimetic catalysts have been used for the polymerization...
    Peng Xu, Amarjit Singh, David L. Kaplan in Enzyme-Catalyzed Synthesis of Polymers
    Chapter

  8. Synthesis of Bio-Inspired Hybrid PolymersUsing Peptide Synthesis and Protein Engineering

    The construction of well-defined hybrid materials consisting of synthetic polymers and (poly)peptides or proteins has attracted much attention in...
    Dennis W. P. M. Löwik, Lee Ayres, ... Jan C. M. Van Hest in Peptide Hybrid Polymers
    Chapter

  9. Preparation and Electron Conductivity of DNA-Aligned Cast and LB Films from DNA-Lipid Complexes

    We describe here a simple preparation of a DNA-lipid complex that is soluble in organic media, and preparations of DNA-aligned thin films from the...
    Yoshio Okahata, Takayoshi Kawasaki in Immobilisation of DNA on Chips I
    Chapter

  10. Detection of Mutations in Rifampin-Resistant Mycobacterium Tuberculosis by Short Oligonucleotide Ligation Assay on DNA Chips (SOLAC)

    A new approach, a short oligonucleotide ligation assay on DNA chips (SOLAC) is developed to detect DNA mutations. The SOLAC approach can be carried...
    **an-En Zhang, Jiao-Yu Deng in Immobilisation of DNA on Chips II
    Chapter

  11. Production and Formulation of Adenovirus Vectors

    Adenovirus vectors have attracted considerable interest over the past decade, with ongoing clinical development programs for applications ranging...
    Nedim E. Altaras, John G. Aunins, ... Jayanthi J. Wolf in Gene Therapy and Gene Delivery Systems
    Chapter

  12. Nonviral Delivery of Cancer Genetic Vaccines

    The potential use of genetic vaccines to address numerous diseases including cancer is promising, but currently unrealized. Here, we review...
    Steven R. Little, Robert Langer in Gene Therapy and Gene Delivery Systems
    Chapter

  13. Advanced Targeting Strategies for Murine Retroviral and Adeno-associated Viral Vectors

    Targeted gene delivery involves broadening viral tropism to infect previously nonpermissive cells, replacing viral tropism to infect a target cell...
    Julie H. Yu, David V. Schaffer in Gene Therapy and Gene Delivery Systems
    Chapter

  14. Molecular Conjugates

    Molecular conjugates are nanometer-sized entities consisting of synthetic materials (lipids, polycations, targeting agents, and so on) and nucleic...
    Jeremy Heidel, Swaroop Mishra, Mark E. Davis in Gene Therapy and Gene Delivery Systems
    Chapter

  15. Cyclodextrin-Based Supramolecular Polymers

    Supramolecular polymers were prepared by inclusion of a guest in cyclodextrin via a covalent bond. The structures of the supramolecular oligomers and...
    Akira Harada, Akihito Hashidzume, Yoshinori Takashima in Supramolecular Polymers Polymeric Betains Oligomers
    Chapter

  16. Introduction: Lipids: cellular glue...or are they more than that?

    Some 40 years ago, there was a rumor in the research community that lipids are the stuff you have to throw away before starting biochemical...
    Günther Daum in Lipid Metabolism and Membrane Biogenesis
    Chapter

  17. 10 Sphingosine-1-phosphate metabolism in mammalian cell signalling

    Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid metabolite implicated in the regulation of vital biological processes. Ample evidence...
    Hervé Le Stunff, Sylvie Coursol, ... Sarah Spiegel in Lipid Metabolism and Membrane Biogenesis
    Chapter

  18. Role of NAADP in Coordinating Spatiotemporal Aspects of Calcium Signalling

    We outline the roles of two low molecular weight phosphorylated compounds as intracellular messengers in calcium signaling. These new intracellular...
    Grant C. Churchill, Antony Galione in Understanding Calcium Dynamics
    Chapter

  19. 8 Biosynthesis and compartmentation of triacylglycerol in higher plants

    The biosynthesis of storage lipids (triacylglycerols) in higher plants is now known to occur via a number of different routes. These include the...
    Frédéric Beaudoin, Johnathan A. Napier in Lipid Metabolism and Membrane Biogenesis
    Chapter

  20. Building a Wave – Models of the Puff-to-Wave Transition

    Ca2+ release channels open and close randomly because of random binding and dissociation of Ca2+ and IP3 to their subunits. They are arranged in...
    Martin Falcke in Understanding Calcium Dynamics
    Chapter
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