Abstract
The in vitro enzyme-mediated polymerization of vinyl monomers is reviewed with a scope covering enzymatic polymerization of vitamin C functionalized vinyl monomers, styrene, derivatives of styrene, acrylates, and acrylamide in water and water-miscible cosolvents. Vitamin C functionalized polymers were synthesized via a two-step biocatalytic approach where vitamin C was first regioselectively coupled to vinyl monomers and then subsequently polymerized. The analysis of this enzymatic cascade approach to functionalized vinyl polymers showed that the vitamin C in polymeric form retained its antioxidant property. Kinetic and mechanistic studies revealed that a ternary system (horseradish peroxidase, H2O2, initiator β-diketone) was required for efficient polymerization and that the initiator controls the characteristics of the polymer. The main attributes of enzymatic approaches to vinyl polymerization when compared with more traditional synthetic approaches include facile ambient reaction environments of temperature and pressure, aqueous conditions, and direct control of selectivity to generate functionalized materials as described for the ascorbic acid modified polymers.
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Singh, A., Kaplan, D.L. In Vitro Enzyme-Induced Vinyl Polymerization. In: Kobayashi, S., Ritter, H., Kaplan, D. (eds) Enzyme-Catalyzed Synthesis of Polymers. Advances in Polymer Science, vol 194. Springer, Berlin, Heidelberg. https://doi.org/10.1007/12_033
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DOI: https://doi.org/10.1007/12_033
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