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Pressure sensing of lysosomes enables control of TFEB responses in macrophages
Polymers are endocytosed and hydrolysed by lysosomal enzymes to generate transportable solutes. While the transport of diverse organic solutes across...
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Full-length GSDME mediates pyroptosis independent from cleavage
Gasdermin (GSDM) family proteins, known as the executors of pyroptosis, undergo protease-mediated cleavage before inducing pyroptosis. We here...
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Neutrophil-derived migrasomes are an essential part of the coagulation system
Migrasomes are organelles that are generated by migrating cells. Here we report the key role of neutrophil-derived migrasomes in haemostasis. We...
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PTBP1 protects Y RNA from cleavage leading to its apoptosis-specific degradation
Some RNAs such as 28S rRNA, U1 small nuclear RNA (snRNA), and Y RNAs are known to be cleaved during apoptosis. The underlying mechanism, functions,...
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Recent advances in nanomaterials for the treatment of femoral head necrosis
Osteonecrosis of the femoral head (ONFH) is a condition that causes considerable pain and discomfort for patients, and its pathogenic mechanisms are...
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Comparative analysis of reduced toxicity conditioning regimens between fludarabine plus melphalan and fludarabine plus busulfex in adult patients with acute lymphoblastic leukemia
Reduced-toxicity conditioning (RTC) regimens aim to mitigate regimen-related toxicity while maintaining anti-leukemic efficacy in allogeneic...
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Polycomb function in early mouse development
Epigenetic factors are crucial for ensuring proper chromatin dynamics during the initial stages of embryo development. Among these factors, the...
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Vaginal irritation testing—prospects of human organotypic vaginal tissue culture models
Personal lubricants intended for local or systemic delivery via the vaginal route can induce vaginal irritation, damage the vaginal epithelial...
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YTH domain family protein 3 accelerates non-small cell lung cancer immune evasion through targeting CD8+ T lymphocytes
Immune evasion is one of the critical hallmarks of malignant tumors, especially non-small cell lung cancer (NSCLC). Emerging findings have...
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Exploring the osteogenic potential of semisynthetic triterpenes from Combretum leprosum: An in vitro and in silico study
Combretum leprosum Mart. is a plant of the Combretaceae family, widely distributed in the Northeast region of Brazil, popularly used as an...
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Dexmedetomidine and argon in combination against ferroptosis through tackling TXNIP-mediated oxidative stress in DCD porcine livers
Graft availability from donation after circulatory death (DCD) is significantly limited by ischaemia reperfusion (IR) injury. Effective strategies to...
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RNA scaffolds the Golgi ribbon by forming condensates with GM130
The mammalian Golgi is composed of stacks that are laterally connected into a continuous ribbon-like structure. The integrity and function of the...
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Noneffectiveness of cryostorage duration on clinical and neonatal outcomes after single vitrified-warmed blastocyst transfers
BackgroundIn the current era of assisted reproductive technology, the strategy of single vitrified-warmed blastocyst transfer (SVBT) is acknowledged...
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Synthetic macrolides overcoming MLSBK-resistant pathogens
Conventional macrolide-lincosamide-streptogramin B-ketolide (MLS B K) antibiotics are unable to counter the growing challenge of antibiotic resistance...
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Advancing stroke recovery: unlocking the potential of cellular dynamics in stroke recovery
Stroke stands as a predominant cause of mortality and morbidity worldwide, and there is a pressing need for effective therapies to improve outcomes...
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Modified mesenchymal stromal cells by in vitro transcribed mRNA: a therapeutic strategy for hepatocellular carcinoma
BackgroundMesenchymal stromal cells (MSCs) tropism for tumours allows their use as carriers of antitumoural factors and in vitro transcribed mRNA...
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Dysregulated Wnt/β-catenin signaling confers resistance to cuproptosis in cancer cells
Cuproptosis is characterized by the aggregation of lipoylated enzymes of the tricarboxylic acid cycle and subsequent loss of iron-sulfur cluster...
