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Drug screening on digital microfluidics for cancer precision medicine
Drug screening based on in-vitro primary tumor cell culture has demonstrated potential in personalized cancer diagnosis. However, the limited number...
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Drug cytotoxicity screening using human intestinal organoids propagated with extensive cost-reduction strategies
Organoids are regarded as physiologically relevant cell models and useful for compound screening for drug development; however, their applications...
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First fully-automated AI/ML virtual screening cascade implemented at a drug discovery centre in Africa
Streamlined data-driven drug discovery remains challenging, especially in resource-limited settings. We present ZairaChem, an artificial intelligence...
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Drug screening at single-organoid resolution via bioprinting and interferometry
High throughput drug screening is an established approach to investigate tumor biology and identify therapeutic leads. Traditional platforms use...
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PeruNPDB: the Peruvian Natural Products Database for in silico drug screening
Since the number of drugs based on natural products (NPs) represents a large source of novel pharmacological entities, NPs have acquired significance...
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A semiconductor 96-microplate platform for electrical-imaging based high-throughput phenotypic screening
High-content imaging for compound and genetic profiling is popular for drug discovery but limited to endpoint images of fixed cells. Conversely,...
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Computational approaches streamlining drug discovery
Computer-aided drug discovery has been around for decades, although the past few years have seen a tectonic shift towards embracing computational...
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Microfluidic-assisted synthesis and modeling of stimuli-responsive monodispersed chitosan microgels for drug delivery applications
Droplet microfluidic has been established to synthesize and functionalize micro/nanoparticles for drug delivery and screening, biosensing,...
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CRISPR-dCas13d-based deep screening of proximal and distal splicing-regulatory elements
Pre-mRNA splicing, a key process in gene expression, can be therapeutically modulated using various drug modalities, including antisense...
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Deep representation learning of chemical-induced transcriptional profile for phenotype-based drug discovery
Artificial intelligence transforms drug discovery, with phenotype-based approaches emerging as a promising alternative to target-based methods,...
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The Pan-Canadian Chemical Library: A Mechanism to Open Academic Chemistry to High-Throughput Virtual Screening
Computationally screening chemical libraries to discover molecules with desired properties is a common technique used in early-stage drug discovery....
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Heteroatom-doped carbon dots from medicinal plants as novel biomaterials for as-use biomedical applications in comparison with synthetic drug, zaltoprofen
FN-doped carbon dots were synthesized using powdered leaves of Moringa oleifera L./ Chromolaena odorata L./ Tridax procumbens L./ Tinospora cordifolia ...
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Dynamic microfluidic single-cell screening identifies pheno-tuning compounds to potentiate tuberculosis therapy
Drug-recalcitrant infections are a leading global-health concern. Bacterial cells benefit from phenotypic variation, which can suggest effective...
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Phenotypic screening of signaling motifs that efficiently induce cell proliferation
Since cell proliferation is one of the fundamental cell fates, artificial control of cell proliferation based on a receptor-engineering approach is...
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A massively parallel screening platform for converting aptamers into molecular switches
Aptamer-based molecular switches that undergo a binding-induced conformational change have proven valuable for a wide range of applications, such as...
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Magnetically driven capsules with multimodal response and multifunctionality for biomedical applications
Untethered capsules hold clinical potential for the diagnosis and treatment of gastrointestinal diseases. Although considerable progress has been...
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Autocorrelation analysis of a phenotypic screen reveals hidden drug activity
Phenotype based screening is a powerful tool to evaluate cellular drug response. Through high content fluorescence imaging of simple fluorescent...
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Single-molecule fingerprinting of protein-drug interaction using a funneled biological nanopore
In drug discovery, efficient screening of protein-drug interactions (PDIs) is hampered by the limitations of current biophysical approaches. Here, we...
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Openable artificial intestinal tract device integrated with a permeable filter for evaluating drug permeation through cells
Organs-on-chips using cultured cells have been developed and applied for evaluating in vitro biological phenomena. We previously reported an openable...
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Streamlining pipeline efficiency: a novel model-agnostic technique for accelerating conditional generative and virtual screening pipelines
The discovery of potential therapeutic agents for life-threatening diseases has become a significant problem. There is a requirement for fast and...
