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Opioid-induced neuroanatomical, microglial and behavioral changes are blocked by suvorexant without diminishing opioid analgesia
Heroin use disorder in humans and chronic opioid administration to mice result in an increase in the number and a decrease in the size of detected...
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Mu Opioid Receptor Dynamics in Healthy Volunteers with a History of Childhood Maltreatment
Evidence suggests that adults with a history of childhood maltreatment, the experience of emotional or physical neglect and/or abuse within the...
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μ-opioid receptor availability is associated with sex drive in human males
The endogenous mu-opioid receptor (MOR) system modulates a multitude of social and reward-related functions, and exogenous opiates also influence sex...
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Multi-informant Implementation and Intervention Outcomes of Opioid Overdose Education and Naloxone Distribution in New York City
Overdose Education and Naloxone Distribution (OEND) is an effective public health intervention to reduce opioid overdose fatalities (McDonald and...
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Aberrant brain activity in pedophilia links to receptor distribution, gene expression, and behavior
Despite an estimated lifetime prevalence of 0.5–1.0% in men and high public concern, no effective treatment is known for pedophilic disorder. Here,...
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Bending and bonding: a randomized controlled trial on the socio-psychobiological effects of spiritual versus secular yoga practice on social bonding
Participating in rituals gives rise to exceptional social bonding, but how this happens is not well understood. We assess the roles of four potential...
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Multivariate genome-wide association meta-analysis of over 1 million subjects identifies loci underlying multiple substance use disorders
Genetic liability to substance use disorders can be parsed into loci that confer general or substance-specific addiction risk. We report a...
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Why This Book?
What motivated the author to write the book? American scientists want to solve the “opioid crisisOpioid crisis” in the US through a better...
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The role of the opioid system in decision making and cognitive control: A review
The opioid system regulates affective processing, including pain, pleasure, and reward. Restricting the role of this system to hedonic modulation may...
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Psychopharmacologic Treatment of Psychiatric Disorders in First Responders
First responders are vulnerable to the same psychiatric conditions and symptoms that affect the general population. However, they are particularly...
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Neuroendocrine Regulation of Anxiety
The reciprocal interaction between the central nervous system and endocrine signals plays a pivotal role in sha** emotional processing and...
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Newborn Neurobehavior and the Development of Infant Mental Health
Newborn neurobehavior enables us to identify individual differences and temperament, differential susceptibility and to identify at-risk-infants....
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Neurocircuitry basis of motor cortex-related analgesia as an emerging approach for chronic pain management
Aside from movement initiation and control, the primary motor cortex (M1) has been implicated in pain modulation mechanisms. A large body of clinical...
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Hypnotic Dependence and Withdrawal
The use of hypnotic drugs has always been an important topic given the enormous commercial success of these drugs since their launch and the...
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A Common Mechanism for Anxiety Disorders and Drug Addiction: Implications for Current and Novel Pharmacological Treatments
Anxiety treatment protocols in adolescents generally follow the same guidelines as treatment of anxiety in adults. In order to provide a working...
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Oxytocin
This chapter reviews the workings of oxytocin, nested in hypothalamic and pituitary (or hypophysis) brain structures, and fundamental for human...
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Response to the Opioid Epidemic: Current Treatment Models in the United States
Opioid use disorder (OUD) is a complex condition requiring a multifaceted treatment approach. As such, a variety of different models, both...
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The Transmitters
Synaptic transmission is both, an essential process in the functioning of our brain and the most important site for plastic changes, at least in the...