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Effect of processing method on platycodin D content in Platycodon grandiflorum roots
Platycodon grandiflorum root is a traditional medicine and food material rich in triterpenoid saponins. Its major constituent, platycodin D (PD), is...
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Advances in plant-derived natural products for antitumor immunotherapy
In recent years, immunotherapy has emerged as a novel antitumor strategy in addition to traditional surgery, radiotherapy and chemotherapy. It...
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Neurological disorders of COVID-19: insights to applications of natural products from plants and microorganisms
In addition to the typical respiratory manifestations, various disorders including involvement of the nerve system have been detected in COVID-19...
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pH-dependent release of platycodin mitigates its gastrointestinal mucosa irritation after oral administration in rats
The present study aimed to evaluate the gastrointestinal mucosa irritation of three platycodin formulations. Platycodin-loaded core pellets were...
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The effect of statins and the synthetic LXR agonist T0901317 on expression of ABCA1 transporter protein in human lung epithelial cell lines in vitro
BackgroundThe pathogenesis of chronic obstructive pulmonary disease (COPD) is associated with dyslipidemia, an established co-morbidity. Statins...
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Platycodi radix saponin inhibits α-glucosidase in vitro and modulates hepatic glucose-regulating enzyme activities in C57BL/KsJ-db/db mice
This study investigated anti-diabetic activity of a concentrated saponin fraction from Platycodi radix (SK1) in C57BL/KsJ- db/db mice and its...
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Newest Results on the Chemistry and Pharmacology of TCM Drugs Containing Triterpene and Steroid Saponins
The aim of this review is to provide newest results in the chemistry, pharmacology, and clinical studies of saponins-containing TCM drugs, some of...
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Protective effect of stress-induced liver damage by saponin fraction from Codonopsis lanceolata
Saponins are valuable principles found in various herbal medicine with pharmaceutical, cosmetical and nutraceutical merits. In this study, we...
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Inhibitory effect of saponin fraction from Codonopsis lanceolata on immune cell-mediated inflammatory responses
Saponin components are known to be pharmaceutically, cosmetically and nutraceutically valuable principles found in various herbal medicine. In this...
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A new pancreatic lipase inhibitor isolated from the roots of Actinidia arguta
A new coumaroyl triterpene, 3- O-trans-p -coumaroyl actinidic acid ( 1 ), as well as five known triterpenes, ursolic acid ( 2 ), 23-hydroxyursolic acid ( 3 ),...
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Chemopreventive effect of saponins derived from roots ofPlatycodon grandiflorum on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis in A/J mice
This study examined the chemopreventive effect of saponins that were isolated from the roots of Platycodon grandiflorum A DC (Campanulaceae), Changkil...
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Determination of the kinetic properties of platycodin D for the inhibition of pancreatic lipase using a 1,2-diglyceride-based colorimetric assay
A 1, 2-diglyceride-based multi-step colorimetric assay to measure the pancreatic lipase activity was applied for the determination of the kinetic...
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In vitro inhibitory effect of triterpenoidal saponins from platycodi radix on pancreatic lipase
In the process of investigating anti-obesity effect of Platycodi Radix, we found that aqueous extract of Platycodi Radix might inhibit intestinal...
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Determination of the kinetic properties of platycodin D for the inhibition of pancreatic lipase using a 1, 2-diglyceride-based colorimetric assay
A 1, 2-diglyceride-based multi-step colorimetric assay to measure the pancreatic lipase activity was applied for the determination of the kinetic...
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