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Chemophenetic and Chemodiversity Approaches: New Insights on Modern Study of Plant Secondary Metabolite Diversity at Different Spatiotemporal and Organizational Scales
The study of plant secondary metabolites, now designated as specialized metabolites, is motivated by multiple scientific objectives, ranging from...
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Case studies for implementing MCDA for tender and purchasing decisions in hospitals in Indonesia and Thailand
BackgroundA multi-criteria decision analysis (MCDA) approach has been suggested for hel** purchasers in low- and middle-income countries in an...
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State of the European Union’s early notification obligation for drug shortages: enforcement and compliance in eight European countries (2020–2022)
BackgroundEarly notification of impending drug shortages is essential for mitigating or preventing shortages. Since 2019 pharmaceutical companies in...
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Inhibitors of Nitric Oxide Production from the Seeds of Myristica fragrans: Experimental and Computational Results
This study focuses on the extraction of eleven compounds from Myristica fragrans Houtt., Miristicaceae, seeds, guided by their anti-inflammatory...
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Antibacterial Activity and AbFtsZ Binding Properties of Fungal Metabolites Isolated from Mexican Mangroves
Antimicrobial resistance is emerging as a global health challenge that requires immediate and concerted attention. Accordingly, the WHO has issued...
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Bayesian Methods in Human Drug and Biological Products Development in CDER and CBER
The Center for Drug Evaluation and Research (CDER) and the Center for Biologics Evaluation and Research (CBER) of the U.S. Food and Drug...
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A Study Design for Augmenting the Control Group in a Randomized Controlled Trial: A Quality Process for Interaction Among Stakeholders
There is an increasing demand for utilization of external data, such as historical study data and patient registry data, to augment the control group...
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Design, Characterization and Optimization of Solid Lipid Nanoparticles of Bupropion by Using 23 Factorial Design
Nanotechnology is emerging as a field in medicine that is expected to elicit significant therapeutic benefits. The main objective of the present...
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Industry Assessment of the Contribution of Patient Support Programs, Market Research Programs, and Social Media to Patient Safety
BackgroundOver the past decade, the volume of adverse events (AEs) reported to marketing authorization holders and regulators has been rapidly...
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Incorporating Prior Data in Quantitative Benefit–Risk Assessments: Case Study of a Bayesian Method
BackgroundMultiple criteria decision analysis (MCDA) and stochastic multi-criteria acceptability analysis (SMAA) in their current implementation...
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The Effect of Phytocompounds of Medicinal Plants on Coronavirus (2019-NCOV) Infection
The recent outbreak of coronavirus disease 2019 (COVID-19) is a respiratory infection and it can spread from animal to person, person to person...
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Statistical Considerations on the Use of RWD/RWE for Oncology Drug Approvals: Overview and Lessons Learned
Despite increasing utilization of real-world data (RWD)/real-world evidence (RWE) in regulatory submissions, their application to oncology drug...
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Extended-Release Tablets of Nitrofurantoin: An Old Antibiotic Carried in a New Formulation
Nitrofurantoin is an old antibiotic currently prescribed to treat urinary tract infections. High dosing frequency causes fluctuations in the drug...
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Exploring new histone deacetylase 6 inhibitors and their effects on reversing the α-tubulin deacetylation and cell morphology changes caused by methamphetamine
Indazole-based HDAC6 inhibitors with novel zinc-binding modifications were synthesized and evaluated to determine their potential to inhibit HDAC6....
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Effects of phytoestrogens on reproductive organ health
Phytoestrogens are non-steroidal, polyphenolic compounds that are derived from plants and have biological properties similar to those of human...
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Antiviral peptides against SARS-CoV-2: therapeutic targets, mechanistic antiviral activity, and efficient delivery
The global pandemic of COVID-19 is a serious public health concern. Over 625 million confirmed cases and more than 6 million deaths have been...
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Allosteric modulation of dopamine D2L receptor in complex with Gi1 and Gi2 proteins: the effect of subtle structural and stereochemical ligand modifications
BackgroundAllosteric modulation of G protein-coupled receptors (GPCRs) is nowadays one of the hot topics in drug discovery. In particular, allosteric...
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Design, Synthesis and Biological Evaluation of Amide Derivatives of Thiazolo[5,4-d]Pyrimidines as Cytotoxicity Agents for Human Cancer Cell Lines
We have designed and synthesized a new series of amide derivatives of thiazolo[5,4- d ]pyrimidines ( 10a-j ) and their structures were characterized by 1 H...
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Low Molecular Weight NGF Mimetic Enhances the Overall Plasma Antioxidant Capacity in Rats with Streptozotocin-Induced Diabetes
Results from studies of the antidiabetic and antihyperglycemic activity of a low-molecular-weight NGF mimetic, compound GR-2 [bis-( N -monosuccinyl- L -glutamyl-...
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Quality analysis of manufacturer's incident reports regarding medical devices
BackgroundMedical devices provide a great number of medical treatments and have an important role in patients’ healthcare; however, there are certain...
