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Role of stanniocalcin-1 and proenkephalin-A as novel biomarkers in prediction of newly diagnosed type 2 diabetic patients
BackgroundDiabetes mellitus is a chronic metabolic disorder that carries substantial implications for health, social well-being, and economic...
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Proenkephalin as a biomarker correlates with acute kidney injury: a systematic review with meta-analysis and trial sequential analysis
BackgroundProenkephalin A 119-159 (PENK) is freely filtered in the glomerulus with plasma levels correlating with glomerular filtration rate....
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Plasma proenkephalin A and incident chronic kidney disease and albuminuria in the REasons for Geographic And Racial Differences in Stroke (REGARDS) cohort
BackgroundPlasma proenkephalin A (PENK-A) is a precursor of active enkephalins. Higher blood concentrations have been associated with estimated...
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Plasma proenkephalin and neutrophil gelatinase-associated lipocalin predict mortality in ICU patients with acute kidney injury
BackgroundAcute kidney injury (AKI) is a common complication in patients admitted to intensive care unit (ICU) and mortality rates for this condition...
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Proenkephalin A 119–159 predicts early and successful liberation from renal replacement therapy in critically ill patients with acute kidney injury: a post hoc analysis of the ELAIN trial
BackgroundRenal replacement therapy (RRT) remains the key rescue therapy for critically ill patients with severe acute kidney injury (AKI). However,...
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Cerebrospinal fluid levels of proenkephalin and prodynorphin are differentially altered in Huntington’s and Parkinson’s disease
BackgroundProenkephalin (PENK) and prodynorphin (PDYN) are peptides mainly produced by the striatal medium spiny projection neurons (MSNs) under...
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Plasma proenkephalin A 119–159 on intensive care unit admission is a predictor of organ failure and 30-day mortality
BackgroundProenkephalin A 119-159 (penKid) has been suggested as a marker of renal failure and poor outcome. We aimed to investigate the association...
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Evaluation of Proenkephalin A 119–159 for liberation from renal replacement therapy: an external, multicenter pilot study in critically ill patients with acute kidney injury
IntroductionRecent evidence suggests an association of plasma Proenkephalin A 119–159 (penKid) with early and successful liberation from continuous...
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Predictive value of plasma proenkephalin and neutrophil gelatinase-associated lipocalin in acute kidney injury and mortality in cardiogenic shock
BackgroundAcute kidney injury (AKI) is a frequent form of organ injury in cardiogenic shock. However, data on AKI markers such as plasma...
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Proenkephalin a 119–159 (penKid) – a novel biomarker for acute kidney injury in sepsis: an observational study
BackgroundSepsis is a leading cause of death worldwide and a major challenge for physicians to predict and manage. Proenkephalin A 119–159 (penKid)...
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Furosemide stress test to predict acute kidney injury progression in critically ill children
BackgroundFurosemide stress test (FST) is a novel functional biomarker for predicting severe acute kidney injury (AKI); however, pediatric studies...
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Moving toward a contemporary classification of drug-induced kidney disease
Drug-induced kidney disease (DIKD) accounts for about one-fourth of all cases of acute kidney injury (AKI) in hospitalized patients, especially in...
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Proenkephalin and prognosis in heart failure with preserved ejection fraction: a GREAT network study
BackgroundProenkephalin (PENK), a stable endogenous opioid biomarker related to renal function, has prognostic utility in acute and chronic heart...
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Subclinical and clinical acute kidney injury share similar urinary peptide signatures and prognosis
PurposeAcute kidney injury (AKI) is a frequent and severe condition in intensive care units (ICUs). In 2020, the Acute Dialysis Quality Initiative...
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Neueste Entwicklungen bei der akuten Nierenschädigung
Acute kidney injury (AKI) is a common problem in critically ill patients and is associated with increased morbidity and mortality. Since 2012, AKI...
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Biologic Therapy in Chronic Pain Management: a Review of the Clinical Data and Future Investigations
PurposeWith the aging population, it is clear that the demand for future chronic pain treatment modalities is at an all-time high. One of the newest...
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Biomarkers for prediction of acute kidney injury in pediatric patients: a systematic review and meta-analysis of diagnostic test accuracy studies
BackgroundSeverity of acute kidney injury (AKI) confers higher odds of mortality. Timely recognition and early initiation of preventive measures may...
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Use of lactulose as a prebiotic in laying hens: its effect on growth, egg production, egg quality, blood biochemistry, digestive enzymes, gene expression and intestinal morphology
BackgroundThe rising popularity of eggs as an alternative source of protein to meat has led to significant increase in egg consumption over the past...
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Precision management of acute kidney injury in the intensive care unit: current state of the art
Acute kidney injury (AKI) is a prototypical example of a common syndrome in critical illness defined by consensus. The consensus definition for AKI,...
