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Elucidating the role of circNFIB in myocardial fibrosis alleviation by endogenous sulfur dioxide
BackgroundTo investigate the role of circNFIB in the alleviation of myocardial fibrosis by endogenous sulfur dioxide (SO 2 ).
MethodsWe stimulated...
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Non-Coding RNA-Mediated Gene Regulation in Cardiovascular Disorders: Current Insights and Future Directions
Cardiovascular diseases (CVDs) pose a significant burden on global health. Develo** effective diagnostic, therapeutic, and prognostic indicators...
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Targeting circular RNAs as a therapeutic approach: current strategies and challenges
Significant progress has been made in circular RNA (circRNA) research in recent years. Increasing evidence suggests that circRNAs play important...
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The Function and Therapeutic Potential of Circular RNA in Cardiovascular Diseases
Circular RNA (circRNA) has a closed-loop structure, and its 3’ and 5’ ends are directly covalently connected by reverse splicing, which is more...
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Circular RNAs as potential theranostics in the cardiac fibrosis
Circular RNAs (circRNAs) are a type of single-stranded RNA molecules that normally do not encode proteins. circRNAs are involved in many...
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Role of Circular RNAs in the Pathogenesis of Cardiovascular Disease
Circular RNAs (circRNAs) are single-strand covalently closed circular noncoding RNAs that are endogenous transcripts generated from linear precursor...
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circCELF1 Inhibits Myocardial Fibrosis by Regulating the Expression of DKK2 Through FTO/m6A and miR-636
The aim of this study is to explore the role of circCELF1/miR-636/DKK2 pathway in myocardial fibrosis (MF). RT-qPCR and western blot were used to...
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Circular RNA mmu_circ_0005019 inhibits fibrosis of cardiac fibroblasts and reverses electrical remodeling of cardiomyocytes
BackgroundCircular RNA (circRNA) have been reported to play important roles in cardiovascular diseases including myocardial infarction and heart...
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Epigenetic regulation in cardiovascular disease: mechanisms and advances in clinical trials
Epigenetics is closely related to cardiovascular diseases. Genome-wide linkage and association analyses and candidate gene approaches illustrate the...