Search
Search Results
-
Transferrin receptor 1 promotes the fibroblast growth factor receptor-mediated oncogenic potential of diffused-type gastric cancer
Diffuse-type gastric cancer (DGC) is a highly invasive subtype of gastric adenocarcinoma that frequently exhibits scattered peritoneal metastasis....
-
TfR1 mediated iron metabolism dysfunction as a potential therapeutic target for osteoarthritis
ObjectiveTransferrin receptor-1 (TfR1) plays important roles in controlling cellular iron levels, but its role in OA pathology is unknown. Herein we...
-
TFR1 knockdown alleviates iron overload and mitochondrial dysfunction during neural differentiation of Alzheimer’s disease-derived induced pluripotent stem cells by interacting with GSK3B
Iron metabolism disorders are implicated in the pathogenesis of Alzheimer’s disease (AD). It was previously reported that transferrin receptor (TFR1)...
-
A review on the research progress of traditional Chinese medicine with anti-cancer effect targeting ferroptosis
Ferroptosis is a non-apoptotic form of regulated cell death characterized by iron-dependent lipid peroxidation. It can be triggered by various...
-
TfR1 Extensively Regulates the Expression of Genes Associated with Ion Transport and Immunity
Transferrin receptor 1 (TfR1), encoded by the TFRC gene, is the gatekeeper of cellular iron uptake for cells. A variety of molecular mechanisms are...
-
Amino acid influx via LAT1 regulates iron demand and sensitivity to PPMX-T003 of aggressive natural killer cell leukemia
Aggressive natural killer cell leukemia (ANKL) is a rare hematological malignancy with a fulminant clinical course. Our previous study revealed that...
-
Prevotella histicola suppresses ferroptosis to mitigate ethanol-induced gastric mucosal lesions in mice
BackgroundEthanol-induced gastric mucosal lesions (EGML) is one of the most common digestive disorders for which current therapies have limited...
-
Transferrin receptor-1 and VEGF are prognostic factors for osteosarcoma
BackgroundOsteosarcoma is aggressive and prognostic biomarkers are important to predict the outcomes of surgery and chemotherapy. Here, we...
-
Transferrin receptor 1 targeted optical imaging for identifying glioma margin in mouse models
ObjectiveOptical molecular imaging technology that indiscriminately detects intracranial glioblastoma (GBM) can help neurosurgeons effectively remove...
-
Cross-reactivity to glutamate carboxypeptidase III causes undesired salivary gland and kidney uptake of PSMA-targeted small-molecule radionuclide therapeutics
PurposeRecently, Pluvicto™ ([ 177 Lu]Lu-PSMA-617), a small-molecule prostate-specific membrane antigen (PSMA) radioligand therapeutic, has been...
-
Application of 89Zr-DFO*-immuno-PET to assess improved target engagement of a bispecific anti-amyloid-ß monoclonal antibody
PurposeThe recent conditional FDA approval of Aducanumab (Adu) for treating Alzheimer’s disease (AD) and the continued discussions around that...
-
Uptake of H-ferritin by Glioblastoma stem cells and its impact on their invasion capacity
PurposeIron acquisition is key to maintaining cell survival and function. Cancer cells in general are considered to have an insatiable iron need....
-
Iron and iron-related proteins in COVID-19
COVID-19 can cause detrimental effects on health. Vaccines have helped in reducing disease severity and transmission but their long-term effects on...
-
3-AP inhibits the growth of human osteosarcoma by decreasing the activity of the iron-dependent pathway
3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP) has broad-spectrum antitumor activity. However, its role in osteosarcoma (OS) remains...
-
Specificity protein 1-mediated ACSL4 transcription promoted the osteoarthritis progression through suppressing the ferroptosis of chondrocytes
BackgroundChondrocytes are the main cell damage type involved in the occurrence and development of osteoarthritis (OA). Ferroptosis has been...
-
The mutual crosstalk between iron and erythropoiesis
Iron homeostasis and erythropoiesis are strongly interconnected. On one side iron is essential to terminal erythropoiesis for hemoglobin production,...
-
Dysregulation of iron homeostasis in airways associated with persistent preschool wheezing
BackgroundCurrently, there are no reliable clinical tools available to identify persistent asthma symptoms among preschool children with recurrent...
-
Piezo1 channel exaggerates ferroptosis of nucleus pulposus cells by mediating mechanical stress-induced iron influx
To date, several molecules have been found to facilitate iron influx, while the types of iron influx channels remain to be elucidated. Here, Piezo1...
-
Alterations of the expression levels of glucose, inflammation, and iron metabolism related miRNAs and their target genes in the hypothalamus of STZ-induced rat diabetes model
BackgroundThe hypothalamus of the central nervous system is implicated in the development of diabetes due to its glucose-sensing function....
-
Molecular insights into placental iron transfer mechanisms and maternofetal regulation
PurposeAdequate iron transportation from the mother across the placenta is crucial for fetal growth and establishing sufficient iron stores in...
