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Effects of pharmacological and genetic regulation of COMT activity in alcohol use disorder: a randomized, placebo-controlled trial of tolcapone
Alcohol Use Disorder (AUD) is characterized by loss of control over drinking. Behavioral control is mediated, in part, by cortical dopamine...
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Clinical benefit of MAO-B and COMT inhibition in Parkinson’s disease: practical considerations
Inhibitors of monoamine oxidase B (MAO-B) and catechol-O-methyltransferase (COMT) are major strategies to reduce levodopa degradation and thus to...
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Cortical dopamine reduces the impact of motivational biases governing automated behaviour
Motivations shape our behaviour: the promise of reward invigorates, while in the face of punishment, we hold back. Abnormalities of motivational...
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Working memory, cortical dopamine tone, and frontoparietal brain recruitment in post-traumatic stress disorder: a randomized controlled trial
Post-traumatic stress disorder (PTSD) leads to impairments in both cognitive and affective functioning. Animal work suggests that chronic stress...
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COMT Inhibitors in the Management of Parkinson’s Disease
Levodopa treatment remains the gold standard for Parkinson’s disease, but shortcomings related to the pharmacological profile, notably, oral...
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The Catechol O-Methyltransferase Inhibitor Entacapone in the Treatment of Parkinson’s Disease: Personal Reflections on a First-in-Class Drug Development Programme 40 Years On
In the 1980s, Orion Pharma, then a mid-ranking Nordic area pharmaceutical company, established a drug development programme on the inhibition of...
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Factors associated with a placebo effect in Parkinson’s disease in clinical trials: a meta-analysis
ObjectivesOutcomes of clinical trials of treatment in patients with Parkinson’s disease (PD) may be influenced by placebo effects. The aim of this...
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Treatment Updates for Neuropathy in Hereditary Transthyretin Amyloidosis
Purpose of reviewTo present an overview of current and upcoming therapies for hereditary transthyretin-mediated amyloidosis with peripheral...
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Catechol-O-Methyltransferase Effects on Smoking: a Review and Proof of Concept of Sex-Sensitive Effects
Purpose of ReviewThis article reviews recent research on how catechol- O -methyltransferase (COMT) may impact cigarette smoking behavior, and how...
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Targeted treatments of AL and ATTR amyloidosis
The therapeutic landscape for cardiac amyloidosis is rapidly evolving. In the last decade, our focus has shifted from dealing with the inevitable...
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Homocysteine, vitamin B metabolites, dopamine-substituting compounds, and symptomatology in Parkinson’s disease: clinical and therapeutic considerations
Emerging studies suggest a correlation between elevated plasma homocysteine (hcy) levels and the risk of atherosclerosis, vascular disorders, and...
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Effects of COMT genotype and tolcapone on lapses of sustained attention after sleep deprivation in healthy young men
Tolcapone, a brain penetrant selective inhibitor of catechol- O -methyltransferase (COMT) devoid of psychostimulant properties, improves cognition and...
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Pharmacological Interventions for Impulsivity in Addictive Disorders
Purposeof ReviewNew treatment approaches are needed for addictive disorders. There is a clear link between trait impulsivity and addictions, and...
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Opicapone for the Treatment of Parkinson’s Disease "Off" Episodes: Pharmacology and Clinical Considerations
Parkinson's disease (PD) is a common neurodegenerative disorder. It is also the fastest-growing neurodegenerative disorder and has more than doubled...
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Distinct roles for dopamine clearance mechanisms in regulating behavioral flexibility
Dopamine plays a crucial role in adaptive behavior, and dysfunctional dopamine is implicated in multiple psychiatric conditions characterized by...
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Implications of dopaminergic medication withdrawal in Parkinson’s disease
The trajectory of the use of dopamine replacement therapy (DRT) in Parkinson’s disease (PD) is variable and doses may need to be increased, but also...
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Clinical Use of On-Demand Therapies for Patients with Parkinson’s Disease and OFF Periods
On-demand therapies for Parkinson’s disease (PD) provide rapid, reliable relief for patients experiencing OFF periods; however, practical guidelines...
