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Clinical and therapeutic outcomes of pediatric pituitary adenomas: a single pituitary center experience
PurposePediatric pituitary adenomas (PPA) are rare. Although PPAs are mostly benign, they can be challenging to manage. Most studies evaluating PPA...
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Immunological signatures and predictive biomarkers for first-generation somatostatin receptor ligand resistance in Acromegaly
PurposePredicting resistance to first-generation Somatostatin Receptor Ligands (fg-SRL) in Acromegaly patients remains an ongong challenge....
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A prospective study on the efficacy of oral estrogen in female patients with acromegaly
PurposeTo evaluate the efficacy and safety of oral estrogen therapy in female patients of childbearing age with uncontrolled acromegaly and to verify...
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The learning curve for endoscopic endonasal pituitary surgery: a systematic review
Recent literature demonstrates that a learning curve exists for endoscopic pituitary surgery. However, there is significant variability in the way...
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Pituitary macroadenomas in childhood and adolescence: a clinical analysis of 7 patients
BackgroundPituitary adenomas (PPAs) are uncommon in childhood and adolescence, accounting for 2–6% of all intracranial neoplasms. Delayed puberty,...
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Malignant paraganglioma and somatotropinoma in a patient with germline SDHB mutation—genetic and clinical features
BackgroundPituitary adenomas and paragangliomas/pheocromocytomas are rare endocrine tumours, which can be sporadic or familial. During many years...
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Pediatric pituitary adenomas are more aggressive, more likely to be hormone producing and are more difficult to cure than adult pituitary adenomas: case series and systematic literature review
PurposePediatric pituitary adenomas (pPAs) are uncommon. Thus, their presentation and outcomes after treatment are less well-understood than those of...
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Equivalent outcomes in nasal symptoms following microscopic or endoscopic transsphenoidal surgery: results from multi-centre, prospective study
BackgroundT ranssphenoidal surgery (TSS) is the standard approach for resection of pituitary lesions. Historically, this has utilized the microscopic...
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Germline AIP variants in sporadic young acromegaly and pituitary gigantism: clinical and genetic insights from a Han Chinese cohort
PurposeVariants in the Aryl hydrocarbon receptor-interacting protein ( AIP ) gene have been identified in sporadic acromegaly and pituitary gigantism,...
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High prevalence of morphometric vertebral fractures opportunistically detected on thoracic radiograms in patients with non-functioning pituitary adenoma
PurposeVertebral fractures (VFs), the hallmark of skeletal fragility, have been reported as an emerging complication in patients with pituitary...
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Global changes in chromatin accessibility and transcription in growth hormone-secreting pituitary adenoma
PurposeGrowth hormone-secreting pituitary adenoma (GHPA) is an insidious disease with persistent hypersecretion of growth hormone and insulin-like...
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Genomics and Epigenomics of Pituitary Tumors: What Do Pathologists Need to Know?
Molecular pathology has advanced our understanding of many tumors and offers opportunities to identify novel therapies. In the pituitary, the field...
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Clinical aspects of multiple endocrine neoplasia type 1
Multiple endocrine neoplasia type 1 (MEN1) is a rare syndrome characterized by the co-occurrence of primary hyperparathyroidism, duodenopancreatic...
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Imaging of pituitary tumors: an update with the 5th WHO Classifications—part 1. Pituitary neuroendocrine tumor (PitNET)/pituitary adenoma
The pituitary gland is the body’s master gland of the endocrine glands. Although it is a small organ, many types of tumors can develop within it. The...
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Familial states of primary hyperparathyroidism: an update
BackgroundFamilial primary hyperparathyroidism (PHPT) includes syndromic and non-syndromic disorders. The former are characterized by the occurrence...
