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Severe congenital neutropenia due to G6PC3 deficiency: early and delayed phenotype of a patient
BackgroundSevere Congenital Neutropenia type 4 (SCN4), is a rare autosomal recessive condition, due to mutations in the G6PC3 gene. The phenotype...
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Extracorporeal membrane oxygenation in long-term COVID-19 with severe neutropenia and thrombocytopenia after allogeneic hematopoietic stem cell transplantation: a case report
BackgroundHematopoietic stem cell transplantation (HSCT) was associated with potentially life-threatening complications. Among patients supported by...
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Non-cancer febrile neutropenia in children: pathogens, antimicrobial susceptibilities, and outcomes
BackgroundFebrile neutropenia is a medical emergency and remains a significant cause of morbidity and mortality, it is defined as a...
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Incidence, predictors, and outcomes of febrile neutropenia and neutropenia in patients with metastatic castrate-resistant prostate cancer receiving docetaxel
PurposeThe incidence of febrile neutropenia (FN) in adults with castrate-resistant metastatic prostate cancer (mCRPC) receiving docetaxel in...
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Paediatric autoimmune diseases with ELANE mutations associated with neutropenia
ObjectiveTo explore the clinical characteristics of autoimmune diseases in children with ELANE mutations.
MethodsThree cases of children with ELANE...
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The prevalence of neutropenia and association with infections in patients with systemic lupus erythematosus: a Swedish single-center study conducted over 14 years
Hematologic abnormalities are common manifestations of SLE, although neutropenia is observed less frequently and is not included in the...
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Genetic susceptibility to breast cancer increases the risk of neutropenia and agranulocytosis: insights from Mendelian randomization
PurposeThe causal relationship between breast cancer and its estrogen receptor (ER) subtypes and neutropenia and agranulocytosis is unclear.
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Clinical significance of human neutrophil antigen-1 antibodies in children with neutropenia
Primary autoimmune neutropenia in young children is characterized by chronic neutropenia and positivity for antibodies against human neutrophil...
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What is the role of neutropenia in pediatric cancer patients with pneumatosis intestinalis?
BackgroundWe aimed to identify prognostic indicators in pneumatosis intestinalis (PI) in a pediatric oncology population. We hypothesized that...
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A prospective, real-world, multinational study of febrile neutropenia (FN) occurrence in oncology patients receiving chemotherapy with intermediate risk of FN: a MASCC Neutropenia, Infection, and Myelosuppression Study Group initiative
PurposeLimited knowledge is available on the incidence of febrile neutropenia (FN) in intermediate-risk patients and the rationale for use of...
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Cyclic neutropenia and concomitant IgA nephropathy: a case report
BackgroundIgA nephropathy (IgAN) is universally recognized as one of the most common primary glomerular diseases in all ages. Cyclic neutropenia (CN)...
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New approaches to idiopathic neutropenia in the era of clonal hematopoiesis
Isolated chronic idiopathic neutropenia (CIN) is a rare disease with multiple contributing etiologies that must be ruled out before establishing a...
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CT-determined sarcopenia is associated with neutropenia in patients undergoing hyperthermic intraperitoneal chemotherapy for gastrointestinal cancer
BackgroundWith better patient selection and the increasing experience in patients undergoing hyperthermic intraperitoneal chemotherapy (HIPEC)...
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Effect of lithium on chemotherapy-induced neutropenia in Egyptian breast cancer patients; a prospective clinical study
PurposeMyelosuppressive chemotherapy-induced neutropenia (CIN) remains a major limitation of cancer treatment efficacy, necessitating very expensive...
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Efbemalenograstim alfa, an Fc fusion protein, long-acting granulocyte-colony stimulating factor for reducing the risk of febrile neutropenia following chemotherapy: results of a phase III trial
PurposeEvaluate the safety and efficacy of efbemalenograstim alfa for reducing the risk of febrile neutropenia in breast cancer patients undergoing...
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Overexposure to venetoclax is associated with prolonged-duration of neutropenia during venetoclax and azacitidine therapy in Japanese patients with acute myeloid leukemia
PurposeAn observational study was conducted to evaluate the pharmacokinetics of venetoclax and its impact on the efficacy and safety for Japanese...
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Low utilization of vancomycin in febrile neutropenia: real-world evidence from 4 Brazilian centers
PurposeThe prompt initiation of a betalactam antibiotic in febrile neutropenic patients is considered standard of care, while the empiric use of...
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Ambulatory management of low-risk febrile neutropenia in adult oncological patients. Systematic review
PurposeRecent clinical practice guidelines have recommended ambulatory management of febrile neutropenia in patients with low risk of complications....
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Prevalence of neutropenia in US residents: a population based analysis of NHANES 2011–2018
AimsNeutrophils play a pivotal in immunity and inflammation. We aim to investigate the prevalence of neutropenia in the United States.
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Quality of life and patient-reported outcomes in chronic severe neutropenia conditions
Quality of life (QOL) and patient-reported outcomes (PROs) assessments in immunodeficiency patients, including those with chronic severe neutropenia...