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SPARC accelerates biliary tract cancer progression through CTGF-mediated tumor–stroma interactions: SPARC as a prognostic marker of survival after neoadjuvant therapy
PurposeIn biliary tract cancer (BTC), malignancy is strongest at the invasion front. To improve the BTC prognosis, the invasion front should be...
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Downregulation of SPARC Expression Enhances the Fusion of BeWo Choriocarcinoma Cells
Syncytiotrophoblasts, which are formed by the fusion of villous cytotrophoblasts, play an essential role in maintaining a successful pregnancy....
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Diosgenin restores memory function via SPARC-driven axonal growth from the hippocampus to the PFC in Alzheimer’s disease model mice
Central nervous system axons have minimal capacity to regenerate in adult brains, hindering memory recovery in Alzheimer’s disease (AD). Although...
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Alteration of BDNF, SPARC, FGF-21, and GDF-15 circulating levels after 1 year of anti-obesity treatments and their association with 1-year weight loss
PurposeEmerging evidence revealed that brain-derived neurotrophic factor (BDNF), secreted protein acidic and rich in cysteine (SPARC), fibroblast...
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SCD5-dependent inhibition of SPARC secretion hampers metastatic spreading and favors host immunity in a TNBC murine model
Dysregulated fatty acid metabolism interacts with oncogenic signals, thereby worsening tumor aggressiveness. The stearoyl-CoA desaturating enzymes,...
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TAK-242 treatment and its effect on mechanical properties and gene expression associated with IVD degeneration in SPARC-null mice
PurposeIntervertebral disc (IVD) degeneration is accompanied by mechanical and gene expression changes to IVDs. SPARC-null mice display accelerated...
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Suprapubic arc(SPARC)-Operation zur Behandlung der weiblichen Belastungsinkontinenz
Stress urinary incontinence shows a significant prevalence in adult women, having a major impact on quality of life and healthcare systems. A trend...
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Comparison of lateral flank approach and low anterior access for single port (SP) retroperitoneal partial nephrectomy: an analysis from the single port advanced research consortium (SPARC)
Single Port (SP) robotic partial nephrectomy (RPN) can be performed via retroperitoneal and transperitoneal approach. We aim to compare outcomes of...
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Osteogenesis imperfecta type XVII: expansion of the phenotype
BackgroundBiallelic variants in SPARC are extremely rare, and have been reported in only a few cases of autosomal recessive osteogenesis imperfecta...
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Instrumental evaluation of gait smoothness and history of falling in older persons: results from an exploratory case–control study
Gait smoothness, perceived when a person walks continuously and uninterruptedly, is associated with an undisrupted gait pattern, good sensorimotor...
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Osteonectin bidirectionally regulates osteoblast mineralization
ObjectiveThe aim of this study was to investigate whether Osteonectin/Secreted protein acidic and rich in cysteine (ON/SPARC) had a two-way...
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Effect of a 3-month L-carnitine supplementation and resistance training program on circulating markers and bone mineral density in postmenopausal women: a randomized controlled trial
BackgroundHigher circulating levels of trimethylamine N-oxide (TMAO), which is a metabolite that can be produced by the gut microbiota from...
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The impact of mild hypoxia exposure on myokine secretion in human obesity
Background/ObjectiveCompelling evidence indicates that myokines act in an autocrine, paracrine and endocrine manner to alter metabolic homeostasis....
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Differential Expression of Super-Enhancer-Associated Long Non-coding RNAs in Uterine Leiomyomas
Super-enhancer-associated long non-coding RNAs (SE-lncRNAs) are a specific set of lncRNAs transcribed from super-enhancer (SE) genomic regions....
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Correlation Between Serum and Fecal Biomarkers and Patient-Reported Outcomes in Patients with Crohn’s Disease and Ulcerative Colitis
BackgroundPatient-reported outcomes (PROs), such as the short CD activity index (sCDAI) and partial Mayo Score (PMS), are used to define clinical...
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Establishment and characterization of a canine chondrosarcoma cell line: Mango
In the global progress of bone tumor research, established stable and long-lasting transgenic chondrosarcoma (CSA) cell lines are rare, mainly of...
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Thyroid hormone induces ossification and terminal maturation in a preserved OA cartilage biomimetic model
ObjectiveTo characterize aspects of triiodothyronine (T3) induced chondrocyte terminal maturation within the molecular osteoarthritis pathophysiology...
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RhoA regulates translation of the Nogo-A decoy SPARC in white matter-invading glioblastomas
Glioblastomas strongly invade the brain by infiltrating into the white matter along myelinated nerve fiber tracts even though the myelin protein...
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Updated efficacy of adjuvant epirubicin plus cyclophosphamide followed by taxanes versus carboplatin plus taxanes in early triple-negative breast cancer in phase 2 trial: 8.1-year median follow-up
BackgroundPaclitaxel/docetaxel after doxorubicin plus cyclophosphamide (ECT) is considered as an adjuvant chemotherapy and improves the survival of...
