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The impact of tubular dysfunction and its relationship with acute kidney injury in children
BackgroundTubular dysfunction can cause electrolyte disturbances with potentially serious consequences. We studied the epidemiology and outcomes of...
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Pediatric early-phase anorexia nervosa without hypokalemia exhibiting acute tubular injury: a case report
Anorexia nervosa can lead to kidney complications. Few studies reported kidney biopsy results in young adults, most of whom had chronic anorexia...
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Protective effect of Cordyceps sinensis against diabetic kidney disease through promoting proliferation and inhibiting apoptosis of renal proximal tubular cells
BackgroundDiabetic kidney disease (DKD) has mainly been considered as a glomerular disease. Our previous study showed that the progression of DKD was...
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The exacerbated hypokalemia in membranous glomerulonephritis due to proximal tubular injury: a neglect issue from a case report and literature review
BackgroundMembranous glomerulonephritis is the most common primary etiology for the nephrotic syndrome in adults. Beyond the clinical hallmark of...
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Renal tubular dysfunction in COVID-19 patients
IntroductionSARS-CoV-2 infection can affect other organs aside from those of respiratory system, particularly the kidney, heart, blood, digestive...
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β-Thalassemia minor & renal tubular dysfunction: is there any association?
ObjectiveBeta(β)-thalassemia is one of the most common hereditary hematologic disorders. Patients with thalassemia minor (TM) are often asymptomatic...
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Adverse effects of acute tubular injury on the glomerulus: contributing factors and mechanisms
The intricate relationship between tubular injury and glomerular dysfunction in kidney diseases has been a subject of extensive research. While the...
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Evaluation of proximal tubule functions in children with COVID-19: a prospective analytical study
BackgroundThere are limited numbers of studies focusing on renal effects of coronavirus disease 2019 (COVID-19) infection and proximal tubular...
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Comparing different markers of tubular dysfunction in transfusion-dependent thalassemia patients
BackgroundRenal tubular dysfunction was reported in transfusion-dependent thalassemia (TDT) patients and ranges from mild to severe. The objectives...
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Kidney tubular injury induced by valproic acid: systematic literature review
BackgroundValproic acid is prescribed for epilepsy and as prophylaxis for bipolar disorder and migraine headaches. It has also been implicated as a...
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Transcriptional regulation of proximal tubular metabolism in acute kidney injury
The kidney, and in particular the proximal tubule (PT), has a high demand for ATP, due to its function in bulk reabsorption of solutes. In normal PT,...
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More than tubular dysfunction: cystinosis and kidney outcomes
BackgroundCystinosis is a lysosomal storage disease that affects many tissues. Its prognosis depends predominantly on kidney involvement. Cystinosis...
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The pathophysiology of distal renal tubular acidosis
The kidneys have a central role in the control of acid–base homeostasis owing to bicarbonate reabsorption and production of ammonia and ammonium in...
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FFAR4 improves the senescence of tubular epithelial cells by AMPK/SirT3 signaling in acute kidney injury
Acute kidney injury (AKI) is a serious clinical complication with high morbidity and mortality rates. Despite substantial progress in understanding...
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Glomerular podocyte dysfunction in inherited renal tubular disease
BackgroundHereditary renal tubular disease can cause hypercalciuria, acid-base imbalance, hypokalemia, hypomagnesemia, rickets, kidney stones, etc....
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Distal renal tubular acidosis as presenting manifestation of Wilson disease in a 11-year-old girl
A 11-year-old girl was referred to the pediatric nephrology services of our hospital for evaluation of vitamin-D-refractory rickets. She was born to...
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Relationship between biomarkers of tubular injury and intrarenal hemodynamic dysfunction in youth with type 1 diabetes
BackgroundEarly identification of youth with type 1 diabetes (T1D) at risk for diabetic kidney disease may improve clinical outcomes. We examined the...
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Evaluation of kidney dysfunction in childhood cancer survivors
BackgroundThe major increase in the survival rate among children with cancer is due to improvement in the diagnosis and treatment. Despite this...
