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An unusual case of primary tuberculosis of the patella and patellar tendon masquerading as gout
Tuberculosis (TB), an infection caused by Mycobacterium tuberculosis , accounts for significant morbidity and mortality worldwide. While primary TB...
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Response to febuxostat according to clinical subtypes of hyperuricemia: a prospective cohort study in primary gout
BackgroundWhile xanthine oxidase inhibitors target uric acid production, renal urate underexcretion is the predominant subtypes in gout. This study...
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Association between gout and subsequent breast cancer: a retrospective cohort study including 67,598 primary care patients in Germany
PurposeThe aim of this retrospective cohort study was to analyze the cumulative incidence of breast cancer following gout and to investigate the...
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Prednisolone Versus Colchicine for Acute Gout in Primary Care: statistical analysis plan for the pragmatic, multicenter, randomized, and double-blinded COPAGO non-inferiority trial
BackgroundTo date, colchicine and prednisolone are two effective therapies for the treatment of acute gout but have never been compared directly in a...
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Risk of gout in Taiwan Biobank participants pertaining to their sex and family history of gout among first-degree relatives
BackgroundFamily history of gout and sex are independently associated with gout. However, there is a paucity of research regarding the joint role of...
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Correlation between gout and dry eye disease
BackgroundGout is a common form of inflammatory arthritis that can cause a number of serious complications. Complications are common in patients with...
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Pipeline Therapies for Gout
Purpose of ReviewDespite effective available treatments, gout management is often unsuccessful in getting patients to target serum urate goal and in...
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Impact of gout on cardiovascular disease mortality: a meta-analysis
BackgroundSeveral epidemiological studies have suggested that gout patients have a higher risk of cardiovascular disease mortality than healthy...
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Causal Association Between Tea Consumption and Gout: A Mendelian Randomization Study
ObjectiveEvidence from prospective studies on the consumption of tea and risk of gout is conflicting and limited. We aimed to investigate the...
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Prednisolone Versus Colchicine for Acute Gout in Primary Care (COPAGO): protocol for a two-arm multicentre, pragmatic, prospective, randomized, double-blind, controlled clinical trial of prednisolone and colchicine for non-inferiority with a parallel group design
BackgroundGout is the most common form of rheumatic disease in which monosodium urate crystals are deposited in the joints followed by acute...
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Cohort study investigating gout flares and management in UK general practice
BackgroundGout is the most common inflammatory arthritis and is almost exclusively managed in primary care, however the course and severity of the...
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Interleukin-37: associations of plasma levels and genetic variants in gout
ObjectivesIL-37 is an anti-inflammatory cytokine involved in inflammatory and autoimmune diseases. We aimed to investigate the association between...
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The clinical benefits of sodium–glucose cotransporter type 2 inhibitors in people with gout
Gout is the most common form of inflammatory arthritis worldwide and is characterized by painful recurrent flares of inflammatory arthritis that are...
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The pathogenesis of gout: molecular insights from genetic, epigenomic and transcriptomic studies
The pathogenesis of gout involves a series of steps beginning with hyperuricaemia, followed by the deposition of monosodium urate crystal in...
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Mechanisms and rationale for uricase use in patients with gout
Xanthine oxidase inhibitors such as allopurinol and febuxostat have been the mainstay urate-lowering therapy (ULT) for treating hyperuricaemia in...
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Emerging Urate-Lowering Drugs and Pharmacologic Treatment Strategies for Gout: A Narrative Review
Hyperuricemia with consequent monosodium urate crystal deposition leads to gout, characterized by painful, incapacitating inflammatory arthritis...
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Single-cell and genome-wide Mendelian randomization identifies causative genes for gout
BackgroundGout is a prevalent manifestation of metabolic osteoarthritis induced by elevated blood uric acid levels. The purpose of this study was to...
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Sodium glucose cotransporter 2 inhibitors and gout risk: a sequence symmetry analysis
ObjectiveTo examine the association between sodium-glucose cotransporter 2 inhibitors (SGLT2-I) and gout incidence in patients with diabetes is the...
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Association between Impella device support and elevated rates of gout flares: a retrospective propensity-matched study
BackgroundImpella is an advanced ventricular assist device frequently used as a bridge to heart transplantation. The association of Impella with...
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Elevated serum IL-2 and Th17/Treg imbalance are associated with gout
Gout is considered an auto-inflammatory disorder, and the immunological drivers have not been fully unraveled. This study compared the peripheral...
