Search
Search Results
-
Tetrastigma hemsleyanum (Sanyeqing) root extracts evoke S phase arrest while inhibiting the migration and invasion of human pancreatic cancer PANC-1 cells
BackgroundEthyl acetate extracts from Tetrastigma hemsleyanum (Sanyeqing) (EFT), a member of the Vitaceae plant family, have been shown to exhibit...
-
A pharmacognostic approach for mitigating pancreatic cancer: emphasis on herbal extracts and phytoconstituents
BackgroundPancreatic cancer is studied as one of the most lethal cancers with currently no control of its lethality, mainly due to its late diagnosis...
-
The role of AMPK in pancreatic cancer: from carcinogenesis to treatment
Pancreatic cancer has doubled over the previous two decades. Routine therapies are becoming incredibly resistant and failing to compensate for the...
-
Oxidative stress promotes cytotoxicity in human cancer cell lines exposed to Escallonia spp. extracts
BackgroundStandard cancer treatments show a lack of selectivity that has led to the search for new strategies against cancer. The selective...
-
In vivo antidiabetic and antioxidant activities of Prosopis africana fruit extracts in streptozotocin-induced diabetic Wistar rats
The effect of Prosopis africana fruit extracts on biochemical indices, blood glucose level, lipid profile, and its antioxidant potentials in diabetic...
-
Detection of HHV-6 Virus in specimen of a ductal pancreatic adenocarcinoma with comparison in tumor and normal tissue
AimsThe association of human herpesvirus 6 (HHV-6) species with pancreatic cancer is controversially discussed. The aim of this study was to further...
-
Effect of PAWI-2 on pancreatic cancer stem cell tumors
Worldwide, pancreatic cancer (PC) is a major health problem and almost 0.5 million people were diagnosed with PC in 2020. In the United States, more...
-
Current status of Complementary and Alternative Medicine Interventions in the Management of Pancreatic Cancer – An Overview
Pancreatic cancer (PC) remains the deadliest cancer worldwide. Most patients are diagnosed at the advanced or metastatic stage, leading to a poor...
-
CT-based pancreatic radiomics predicts secondary loss of response to infliximab in biologically naïve patients with Crohn’s disease
ObjectivesPredicting secondary loss of response (SLR) to infliximab (IFX) is paramount for tailoring personalized management regimens. Concurrent...
-
Melatonin improves liver and pancreatic tissue injuries in diabetic rats: role on antioxidant enzymes
PurposeMelatonin (Mel) is an indolamine mainly synthesized by the pineal gland and many other organs. It plays an important role in scavenging free...
-
Anti-apoptotic effect of Buchholzia coriacea Engl. stem back extracts on AsPC-1 and mechanisms of action
Ethnopharmacological relevanceBuchholzia coriacea Engl. is popularly called wonderful cola due to its wide ethnomedicinal use for the treatment of...
-
Upregulated GPRC5A disrupting the Hippo pathway promotes the proliferation and migration of pancreatic cancer cells via the cAMP-CREB axis
BackgroundPancreatic cancer has a high mortality rate worldwide, and is predicted to be third leading cause of death in the near future. However, the...
-
Lipidomics and pancreatic cancer risk in two prospective studies
Pancreatic ductal carcinoma (PDAC) is highly fatal with limited understanding of mechanisms underlying its carcinogenesis. We comprehensively...
-
Ameliorative effect of extracts from scent (Ocimum basilicum), mentha (Mentha piperita), and thyme (Thymus vulgaris) leafy spices on glycemic, purinergic molecules, and oxidative status in renal tissue of diabetic rats
Kidney is a homeostasis organ in vertebrates involved in metabolizing and excreting molecules in the system. Diabetes is a known clinical disease...
-
High expression of the glutathione S-transferase A2 and neuropilin-2 genes affects pancreatic islet β-cell function
ObjectiveType 2 diabetes mellitus (T2DM) seriously affects human life and health. The aim of this study is to investigate the molecular mechanisms...
-
Elucidation of possible mechanisms of the antidiabetic potential of Zn-loaded Bryophyllum pinnatum (Lam.) extracts in experimental animal models
BackgroundThe present study focused on the antidiabetic potential and fingerprinting analysis of Bryophyllumc pinnatum stems as well as its possible...
-
Novel therapeutic strategies and perspectives for pancreatic cancer: Autophagy and apoptosis are key mechanisms to fight pancreatic cancer
Pancreatic cancer (PC) is the most lethal malignancy of the gastrointestinal tract. The poor prognosis of patients with PC is primarily due to lack...
-
The radiomorphological appearance of the invasive margin in pancreatic cancer is associated with tumor budding
PurposePancreatic cancer (PDAC) is characterized by infiltrative, spiculated tumor growth into the surrounding non-neoplastic tissue. Clinically, its...
-
Activation of Vitamin D/VDR Signaling Reverses Gemcitabine Resistance of Pancreatic Cancer Cells Through Inhibition of MUC1 Expression
BackgroundPancreatic ductal adenocarcinoma (PDA) has a poor prognosis due to its therapeutic resistance. Inactivation of vitamin D/vitamin D receptor...
-
Anticancer properties and metabolomic profiling of Shorea roxburghii extracts toward gastrointestinal cancer cell lines
BackgroundGastrointestinal cancer (GIC) ranks as the highest cause of cancer-related deaths globally. GIC patients are often diagnosed at advanced...
