Search
Search Results
-
Low microsatellite instability: A distinct instability type in gastric cancer?
PurposeWe recently showed that low microsatellite instability (MSI-L) is associated with a good response to platinum/5-fluorouracil (5-FU)...
-
Microsatellite instability in gastric cancer: molecular features and clinical implications
Gastric cancer (GC), a molecularly and phenotypically highly heterogeneous malignancy, is a leading cause of cancer-related deaths. The Cancer Genome...
-
Molecular features and prognostic factors of locally advanced microsatellite instability-high gastric cancer
BackgroundMicrosatellite instability-high (MSI-H) tumors are distinct molecular subtypes in gastric cancer. However, a few studies have...
-
Histopathological Predictors of Microsatellite Instability in Colorectal Cancer—a Tertiary Care Center Experience
Microsatellite instability (MSI) has a therapeutic and prognostic implication in colorectal carcinomas (CRCs). It can be detected either by...
-
Genetic diversity and forensic characterization of 15 autosomal microsatellite markers in the North-east Indian Tripuri population
This study was conducted to explore the genomic diversity and forensic characterization of 15 autosomal microsatellite markers in the East Indian...
-
An extensive immunohistochemical analysis of 290 ovarian adult granulosa cell tumors with 29 markers
The current knowledge about the immunohistochemical features of adult granulosa cell tumor (AGCT) is mostly limited to the “traditional”...
-
Molecular characteristics of microsatellite stable early-onset colorectal cancer as predictors of prognosis and immunotherapeutic response
The incidence of early-onset colorectal cancer (EO-CRC, in patients younger than 50) is increasing worldwide. The specific gene signatures in EO-CRC...
-
PD-L1 expression and microsatellite instability (MSI) in cancer of unknown primary site
BackgroundCancer of unknown primary site (CUP) is a heterogeneous group of tumors for which the origin remains unknown. Clinical outcomes might be...
-
Detecting mismatch repair deficiency in solid neoplasms: immunohistochemistry, microsatellite instability, or both?
In managing patients with solid tumors, the value of detecting the status of tumor DNA mismatch repair function is widely recognized. Mismatch repair...
-
Pembrolizumab response in stage IV luminal-type breast cancer with high microsatellite instability: a case report
BackgroundPembrolizumab (PEM), an immune checkpoint inhibitor (ICI), is often used for triple-negative breast cancer, but can also be used to treat...
-
Microsatellite instability in patients with hepato-biliary-pancreatic malignancies in clinical practice (KHBO 1903)
BackgroundThis study aimed to determine the prevalence of microsatellite instability (MSI)-high status in hepato-biliary-pancreatic malignancies in...
-
Discordant microsatellite instability findings in two samples from a patient with biliary cancer that responded to pembrolizumab
Microsatellite instability (MSI) is a key marker to predict response to immune checkpoint inhibitors; however, only 1–2% of biliary cancers have this...
-
Microsatellite instability in the high-grade dysplasia component of duodenal adenoma is associated with progression to adenocarcinoma
PurposeWe examined the microsatellite instability of duodenal tumors to evaluate their molecular features associated with the adenoma–carcinoma...
-
Forensic short tandem repeat markers alteration in cancerous tissues: a sco** review
BackgroundShort Tandem Repeats (STRs) are segments of DNA composed of a short sequence of nucleotides that repeat consecutively. These repeating...
-
The prognostic significance of microsatellite instability in colorectal cancer: a Swedish multi-center study
PurposeAbout 10 to 15% of patients with sporadic colorectal cancer display mutations in DNA mismatch repair (MMR) genes shown as microsatellite...
-
Deep learning to assess microsatellite instability directly from histopathological whole slide images in endometrial cancer
Molecular classification, particularly microsatellite instability-high (MSI-H), has gained attention for immunotherapy in endometrial cancer (EC)....
-
Treatment of hepatocellular carcinoma with a portal vein tumor thrombus and pulmonary metastases of rectal cancer with microsatellite stability using atezolizumab plus bevacizumab
Herein, we report the successful treatment using atezolizumab plus bevacizumab of a patient with hepatocellular carcinoma (HCC) with a portal vein...
-
ASCL2 induces an immune excluded microenvironment by activating cancer-associated fibroblasts in microsatellite stable colorectal cancer
Proficient mismatch repair or microsatellite stable (pMMR/MSS) colorectal cancers (CRCs) are vastly outnumbered by deficient mismatch repair or...
-
Multisequence magnetic resonance imaging-based radiomics models for the prediction of microsatellite instability in endometrial cancer
PurposeTo evaluate the performance of multisequence magnetic resonance imaging (MRI)-based radiomics models in the assessment of microsatellite...
-
Development and validation of a deep learning-based microsatellite instability predictor from prostate cancer whole-slide images
Microsatellite instability-high (MSI-H) is a tumor-agnostic biomarker for immune checkpoint inhibitor therapy. However, MSI status is not routinely...
