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The efficacy of LED microneedle patch on hair growth in mice
Light penetration depth in the scalp is a key limitation of low-level light therapy for the treatment of androgenetic alopecia (AGA). A novel light...
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A comparative study on a biodegradable hyaluronic acid microneedle patch with a needleless patch for dry skin in atopic dermatitis: a single-blinded, split-body, randomized controlled trial
To overcome interruption of skin barrier in transdermal drug delivery, the microneedle (MN) patch penetrates the barrier by punching with its MNs....
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Wireless facial biosensing system for monitoring facial palsy with flexible microneedle electrode arrays
Facial palsy (FP) profoundly influences interpersonal communication and emotional expression, necessitating precise diagnostic and monitoring tools...
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Efficacy of a triamcinolone acetonide-loaded dissolving microneedle patch for the treatment of hypertrophic scars and keloids: a randomized, double-blinded, placebo-controlled split-scar study
The treatment of hypertrophic scars (HTSs) and keloids remains a challenge. Intralesional triamcinolone acetonide (TAC) is the mainstay treatment for...
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Study protocol for a phase 1/2, single-centre, double-blind, double-dummy, randomized, active-controlled, age de-escalation trial to assess the safety, tolerability and immunogenicity of a measles and rubella vaccine delivered by a microneedle patch in healthy adults (18 to 40 years), measles and rubella vaccine-primed toddlers (15 to 18 months) and measles and rubella vaccine-naïve infants (9 to 10 months) in The Gambia [Measles and Rubella Vaccine Microneedle Patch Phase 1/2 Age De-escalation Trial]
BackgroundNew strategies to increase measles and rubella vaccine coverage, particularly in low- and middle-income countries, are needed if...
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Gelatin–PVP dissolving microneedle-mediated therapy for controlled delivery of nifedipine for rapid antihypertension treatment
Nifedipine has exhibited to be the oldest primary drug having promising therapeutic potential for hypertension, angina pectoris, and pre-eclampsia...
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Minimally Invasive Skin Transcriptome Extraction Using a Dermal Biomarker Patch
IntroductionAdvances in the scientific understanding of the skin and characteristic genomic dermal signatures continue to develop rapidly....
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Clinical efficacy of adipocyte-derived stem cells conditioned media combined with micro-injury in refractory patch of alopecia areata
Management of alopecia areata (AA) is often challenging especially when patients have AA lesion refractory to conventional treatments such as...
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Optimizing the design of a contraceptive microarray patch: a discrete choice experiment on women’s preferences in India and Nigeria
BackgroundEfforts are underway to develop an easy-to-use contraceptive microarray patch (MAP) that could expand the range of self-administrable...
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Emerging era of microneedle array for pharmaceutical and biomedical applications: recent advances and toxicological perspectives
BackgroundMicroneedles (MNs) are the utmost unique, efficient, and minimally invasive inventions in the pharmaceutical field. Over the past decades,...
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Biomimetic microneedles: exploring the recent advances on a microfabricated system for precision delivery of drugs, peptides, and proteins
BackgroundDespite its popularity, acceptability, and convenience, the oral route is not the classical route for the administration of all critical...
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Low cost additive manufacturing of microneedle masters
PurposeMicroneedle patches are arrays of tiny needles that painlessly pierce the skin to deliver medication into the body. Biocompatible microneedles...
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Novel concepts and improvisation for treating postpartum haemorrhage: a narrative review of emerging techniques
BackgroundMost treatments for postpartum haemorrhage (PPH) lack evidence of effectiveness. New innovations are ubiquitous but have not been...
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Long term safety, tolerability, and efficacy of intracutaneous zolmitriptan (M207) in the acute treatment of migraine
ObjectiveTo determine the long-term safety and tolerability profile of M207 in the acute treatment of migraine.
BackgroundM207 is an investigational...
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Applications of photodynamic therapy in keratitis
Keratitis is corneal inflammatory disease which may be caused by several reason such as an injury, allergy, as well as a microbial infection. Besides...
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Skin cancer therapeutics: nano-drug delivery vectors—present and beyond
BackgroundSkin cancers are among the widely prevalent forms of cancer worldwide. The increasing industrialization and accompanied environmental...
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Advancing cardiac regeneration through 3D bioprinting: methods, applications, and future directions
Cardiovascular diseases (CVDs) represent a paramount global mortality concern, and their prevalence is on a relentless ascent. Despite the...
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Keloid treatments: an evidence-based systematic review of recent advances
BackgroundKeloids are pathologic scars that pose a significant functional and cosmetic burden. They are challenging to treat, despite the multitude...
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The Future of Food Allergy Management: Advancements in Therapies
Purpose of ReviewTo review current and future treatment options for IgE-mediated food allergy.
Recent FindingsRecent years have seen major...