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The mechanisms of MicroRNA 21 in premature ovarian insufficiency mice with mesenchymal stem cells transplantation
Umbilical cord-derived mesenchymal stem cell (UCMSC) transplantation has been deeply explored for premature ovarian insufficiency (POI) disease....
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Evaluation of serum MicroRNA 21, MicroRNA 192 and serum TGFβ1 in type 2 diabetes mellitus patients and their relation to diabetic nephropathy
BackgroundDiabetic nephropathy (DN) is a frequent and long-lasting microvascular consequence that has an established connection with diabetes. It...
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Role of MicroRNA-21 in Prostate Cancer Progression and Metastasis: Molecular Mechanisms to Therapeutic Targets
The role of noncoding RNA has made remarkable progress in understanding progression, metastasis, and metastatic castration-resistant prostate cancer...
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MicroRNA-21 is immunosuppressive and pro-metastatic via separate mechanisms
MiR-21 was identified as a gene whose expression correlated with the extent of metastasis of murine mammary tumours. Since miR-21 is recognised as...
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A PRISMA meta-analysis for diagnostic value of microRNA-21 in head and neck squamous cell carcinoma along with bioinformatics research
ObjectivesThe use of miR-21 expression remains vague in diagnosis of head and neck squamous cell carcinoma (HNSCC). This study aimed to...
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MicroRNA-21 expression in cancer cells is an independent biomarker of progression-free survival of endometrioid endometrial carcinoma
Endometrial carcinoma is one of the most common gynecological cancers. MicroRNA-21 (miR-21) is the most consistently overexpressed miRNA in almost...
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Regulatory network identified by pulmonary transcriptome and proteome profiling reveals extensive change of tumor-related genes in microRNA-21 knockout mice
PurposeMicroRNA-21 (miR-21) is a well-known oncomiR and plays key roles in regulating various biological processes related to pulmonary diseases,...
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MicroRNA 21 and microRNA 10b: early diagnostic biomarkers of breast cancer in Egyptian females
BackgroundBreast cancer (BC) is one of the most prevalent cancers in develo** and developed countries among women worldwide. Mammography is one of...
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Under-expression of microRNA-146a and 21 and their association with Crohn’s disease
MicroRNAs (miRNAs) can post-transcriptionally regulate gene expression and are involved in the immune response. Excessive immune response to the gut...
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Estimation of Serum MicroRNA 21 as a Tumour Marker in Carcinoma Oesophagus
Worldwide, carcinoma of the oesophagus is the sixth leading reason for deaths due to malignancy. MicroRNAs (MiRs) are a cluster of small non-coding...
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MicroRNA-92a-3p Inhibits Cell Proliferation and Invasion by Regulating the Transcription Factor 21/Steroidogenic Factor 1 Axis in Endometriosis
Endometriosis (EMS) is an estrogen-dependent disease. However, little is known about the regulation of estrogen, a potential therapeutic target, in...
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Inhibition of germinal vesicle breakdown using IBMX increases microRNA-21 in the porcine oocyte
BackgroundGerminal vesicle breakdown (GVBD) occurs during oocyte meiotic maturation, a period when transcriptional processes are virtually inactive....
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Cell-free microRNA-21: biomarker for intracranial aneurysm rupture
BackgroundDeregulation of miRNA-21 expression has been reported to be associated with vascular smooth muscle behavior and cytoskeletal stability....
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MicroRNA-21-5p participates in IgA nephropathy by driving T helper cell polarization
BackgroundPrevious studies have revealed abnormal lymphocyte subsets in IgA nephropathy (IgAN). Some microRNAs have been reported to influence T...
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Inhibition of microRNA-21-5p reduces keloid fibroblast autophagy and migration by targeting PTEN after electron beam irradiation
Electron beam (EB) irradiation is useful to reduce the recurrence of keloids; however, the underlying mechanism remains unknown. MicroRNA-21...
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Searching for airways biomarkers useful to identify progressive pulmonary fibrosis
BackgroundIdiopathic pulmonary fibrosis (IPF) is a chronic and progressive disorder with unknown etiology. To date, the identification of new...
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Pleiotropic microRNA-21 in pulmonary remodeling: novel insights for molecular mechanism and present advancements
MicroRNA-21 (miR-21), probably one of the most studied miRNAs to date, is found pleiotropic in various biological events. Its emerging role in...
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Assessment of Serum MicroRNA-21 Gene Expression for Diagnosis and Prognosis of Colorectal Cancer
BackgroundMicroRNAs (miRNAs) are small, non-coding RNAs that are involved in carcinogenesis through posttranscriptional gene regulatory activity. The...
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Exploring research progress in studying serum exosomal miRNA-21 as a molecular diagnostic marker for breast cancer
Breast cancer is one of the most prevalent malignancies affecting women globally and poses a significant public health challenge. Early clinical...