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Dear Editor,
We would like to share ideas on “Estimation of Serum MicroRNA 21 as a Tumour Marker in Carcinoma Oesophagus [1]”. Soong et al. concluded that “MiR 21 levels can be used as a novel marker for assessing disease severity in carcinoma oesophagus [1]”. We agree that MicroRNA 21 might be a useful biomarker. Indeed, several MicroRNAs are proposed for usefulness for using as biomarker in cancer [2]. For oesophageal cancer, another possible mRNA biomarker is 331-3p [3]. Regarding the present report on using MiR21, it should note for possible confounding conditions. MiR21 might also be elevated in other medical conditions. Examples are diabetes and cardiac disorders, which are common clinical problems [4, 5]. Further studies to control and assess possible confounding effects from those medical conditions are interesting.
References
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Liu F, Tian T, **a LL, Ding Y, Cormier RT, He Y (2017) Circulating miRNAs as novel potential biomarkers for esophageal squamous cell carcinoma diagnosis: a meta-analysis updateDis Esophagus 30(2):1–9
Gu J, Zhang J, Zheng L, Ajani JA, Wu X, Ye Y (2018) Serum miR-331-3p predicts tumor recurrence in esophageal adenocarcinoma. Sci Rep 8(1):14006
** ZQ (2021) MicroRNA targets and biomarker validation for diabetes-associated cardiac fibrosis. Pharmacol Res 14(174):105941
Milluzzo A, Maugeri A, Barchitta M, Sciacca L, Agodi A (2021) Epigenetic mechanisms in type 2 diabetes retinopathy: a systematic review. Int J Mol Sci 22(19):10502
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Mungmunpuntipantip, R., Wiwanitkit, V. Serum MicroRNA 21 and Tumour Marker in Oesophagus Cancer: Correspondence. Indian J Surg Oncol 13, 628 (2022). https://doi.org/10.1007/s13193-022-01536-4
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DOI: https://doi.org/10.1007/s13193-022-01536-4