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Mast Cell–Targeting Therapies in Mast Cell Activation Syndromes
Purpose of ReviewProvide an overview of the expanding landscape of mast cell (MC)–targeting treatments in mast cell activation syndromes (MCAS).
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Acute mast cell leukemia without KIT D816V mutation and lack of CD2 and CD25—a case report of rare entity
Systemic mastocytosis (SM) is a rare hematological neoplasm caused by the excessive proliferation of pathological mast cells that accumulate in the...
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Mast cell density in Merkel cell carcinoma and its correlation with prognostic features and MCPyV status: a pilot study
Merkel cell carcinoma (MCC) is a rare, highly aggressive, primitive neuroendocrine carcinoma of the skin, the origin of which is not yet fully...
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Mast cell deficiency prevents BCR::ABL1 induced splenomegaly and cytokine elevation in a CML mouse model
The persistence of leukemic stem cells (LSCs) represents a problem in the therapy of chronic myeloid leukemia (CML). Hence, it is of utmost...
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Predictors of Clonality and Underlying Mastocytosis in Mast Cell Activation Syndromes
Purpose of ReviewMast cell (MC) activation can present with a wide range of symptoms. The mechanisms that cause such activation are varied. One of...
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Reversible Elevation of Tryptase Over the Individual's Baseline: Why is It the Best Biomarker for Severe Systemic Mast Cell Activation and MCAS?
Purpose of ReviewMast cell (MC) activation syndromes (MCAS) are conditions defined by recurrent episodes of severe systemic anaphylaxis or similar...
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Mast cell sarcoma: clinicopathologic and molecular analysis of 10 new cases and review of literature
Mast cell sarcoma (MCS) is an exceedingly rare form of mastocytosis characterized by invasive malignant mast cell growth and metastatic potential....
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T cell-mediated tumor killing sensitivity gene signature-based prognostic score for acute myeloid leukemia
Background and ObjectiveAcute myeloid leukemia (AML) is an aggressive, heterogenous hematopoetic malignancies with poor long-term prognosis. T-cell...
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Impact of hemodilution on flow cytometry based measurable residual disease assessment in acute myeloid leukemia
Measurable residual disease (MRD) measured in the bone marrow (BM) of acute myeloid leukemia (AML) patients after induction chemotherapy is an...
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Clinical significance of total nucleated cell count in bone marrow of patients with acute lymphoblastic leukemia who underwent allogeneic hematopoietic stem cell transplantation
The clinical implications of recipient bone marrow nucleated cell count (NCC) prior to allogeneic hematopoietic stem cell transplantation (allo-HSCT)...
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Health-related quality of life and health literacy in patients with systemic mastocytosis and mast cell activation syndrome
BackgroundSystemic mastocytosis is a rare genetic disease characterized by aberrant proliferation and/or activation of mast cells, resulting in...
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Nuclear factor I-C overexpression promotes monocytic development and cell survival in acute myeloid leukemia
Nuclear factor I-C (NFIC) belongs to a family of NFI transcription factors that binds to DNA through CAATT-boxes and are involved in cellular...
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Mast cell leukemia with t(8;21) and t(12;13): can we classify it as acute mast cell leukemia?
We report the case of a 69-year-old man who presented acute leukemia with circulating blasts and numerous atypical mast cells in peripheral blood....
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Allogeneic Hematopoietic Cell Transplantation in Advanced Systemic Mastocytosis: A retrospective analysis of the DRST and GREM registries
We identified 71 patients with AdvSM (aggressive SM [ASM], SM with an associated hematologic neoplasm [SM-AHN, e.g., acute myeloid leukemia, SM-AML],...
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CSRP1 gene: a potential novel prognostic marker in acute myeloid leukemia with implications for immune response
BackgroundAcute myeloid leukemia, constituting a majority of leukemias, grapples with a 24% 5-year survival rate. Recent strides in research have...
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Overcoming anti-PD-1/PD-L1 immune checkpoint blockade resistance: the role of macrophage, neutrophils and mast cells in the tumor microenvironment
In recent years, the anti-PD-1/PD-L1 blockade has become a game changer in cancer treatment following the unprecedented response rate. Regardless of...
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Identification and analysis of methylation signature genes and association with immune infiltration in pediatric acute myeloid leukemia
BackgroundAcute myeloid leukemia (AML) is a common leukemia with low cure rate and poor prognosis among pediatric patients. The regulation of AML...
