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POEMS syndrome with undetectable M-protein: a case report and literature review
BackgroundPolyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes (POEMS) syndrome is a rare plasma cell (PC) neoplasm with...
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Role of protein tyrosine phosphatase receptor type M in epithelial ovarian cancer progression
BackgroundEpithelial ovarian cancer (EOC) is often diagnosed at advanced stages with low survival rates. Protein tyrosine phosphatase receptor type M...
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m6A binding protein YTHDF2 in cancer
YT521-B homology domain family member 2 (YTHDF2) is an N 6 -methyladenosine (m 6 A)-binding protein that was originally found to regulate the stability...
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A case of crystalglobulin-induced nephropathy wherein M protein was identified by mass spectrometry and immunoglobulin G subclass staining
Crystalglobulin-induced nephropathy is a rare disease that causes the deposition of crystallized monoclonal immunoglobulins into the glomerular...
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Establishment of a peptide-based enzyme-linked immunosorbent assay for detecting antibodies against PRRSV M protein
BackgroundPorcine reproductive and respiratory syndrome (PRRS) is one of the most economically devastating diseases affecting the swine industry...
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Successful treatment with daratumumab, lenalidomide, and dexamethasone therapy followed by autologous stem cell transplantation for newly diagnosed polyneuropathy, organomegaly, endocrinopathy, M-protein, skin changes syndrome: a case report
BackgroundTransplant-eligible patients with polyneuropathy, organomegaly, endocrinopathy, M-protein, skin changes syndrome are treated with induction...
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Comparative efficacy of micro-erythrocyte sedimentation rate (m-ESR) and C-reactive protein (CRP) as a neonatal septic screening marker—a single-center, retrospective observational study
BackgroundNeonatal sepsis is a clinical syndrome characterized by signs and symptoms of infection with or without accompanying bacteremia in neonatal...
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The m6A reading protein YTHDF3 potentiates tumorigenicity of cancer stem-like cells in ocular melanoma through facilitating CTNNB1 translation
N 6 -methyladenosine (m 6 A) is the most universal internal RNA modification on messenger RNAs and regulates the fate and functions of m 6 A-modified...
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Reproductive Functions of the Mitochondrial Progesterone Receptor (PR-M)
Classic transcriptional regulation by progesterone via the nuclear progesterone receptors A and B (PR-A, PR-B) has been recognized for decades. Less...
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SARS-CoV-2 nucleocapsid protein, rather than spike protein, triggers a cytokine storm originating from lung epithelial cells in patients with COVID-19
PurposeThe aim of this study was to elucidate the factors associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that may...
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IRAK-M has effects in regulation of lung epithelial inflammation
BackgroundEpithelial barrier is important for asthma development by sha** immune responses. Airway expressing-IL-1 receptor-associated kinase...
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Programmed cell death 11 modulates but not entirely relies on p53-HDM2 loop to facilitate G2/M transition in colorectal cancer cells
We previously described a nucleolar protein RSL1D1 but distributed throughout the nucleus in HCT116 colorectal cancer (CRC) cells to facilitate G1/S...
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Association between albumin–bilirubin grade and plasma trough concentrations of regorafenib and its metabolites M-2 and M-5 at steady-state in Japanese patients
The aim of the present study was to determine whether the trough plasma concentrations (C 0 ) of regorafenib and its metabolites, the N-oxide...
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The Association between Dietary Protein Diversity and Protein Patterns with Frailty in Older Chinese Adults: A Population-Based Cohort Study
ObjectivesFrailty is a pervasive condition among older people worldwide. Despite the association between higher protein intake and lower frailty risk...
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N1-methylation of adenosine (m1A) in ND5 mRNA leads to complex I dysfunction in Alzheimer’s disease
One mechanism of particular interest to regulate mRNA fate post-transcriptionally is mRNA modification. Especially the extent of m 1 A mRNA methylation...
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DRAIC mediates hnRNPA2B1 stability and m6A-modified IGF1R instability to inhibit tumor progression
Type 1 insulin-like growth factor receptor (IGF1R) plays an important role in cancer, however, posttranscriptional regulation such as N 6 -methyladenosi...
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The roles and implications of RNA m6A modification in cancer
N 6 -Methyladenosine (m 6 A), the most prevalent internal modification in eukaryotic mRNA, has been extensively and increasingly studied over the past...
