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Alpha-lipoic acid induced insulin autoimmune antibody syndrome
BackgroundInsulin autoimmune antibody syndrome is an uncommon cause of hypoglycemia in non-diabetic individuals. We report a case of alpha-lipoic...
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To observe the clinical effect of lipoic acid combined with continuous positive airway pressure ventilation in treating obstructive sleep apnea–hypopnea syndrome and its effect on peripheral blood γ-aminobutyric acid and melatonin levels
BackgroundObstructive sleep apnea–hypopnea syndrome (OSAHS) is a common respiratory disease with potential lethality. At present, the commonly used...
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Coenzyme Q10 + alpha lipoic acid for chronic COVID syndrome
Chronic COVID syndrome is characterized by chronic fatigue, myalgia, depression and sleep disturbances, similar to chronic fatigue syndrome (CFS) and...
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Alpha-lipoic acid induced apoptosis of PC3 prostate cancer cells through an alteration on mitochondrial membrane depolarization and MMP-9 mRNA expression
Cancer has become an important cause of mortality and morbidity in the world. Over the past decades, biomedical research revealed insights into the...
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Effect of oral alpha-lipoic acid (ALA) on sperm parameters: a systematic review and meta-analysis
BackgroundMale fertility has gradually become a worldwide problem with limitations in the treatment. Alpha-lipoic acid, has been applied to improve...
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Outcomes of dietary alpha-lipoic acid on testicular vascularization, steroid hormones, and seminal quality in aged Baladi bucks
BackgroundSenescence is accompanied by a progressive decrease in male reproductive performance, mainly due to oxidative stress and endothelial...
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Myocardial complications induced by hypothyroidism in rats: effects of metformin and alpha lipoic acid
Hypothyroidism has adverse effects on heart metabolism and functions including reduced heart rate, cardiac output and cardiac contractility. The...
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Alpha-lipoic acid supplementation corrects pathological alterations in cellular models of pantothenate kinase-associated neurodegeneration with residual PANK2 expression levels
BackgroundNeurodegeneration with brain iron accumulation (NBIA) disorders are a group of neurodegenerative diseases that have in common the...
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Role of alpha-lipoic acid in counteracting paclitaxel- and doxorubicin-induced toxicities: a randomized controlled trial in breast cancer patients
Background and objectivePaclitaxel and doxorubicin are associated with neurotoxicity and cardiotoxicity respectively. This study aimed at...
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Metformin and alpha lipoic acid ameliorate hypothyroidism and its complications in adult male rats
ObjectiveThe current study evaluates the effect of metformin (MET) and /or alpha lipoic acid (ALA) on hypothyroidism and its adverse effects on the...
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Effects of alpha-lipoic acid on sperm quality in patients with varicocele-related male infertility: study protocol for a randomized controlled clinical trial
BackgroundVaricocele is a high incidence and is considered to be the most common and correctable cause of male infertility. Oxidative stress (OS)...
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Alpha-lipoic acid activates AMPK to protect against oxidative stress and apoptosis in rats with diabetic peripheral neuropathy
PurposeTo investigate the AMPK pathway–mediated effect of alpha-lipoic acid (ALA) on the dorsal root ganglia (DRGs) of rats with diabetic peripheral...
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Effects of valsartan combined with α-lipoic acid on renal function in patients with diabetic nephropathy: a systematic review and meta-analysis
BackgroundDiabetic nephropathy (DN) is one of the most serious microvascular complications of diabetes, valsartan and α-lipoic acid alone or in...
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Targeting hepatic sulfane sulfur/hydrogen sulfide signaling pathway with α-lipoic acid to prevent diabetes-induced liver injury via upregulating hepatic CSE/3-MST expression
BackgroundDiabetes-induced liver injury is a complication of diabetes mellitus of which there are no approved drugs for effective treatment or...
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Alpha-lipoic acid administration affects psychological status and markers of inflammation and oxidative damage in patients with type 2 diabetes and coronary heart disease
BackgroundThis investigation was performed to assess the effects of alpha-lipoic acid (ALA) supplementation on psychological status and markers of...
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Alpha-lipoic acid potentiates the anti-arrhythmic effects of ischemic postconditioning in the setting of cardiac ischemia/reperfusion injury in diabetic rats
BackgroundPrevention of lethal ventricular arrhythmias induced by myocardial ischemia/reperfusion (I/R) in diabetic patients is the major goal of...
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Maternal supplementation of α-lipoic acid attenuates prenatal cytarabine exposure-induced oxidative stress, steroidogenesis suppression and testicular damage in F1 male rat fetus
BackgroundCytarabine (Ara-C) is an anticancer drug, which is considered as the mainstay in the treatment of hematological malignancies, known to...
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Alpha-lipoic acid-role in improving both reserpine toxicity and paroxetine treatment in the cerebral cortex of albino rats; histological, ultrastructural, immunohistohemical and biochemical studies
BackgroundReserpine is a monoamine depletory drug cause oxidative damage and used to induce depression-like features in rodent model. Paroxetine is...
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Aberrant expression of cuproptosis‑related gene LIPT1 is associated with metabolic dysregulation of fatty acid and prognosis in hepatocellular carcinoma
PurposeLipoyltransferase 1 (LIPT1) has been recently identified as a cuproptosis‑related gene. As a key enzyme of lipoic acid metabolism, LIPT1 has...
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The effect of a-Lipoic acid (ALA) on oxidative stress, inflammation, and apoptosis in high glucose–induced human corneal epithelial cells
PurposeOxidative stress and inflammation had been proved to play important role in the progression of diabetic keratopathy (DK). The excessive...
