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Triangulating evidence from observational and Mendelian randomization studies of ketone bodies for cognitive performance
BackgroundKetone bodies (KBs) are an alternative energy supply for brain functions when glucose is limited. The most abundant ketone metabolite,...
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Ketone bodies: from enemy to friend and guardian angel
AbstractDuring starvation, fasting, or a diet containing little digestible carbohydrates, the circulating insulin levels are decreased. This promotes...
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Innovations and applications of ketone body monitoring in diabetes care
Ketone bodies, comprising β-hydroxybutyric acid (BHB), acetoacetate (AcAc), and acetone, play a vital role as essential energy substrates. In...
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Effect of empagliflozin on ketone bodies in patients with stable chronic heart failure
BackgroundRecent studies indicated that sodium glucose cotransporter (SGLT)2 inhibition increases levels of ketone bodies in the blood in patients...
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Prognostic role of urinary ketone body in patients with sepsis-associated encephalopathy without hepatic failure: a retrospective cohort study
Sepsis-associated encephalopathy (SAE) is defined as a dysfunction of the central nervous system experienced during sepsis with variable clinical...
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Relationships Between Changes in Serum Ketone Body Levels and Metabolic Effects in Patients with Severe Obesity Who Underwent Laparoscopic Sleeve Gastrectomy
BackgroundSerum ketone bodies increase due to dynamic changes in the lipid metabolisms of patients undergoing bariatric surgery. However, there have...
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Sodium butyrate activates HMGCS2 to promote ketone body production through SIRT5-mediated desuccinylation
Ketone bodies have beneficial metabolic activities, and the induction of plasma ketone bodies is a health promotion strategy. Dietary supplementation...
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Exogenous Ketone Supplements in Athletic Contexts: Past, Present, and Future
The ketone bodies acetoacetate (AcAc) and β-hydroxybutyrate (βHB) have pleiotropic effects in multiple organs including brain, heart, and skeletal...
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Serum ketone body measurement in patients with diabetic ketoacidosis
BackgroundDiabetic ketoacidosis (DKA) is a critical manifestation in patients with diabetes mellitus. DKA has been conventionally diagnosed by the...
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Ketogenic diet in refractory migraine: possible efficacy and role of ketone bodies—a pilot experience
IntroductionRefractory migraine is a particularly disabling form of chronic migraine, unresponsive to multiple prophylactic strategies. Ketogenic...
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Ketone body levels and its associations with cardiac markers following an acute myocardial infarction: a post hoc analysis of the EMMY trial
BackgroundSodium-glucose co-transporter 2 inhibitors (SGLT2i) have been suggested to exert cardioprotective effects in patients with heart failure,...
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Interference of ketone bodies on laboratory creatinine measurement in children with DKA: a call for change in testing practices
BackgroundThe presence of ketone bodies (KBs) can interfere with creatinine (Cr) measurement in both enzymatic and Jaffe methods. Since a high...
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The effectiveness of blood glucose and blood ketone measurement in identifying significant acidosis in diabetic ketoacidosis patients
BackgroundPatients with diabetic ketoacidosis (DKA), a potentially fatal complication of type 1 diabetes, have hyperglycemia, ketonemia and metabolic...
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Potential Clinical Applications for Continuous Ketone Monitoring in the Hospitalized Patient with Diabetes
Purpose of ReviewIn this review, the authors discuss potential clinical applications for continuous ketone monitoring (CKM) in a broad continuum of...
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Ketone body 3-hydroxybutyrate elevates cardiac output through peripheral vasorelaxation and enhanced cardiac contractility
The ketone body 3-hydroxybutyrate (3-OHB) increases cardiac output and myocardial perfusion without affecting blood pressure in humans, but the...
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Effects of intermittently scanned continuous glucose monitoring on blood glucose control and the production of urinary ketone bodies in pregestational diabetes mellitus
ObjectiveTo investigate the effects of intermittently scanned continuous glucose monitoring (isCGM) on blood glucose control, clinical value of blood...
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Ketone supplementation abolished isoflurane anesthesia-induced elevation in blood glucose level and increased recovery time from anesthesia in Wistar Albino Glaxo Rijswijk rats
BackgroundIt has been suggested that administration of exogenous ketone supplements (EKSs) not only increases blood ketone body levels but also...
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Ketone Ester Effects on Biomarkers of Brain Metabolism and Cognitive Performance in Cognitively Intact Adults ≥ 55 Years Old. A Study Protocol for a Double-Blinded Randomized Controlled Clinical Trial
BackgroundKetone bodies have been proposed as an “energy rescue” for the Alzheimer’s disease (AD) brain, which underutilizes glucose. Prior research...
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Ketone body β-hydroxybutyrate ameliorates colitis by promoting M2 macrophage polarization through the STAT6-dependent signaling pathway
BackgroundKetone body β-hydroxybutyrate (BHB) has received more and more attentions, because it possesses a lot of beneficial, life-preserving...
