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Innovations and applications of ketone body monitoring in diabetes care
Ketone bodies, comprising β-hydroxybutyric acid (BHB), acetoacetate (AcAc), and acetone, play a vital role as essential energy substrates. In...
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Prognostic role of urinary ketone body in patients with sepsis-associated encephalopathy without hepatic failure: a retrospective cohort study
Sepsis-associated encephalopathy (SAE) is defined as a dysfunction of the central nervous system experienced during sepsis with variable clinical...
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Sodium butyrate activates HMGCS2 to promote ketone body production through SIRT5-mediated desuccinylation
Ketone bodies have beneficial metabolic activities, and the induction of plasma ketone bodies is a health promotion strategy. Dietary supplementation...
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Relationships Between Changes in Serum Ketone Body Levels and Metabolic Effects in Patients with Severe Obesity Who Underwent Laparoscopic Sleeve Gastrectomy
BackgroundSerum ketone bodies increase due to dynamic changes in the lipid metabolisms of patients undergoing bariatric surgery. However, there have...
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Exogenous Ketone Supplements in Athletic Contexts: Past, Present, and Future
The ketone bodies acetoacetate (AcAc) and β-hydroxybutyrate (βHB) have pleiotropic effects in multiple organs including brain, heart, and skeletal...
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Serum ketone body measurement in patients with diabetic ketoacidosis
BackgroundDiabetic ketoacidosis (DKA) is a critical manifestation in patients with diabetes mellitus. DKA has been conventionally diagnosed by the...
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The effectiveness of blood glucose and blood ketone measurement in identifying significant acidosis in diabetic ketoacidosis patients
BackgroundPatients with diabetic ketoacidosis (DKA), a potentially fatal complication of type 1 diabetes, have hyperglycemia, ketonemia and metabolic...
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Triangulating evidence from observational and Mendelian randomization studies of ketone bodies for cognitive performance
BackgroundKetone bodies (KBs) are an alternative energy supply for brain functions when glucose is limited. The most abundant ketone metabolite,...
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Potential Clinical Applications for Continuous Ketone Monitoring in the Hospitalized Patient with Diabetes
Purpose of ReviewIn this review, the authors discuss potential clinical applications for continuous ketone monitoring (CKM) in a broad continuum of...
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Ketone body levels and its associations with cardiac markers following an acute myocardial infarction: a post hoc analysis of the EMMY trial
BackgroundSodium-glucose co-transporter 2 inhibitors (SGLT2i) have been suggested to exert cardioprotective effects in patients with heart failure,...
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Ketone body 3-hydroxybutyrate elevates cardiac output through peripheral vasorelaxation and enhanced cardiac contractility
The ketone body 3-hydroxybutyrate (3-OHB) increases cardiac output and myocardial perfusion without affecting blood pressure in humans, but the...
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Ketone bodies: from enemy to friend and guardian angel
AbstractDuring starvation, fasting, or a diet containing little digestible carbohydrates, the circulating insulin levels are decreased. This promotes...
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Ketone supplementation abolished isoflurane anesthesia-induced elevation in blood glucose level and increased recovery time from anesthesia in Wistar Albino Glaxo Rijswijk rats
BackgroundIt has been suggested that administration of exogenous ketone supplements (EKSs) not only increases blood ketone body levels but also...
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A ketone monoester drink reduces postprandial blood glucose concentrations in adults with type 2 diabetes: a randomised controlled trial
Aims/hypothesisThe aim of the present study was to conduct a randomised, placebo-controlled, double-blind, crossover trial to determine whether...
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Mechanical failure of distal femur mega prosthesis due to polyaryl-ether-ether-ketone (PEEK) hinge component
BackgroundPolyaryl-ether-ether-ketone (PEEK) has gained popularity as a substrate for orthopaedic hardware due to its desirable properties such as...
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Intravenous and oral whole body ketone dosimetry, biodistribution, metabolite correction and kinetics studied by (R)-[1-11C]β-hydroxybutyrate ([11C]OHB) PET in healthy humans
BackgroundKetones are increasingly recognized as an important and possibly oxygen sparing source of energy in vital organs such as the heart, the...
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Ketogenic diet in refractory migraine: possible efficacy and role of ketone bodies—a pilot experience
IntroductionRefractory migraine is a particularly disabling form of chronic migraine, unresponsive to multiple prophylactic strategies. Ketogenic...
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Effect of empagliflozin on ketone bodies in patients with stable chronic heart failure
BackgroundRecent studies indicated that sodium glucose cotransporter (SGLT)2 inhibition increases levels of ketone bodies in the blood in patients...
