Search
Search Results
-
Single-cell sequencing of tumour infiltrating T cells efficiently identifies tumour-specific T cell receptors based on the T cell activation score
Adoptively transferred T cell receptor-engineered T cells are a promising cancer treatment strategy, and the identification of tumour-specific TCRs...
-
Egr2 and 3 maintain anti-tumour responses of exhausted tumour infiltrating CD8 + T cells
Although T cells can develop into an exhausted state in the tumour microenvironment, tumour infiltrating T cells (TILs) are important to control...
-
Colorectal cancer cells secreting DKK4 transform fibroblasts to promote tumour metastasis
Wnt/β-catenin signalling is aberrantly activated in most colorectal cancer (CRC) and is one key driver involved in the initiation and progression of...
-
Circulating tumour cells for early detection of clinically relevant cancer
Given that cancer mortality is usually a result of late diagnosis, efforts in the field of early detection are paramount to reducing cancer-related...
-
The Simultaneous Presence of Isolated Tumour Cells and Bone Marrow Micrometastases in Stage I and II Colon Cancer—Challenging the Theory of a Chronological Pathway of Tumour Cell Dissemination
BackgroundAccording to the common tenet, tumour progression is a chronological process starting with lymphatic invasion. In this respect, the meaning...
-
XFab-α4-1BB/CD40L fusion protein activates dendritic cells, improves expansion of antigen-specific T cells, and exhibits antitumour efficacy in multiple solid tumour models
BackgroundAdditional immunotherapies are still warranted for non-responders to checkpoint inhibitors with refractory or relapsing cancers, especially...
-
Cancer metastasis chemoprevention prevents circulating tumour cells from germination
The war against cancer traces back to the signature event half-a-century ago when the US National Cancer Act was signed into law. The cancer crusade...
-
Brown Tumour of the Premaxilla
Brown tumours of the head and neck region are rare. They occur in the setting of increased secretion of parathormone (PTH) from hyper functioning...
-
Stromal nicotinamide N-methyltransferase orchestrates the crosstalk between fibroblasts and tumour cells in oral squamous cell carcinoma: evidence from patient-derived assembled organoids
Nicotinamide N -methyltransferase (NNMT) has been reported to be linked to methylation reprogramming in cancer cells. However, the role of NNMT in the...
-
B cells and tertiary lymphoid structures as determinants of tumour immune contexture and clinical outcome
B cells are a major component of the tumour microenvironment, where they are predominantly associated with tertiary lymphoid structures (TLS). In...
-
Melanotic Neuroectodermal Tumour of Infancy
Melanotic neuroectodermal tumour of infancy (MNTI) is a locally aggressive neoplasm of neural crest origin. It is primarily a paediatric tumour, and...
-
Zebrafish tumour xenograft models: a prognostic approach to epithelial ovarian cancer
Epithelial ovarian cancer (EOC) is the gynaecological malignancy with highest mortality. Although adjuvant treatment with carboplatin and paclitaxel...
-
Hallmark discoveries in the biology of Wilms tumour
The modern study of Wilms tumour was prompted nearly 50 years ago, when Alfred Knudson proposed the ‘two-hit’ model of tumour development. Since...
-
EZH2 endorses cell plasticity to non-small cell lung cancer cells facilitating mesenchymal to epithelial transition and tumour colonization
Reversible transition between the epithelial and mesenchymal states are key aspects of carcinoma cell dissemination and the metastatic disease, and...
-
Interleukin 33 supports squamous cell carcinoma growth via a dual effect on tumour proliferation, migration and invasion, and T cell activation
Interleukin (IL)-33 is an important cytokine in the tumour microenvironment; it is known to promote the growth and metastasis of solid cancers, such...
-
γδ T cells in human colon adenocarcinomas comprise mainly Vδ1, Vδ2, and Vδ3 cells with distinct phenotype and function
Γδ T cell infiltration into tumours usually correlates with improved patient outcome, but both tumour-promoting and tumoricidal effects of γδ T cells...
-
Tumour cell-activated platelets modulate the immunological activity of CD4+, CD8+, and NK cells, which is efficiently antagonized by heparin
Platelets, key players in haemostasis, are progressively investigated with respect to their role in immunity and inflammation. Although the platelet...
-
Leukocyte-associated immunoglobulin-like receptor-1 blockade in combination with programmed death-ligand 1 targeting therapy mediates increased tumour control in mice
Collagen expression and structure in the tumour microenvironment are associated with tumour development and therapy response. Leukocyte-associated...
-
Dominant-negative transforming growth factor-β receptor-armoured mesothelin-targeted chimeric antigen receptor T cells slow tumour growth in a mouse model of ovarian cancer
Ovarian cancer is a major cause of death among all gynaecological cancers. Although surgery, chemotherapy and targeted therapy have yielded...
-
Giant cell-rich solitary fibrous tumour of the urinary bladder: case report of an unusual histological variant and literature review
BackgroundGiant cell-rich solitary fibrous tumour (GCR-SFT), previously referred to as giant cell angiofibroma, is an uncommon soft tissue tumour...
