Search
Search Results
-
The role of IGF/IGF-1R signaling in the regulation of cancer stem cells
Cancer stem cells (CSCs) are a group of tumor cells with high tumorigenic ability and self-renewal potential similar to those of normal stem...
-
IGF-1’s protective effect on OSAS rats’ learning and memory
PurposePatients with obstructive sleep apnea syndrome (OSAS) frequently experience cognitive dysfunction, which may be connected to chronic...
-
An exploratory study of clinical factors associated with IGF-1 and IGFBP-3 in preterm infants
BackgroundDespite advances in parenteral nutrition, postnatal growth failure in very low birthweight (VLBW) preterm infants is common and associated...
-
Muscle hypertrophy training does not suppress the GH/IGF axis in young adult males
PurposeThis study aimed to analyze the expression of the IGF type-1 receptor gene (IGF-1r) and IGF-I, GH, testosterone, and IGFBP-3 concentrations in...
-
IGF-1 is positively associated with BMI in patients with acromegaly
PurposeAcromegaly is a disorder characterized by IGF-1 excess due to autonomous GH secretion. In individuals without acromegaly, IGF-1 is not only...
-
Association of an impaired GH-IGF-I axis with cardiac wasting in patients with advanced cancer
BackgroundGrowth hormone (GH) resistance is characterized by high GH levels but low levels of insulin-like growth factor-I (IGF-I) and growth hormone...
-
Very low serum IGF-1 levels are associated with vertebral fractures in adult males with beta-thalassemia major
PurposePatients with beta-thalassemia major (BTM) often develop several endocrine disorders due to chronic iron overload. They are also prone to...
-
Recombinant IGF-1/BP3 protects against intestinal injury in a neonatal mouse NEC model
BackgroundRecombinant human IGF-1/binding protein-3 (rhIGF-1/BP3) is currently being tested in phase II clinical trials in premature infants to...
-
Paradoxical effect of dopamine-agonists on IGF-1 in patients with prolactinoma: the role of weight
PurposeAn increase of IGF-1 has been reported during therapy with dopamine agonists (DA) for prolactinomas; in such cases a correct diagnosis is...
-
Expression of Salivary and Serum IGF-1 and IGFBP-3 in Individuals With Diabetes and Oral Cancer
AimTo evaluate the expression of salivary and serum Insulin-like growth factor-1 (IGF-1) and Insulin-like growth factor binding protein-3 (IGFBP-3)...
-
Association between metabolic syndrome, insulin resistance, and IGF-1 in breast cancer survivors of DIANA-5 study
PurposeCirculating insulin-like growth factor-1 (IGF-1) is positively associated with the risk of BC recurrence, and is more frequently dysregulated...
-
A novel role of IGFBP5 in the migration, invasion and spheroids formation induced by IGF-I and insulin in MCF-7 breast cancer cells
PurposeThe insulin-like growth factor (IGF) system includes IGF-I, IGF-II insulin and their membrane receptors. IGF system also includes a family of...
-
Inflammation induces stunting by lowering bone mass via GH/IGF-1 inhibition in very preterm infants
BackgroundSustained systemic inflammatory response (SIR) was associated with poor postnatal growth in very preterm infants (VPI). We hypothesize that...
-
The relationship between morning blood pressure surge and serum IGF-1 level in acromegaly patients with hypertension
ObjectiveHigh levels of insulin-like growth factor 1 (IGF-1) in patients with acromegaly cause structural and functional changes specific to the...
-
Activation of NFAT by HGF and IGF-1 via ARF6 and its effector ASAP1 promotes uveal melanoma metastasis
Preventing or effectively treating metastatic uveal melanoma (UM) is critical because it occurs in about half of patients and confers a very poor...
-
The somatotroph pituitary gland function in high-aged multimorbid hospitalized patients with IGF-I deficiency
PurposeIt is unclear whether the age-related decline in the somatotropic axis stems from a reduced growth hormone (GH) production in the pituitary...
-
Noncoding RNA actions through IGFs and IGF binding proteins in cancer
The insulin-like growth factors (IGFs) and their regulatory proteins—IGF receptors and binding proteins—are strongly implicated in cancer progression...
-
Correlation between serum IGF-1 and EGF levels and neuropsychiatric and cognitive in Parkinson’s disease patients
BackgroundInsulin-like growth factor 1 (IGF-1) and epidermal growth factor (EGF) exert neuroprotective effects in Parkinson’s disease (PD). To date,...
-
Inhibition of the epigenetically activated miR-483-5p/IGF-2 pathway results in rapid loss of meningioma tumor cell viability
PurposeMeningioma is the most common primary central nervous system tumor often causing serious complications, and presently no medical treatment is...
-
Mouse model of Graves’ orbitopathy induced by the immunization with TSHR A and IGF-1R α subunit gene
PurposeThe study aimed to establish a mouse model of Graves’ disease (GD) with Graves’ orbitopathy (GO; GD + GO) that can represent the clinical...
