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GFRA4 improves the neurogenic potential of enteric neural crest stem cells via hedgehog pathway
BackgroundHirschsprung disease (HSCR) is a congenital intestinal disease characterised by functional obstruction of the colon. Herein, we...
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Hedgehog pathway in sarcoma: from preclinical mechanism to clinical application
Sarcomas are a diverse group of malignant neoplasms of mesenchymal origin. They develop rarely, but due to poor prognosis, they are a challenging and...
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Ablative fractional laser treatment reduces hedgehog pathway gene expression in murine basal cell carcinomas
This study aimed to investigate the impact of ablative fractional laser (AFL) on hedgehog pathway gene expression in murine microscopic basal cell...
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PDLIM3 knockdown promotes ferroptosis in endometriosis progression via inducing Gli1 degradation and blocking Hedgehog signaling pathway
AimsCurrent evidence suggests that there is no completely effective method for endometriosis (EMS) without trauma due to diverse adverse effects....
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A Sonic Hedgehog Pathway Score to Predict the Outcome of Resected Non-Small Cell Lung Cancer Patients
BackgroundMutations and deregulations in components of the Hedgehog (Hh) pathway have been associated with cancer onset and tumor growth in different...
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Evaluation of the Tolerability of Hedgehog Pathway Inhibitors in the Treatment of Advanced Basal Cell Carcinoma: A Narrative Review of Treatment Strategies
Hedgehog pathway inhibitors (HHIs) have broadened the treatment options available for patients with advanced basal cell carcinoma (BCC) for whom...
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A clinicopathological exploration of Hedgehog signaling: implications in oral carcinogenesis
IntroductionHedgehog Signaling, a basic cancer stem cell pathway, plays a major role during the embryonic development, is known to play a quiescent...
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Usability of serum hedgehog signalling proteins as biomarkers in canine mammary carcinomas
BackgroundThe hedgehog signalling pathway has been implicated in tumourigenesis and progression of many tumour types. This pathway has recently...
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The crosstalk between long non-coding RNAs and the hedgehog signaling pathway in cancer
Hedgehog (Hh) is a conserved signaling pathway that is involved in embryo development as well as adult tissue maintenance and repair in invertebrates...
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CRP inhibits the osteoblastic differentiation of OPCs via the up-regulation of primary cilia and repression of the Hedgehog signaling pathway
Inflammation disrupts bone metabolism and leads to bone damage. C-reactive protein (CRP) is a typical inflammation marker. Although CRP measurement...
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TRIM37 interacts with EZH2 to epigenetically suppress PTCH1 and regulate stemness in glioma stem cells through sonic hedgehog pathway
BackgroundGlioma stem cells (GSCs), which are known for their therapy resistance, play a substantial role in treatment inefficacy for glioblastoma...
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GIMAP7 induces oxidative stress and apoptosis of ovarian granulosa cells in polycystic ovary syndrome by inhibiting sonic hedgehog signalling pathway
Polycystic ovary syndrome (PCOS) is a gynaecological endocrine disease. The objective of the present study was to investigate the role of GTPase...
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ABT-737 suppresses aberrant Hedgehog pathway and overcomes resistance to smoothened antagonists by blocking Gli
Abnormally activated Hedgehog (Hh) pathway has been linked to multiple types of cancers including medulloblastoma (MB). Current Hh-targeted drug...
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Hedgehog signaling in tissue homeostasis, cancers, and targeted therapies
The past decade has seen significant advances in our understanding of Hedgehog (HH) signaling pathway in various biological events. HH signaling...
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Ligand-dependent hedgehog signaling maintains an undifferentiated, malignant osteosarcoma phenotype
TP53 and RB1 loss-of-function mutations are common in osteosarcoma. During development, combined loss of TP53 and RB1 function leads to...
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Retraction Note to: Effect of RAB31 silencing on osteosarcoma cell proliferation and migration through the Hedgehog signaling pathway
The authors have retracted this article. After publication the authors discovered that they were unable to repeat their results. In this article the...
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Qualitative Patient Interviews to Characterize the Human Burden of Advanced Basal Cell Carcinoma Following Hedgehog Pathway Inhibitor Treatment
IntroductionEvidence of patients’ experiences of living with advanced basal cell carcinoma (aBCC) are limited, particularly after hedgehog pathway...
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P4HA2 hydroxylates SUFU to regulate the paracrine Hedgehog signaling and promote B-cell lymphoma progression
Aberrations in the Hedgehog (Hh) signaling pathway are significantly prevailed in various cancers, including B-cell lymphoma. A critical facet of Hh...
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Alopezie durch Chemotherapeutika, Hedgehog-Inhibitoren, zielgerichtete Antikörpertherapien und Immuncheckpointinhibitoren
BackgroundThe incidence and severity of alopecia vary mainly depending on the chemotherapeutic agent used or other drug groups. The pathogenetic...
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Activation of the hedgehog signaling pathway is associated with the promotion of cell proliferation and epithelial–mesenchymal transition in chronic rhinosinusitis with nasal polyps
PurposeTo investigate the pathogenesis of the hedgehog (Hh) signaling pathway activated by inflammation in the development of chronic rhinosinusitis...
