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Chemoprevention of pancreatic cancer by inhibition of glutathione-S transferase P1
Pancreatic cancer is among the most refractory malignancies with poor prognosis. Thus, preventive approaches, in addition to the development of novel...
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Expression Levels of Glutathione S-Transferase and Cytochrome P450 Isoenzymes in Nasal Polyp Tissue
Nasal polyps are benign sinonasal masses composed of eosinophils and extracellular edema. Pathogenesis of the polyp formation is unclear but several...
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Potential role of glutathione S-transferase P1 gene polymorphism and metabolic syndrome in lower urinary tract symptoms attributed to benign prostatic hyperplasia
ObjectiveThe aim of the study is to investigate the effects of glutathione S-transferase P1 ( GSTP1 ) gene polymorphism and metabolic syndrome (MS) on...
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Impact of gene polymorphism of glutathione S-transferase and ghrelin as a risk factor in Egyptian women with gestational diabetes mellitus
BackgroundGestational diabetes mellitus is the most common metabolic dysfunction that arises during pregnancy. GDM can lead to serious health...
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Glutathione S-transferase, catalase, and mitochondrial superoxide dismutase gene polymorphisms modulate redox potential in systemic lupus erythematosus patients from Manaus, Amazonas, Brazil
ObjectiveTo investigate the frequency of glutathione S-transferase (GST), catalase, and SOD2 genetic polymorphisms and their correlation with SLE.
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The morbidity and mortality of COVID-19 are correlated with the Ile105Val glutathione S-transferase P1 polymorphism
BackgroundOxidative stress is an important issue in coronavirus disease 2019 (COVID-19). Considering that glutathione S -transferase P1 ( GSTP1 ) is...
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Effect of oxidative stress-related genetic variants: “Explicating the role of reactive oxygen species influenced antioxidant gene polymorphism,” a risk stratification of type 2 diabetes mellitus-associated nephropathy: a systematic review
Type 2 diabetes mellitus is believed to be associated with microvascular complications which include diabetic retinopathy, nephropathy, and...
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Association of glutathione-S-transferase p1 gene promoter methylation and the incidence of prostate cancer: a systematic review and meta-analysis
ObjectiveSome studies have shown that the methylation status of the GSTP1 gene promoter is related to the incidence of prostate cancer, but this...
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ZNF384 transcriptionally activated MGST1 to confer TMZ resistance of glioma cells by negatively regulating ferroptosis
BackgroundDrug resistance is one of the major reasons of the poor prognosis and recurs frequently in glioma. Ferroptosis is considered to be a new...
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GSTO1 aggravates EGFR-TKIs resistance and tumor metastasis via deglutathionylation of NPM1 in lung adenocarcinoma
Despite significantly improved clinical outcomes in EGFR-mutant lung adenocarcinoma, all patients develop acquired resistance and malignancy on the...
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Links of platelet glutamate and glutathione metabolism with attenuated positive and negative symptoms in depressed patients at clinical high risk for psychosis
Aim of the study is to reveal clinical and biological correlations in patients with adolescent depression and attenuated psychotic symptoms. Activity...
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Relation between GSTP1 polymorphism and oxidative stress in patients with hepatocellular carcinoma
BackgroundGlutathione can reduce the oxidative stress by converting the unstable to stable molecules and its status in hepatocellular carcinoma (HCC)...
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Variations to plasma H2O2 levels and TAC in chronical medicated and treatment-resistant male schizophrenia patients: Correlations with psychopathology
Accumulating evidence suggests that imbalanced oxidative stress (OS) may contribute to the mechanism of schizophrenia. The aim of the present study...
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Association between ABCC2 polymorphism and hematological toxicity in patients with esophageal cancer receiving platinum plus 5-fluorouracil therapy
BackgroundPlatinum agents are taken up into cells by copper transporter (CTR) 1 (gene code: SLC31A1 ) and are excreted from cells by...
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Molecular and in silico analyses of SYN III gene variants in autism spectrum disorder
BackgroundDefects in neurotransmission and synaptogenesis are noteworthy in the pathogenesis of ASD. Synapsin III (SYN III) is defined as a synaptic...
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Anti-cancer potential of zerumbone in cancer and glioma: current trends and future perspectives
Plant-derived immunomodulators and antitumor factors have appealed lots of attention from natural product scientists for their efficiency and safety...
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Enhanced mosquitocidal efficacy of pyrethroid insecticides by nanometric emulsion preparation towards Culex pipiens larvae with biochemical and molecular docking studies
BackgroundThe growing threat of vector-borne diseases and environmental pollution with conventional pesticides has led to the search for...
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Arginine methylation of ALKBH5 by PRMT6 promotes breast tumorigenesis via LDHA-mediated glycolysis
ALKBH5 is a master regulator of N6-methyladenosine (m 6 A) modification, which plays a crucial role in many biological processes. Here, we show that...
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Liver-Metabolizing Genes and Their Relationship to the Performance of Elite Spanish Male Endurance Athletes; a Prospective Transversal Study
BackgroundThe genetic profile that is needed to define an endurance athlete has been studied during recent years. The main objective of this work is...
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Review of the Pharmacokinetics and Pharmacodynamics of Intravenous Busulfan in Paediatric Patients
We aimed to review the pharmacokinetics (PK) of intravenous busulfan in paediatric patients, identify covariate factors influencing exposure,...
