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TAAR1 dependent and independent actions of the potential antipsychotic and dual TAAR1/5-HT1A receptor agonist SEP-363856
SEP-363856 (SEP-856) is a novel antipsychotic under clinical development. It displays a unique pattern of receptor interaction, with only weak...
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LC-derived excitatory synaptic transmission to dorsal raphe serotonin neurons is inhibited by activation of alpha2-adrenergic receptors
In the central nervous system, noradrenaline transmission controls the degree to which we are awake, alert, and attentive. Aberrant noradrenaline...
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5-HT2A receptor dysregulation in a schizophrenia relevant mouse model of NMDA receptor hypofunction
Blockade of N -methyl-D-aspartate receptors (NMDAR) is known to augment cortical serotonin 2A receptors (5-HT2ARs), which is implicated in psychosis....
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Suppression of pyramidal neuron G protein-gated inwardly rectifying K+ channel signaling impairs prelimbic cortical function and underlies stress-induced deficits in cognitive flexibility in male, but not female, mice
Imbalance in prefrontal cortical (PFC) pyramidal neuron excitation:inhibition is thought to underlie symptomologies shared across stress-related...
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Leukocyte differential gene expression prognostic value for high versus low seizure frequency in temporal lobe epilepsy
BackgroundThis study was performed to test the hypothesis that systemic leukocyte gene expression has prognostic value differentiating low from high...
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Alcohol reverses the effects of KCNJ6 (GIRK2) noncoding variants on excitability of human glutamatergic neurons
Synonymous and noncoding single nucleotide polymorphisms (SNPs) in the KCNJ6 gene, encoding G protein-gated inwardly rectifying potassium channel...
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Identification of common core ion channel genes in epilepsy and Alzheimer’s disease
BackgroundAlthough available literature indicates that the incidence of dementia in the epilepsy population and the risk of seizures in the...
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Kardiogenetik in Deutschland – ein (Rück‑)Blick
The development of the cardiogenetics field in Germany has been increasing since the mid-1990s with many national contributions, some of...
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Therapeutic Innovations Against Opioid Tolerance and Addiction
Purpose of ReviewOpioids have a long history of use for relief of pain dating back thousands of years. Opium derived from the poppy plant is one of...
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Anxiolytic and antidepressants’ effect of Crataegus pinnatifida (Shan Zha): biochemical mechanisms
Depression and anxiety disorders are highly prevalent. Selective serotonin reuptake inhibitors (SSRIs) are the current first-line treatment for...
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The intersection of astrocytes and the endocannabinoid system in the lateral habenula: on the fast-track to novel rapid-acting antidepressants
Despite attaining significant advances toward better management of depressive disorders, we are still facing several setbacks. Develo**...
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Channelopathies in epilepsy: an overview of clinical presentations, pathogenic mechanisms, and therapeutic insights
Pathogenic variants in genes encoding ion channels are causal for various pediatric and adult neurological conditions. In particular, several...
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Using the drug repositioning approach to develop a novel therapy, tipepidine hibenzate sustained-release tablet (TS-141), for children and adolescents with attention-deficit/hyperactivity disorder
BackgroundAsverin® (tipepidine hibenzate) has been used as an antitussive for > 50 years in Japan. Studies revealed that tipepidine modulates...
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Mechanisms of neuromodulatory volume transmission
A wealth of neuromodulatory transmitters regulate synaptic circuits in the brain. Their mode of signaling, often called volume transmission, differs...
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Atrioventricular block after fingolimod resumption: a consequence of sphingosine-1-phosphate axis alteration due to COVID-19?
During the COVID-19 pandemic, concerns raised regarding the use of immunosuppressants in multiple sclerosis, even if current data do not support an...
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Das Orexinsystem als neuer Ansatz zur Besserung von Schlaf und Tagesaktivität – eine innovative Therapieoption zur Behandlung der chronischen Insomnie
Chronic insomnia is one of the most common sleep disorders. Its pharmacological therapy is limited to a few approved hypnotics.
The dual orexin...
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Heart rate variability and atrial fibrillation in the general population: a longitudinal and Mendelian randomization study
BackgroundSex differences and causality of the association between heart rate variability (HRV) and atrial fibrillation (AF) in the general...
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cAMP-mediated upregulation of HCN channels in VTA dopamine neurons promotes cocaine reinforcement
Chronic cocaine exposure induces enduring neuroadaptations that facilitate motivated drug taking. Hyperpolarization-activated cyclic nucleotide-gated...
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The role of orphan receptor GPR139 in neuropsychiatric behavior
Orphan G protein Coupled Receptors (GPCRs) present attractive targets both for understanding neuropsychiatric diseases and for development of novel...
