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Competing endogenous RNA network characterization of lymph node metastases in Leuran gastric cancer subtypes
Gastric cancer is a kind of tumor with strong heterogeneity. Long noncoding RNAs (lncRNAs) acting as competing endogenous RNAs (ceRNAs) play...
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Reconstruction and analysis of potential biomarkers for hypertrophic cardiomyopathy based on a competing endogenous RNA network
Hypertrophic cardiomyopathy (HCM) is a common heritable cardiomyopath. Although considerable effort has been made to understand the pathogenesis of...
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Construction of a circular RNA-based competing endogenous RNA network to screen biomarkers related to intervertebral disc degeneration
BackgroundIntervertebral disc degeneration (IDD) is a leading cause of disability with limited treatment strategies. A better understanding of the...
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Construction of lncRNA-related competing endogenous RNA network and identification of hub genes in recurrent implantation failure
BackgroundThe mechanism of recurrent implantation failure (RIF) is unclear at present and poor endometrial receptivity may be one of the leading...
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Competitive endogenous network of circRNA, lncRNA, and miRNA in osteosarcoma chemoresistance
Osteosarcoma is the most prevalent and fatal type of bone tumor. Despite advancements in the treatment of other cancers, overall survival rates for...
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Identification and comparison of novel circular RNAs with associated co-expression and competing endogenous RNA networks in postmenopausal osteoporosis
BackgroundCircular RNAs (circRNAs) are emerging as crucial regulators in various human diseases. So far, the expression profile and regulatory...
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Comprehensive identification of RNA transcripts and construction of RNA network in chronic obstructive pulmonary disease
BackgroundChronic obstructive pulmonary disease (COPD) is one of the world’s leading causes of death and a major chronic disease, highly prevalent in...
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Construction of a novel nomogram based on competing endogenous RNAs and tumor-infiltrating immune cells for prognosis prediction in elderly patients with colorectal cancer
Competitive endogenous RNAs (ceRNAs) and tumor-infiltrating immune cells play essential roles in colorectal cancer (CRC) tumorigenesis. However,...
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An RNA–RNA crosstalk network involving HMGB1 and RICTOR facilitates hepatocellular carcinoma tumorigenesis by promoting glutamine metabolism and impedes immunotherapy by PD-L1+ exosomes activity
Hepatocellular carcinoma (HCC) is the global leading cause of cancer-related deaths due to the deficiency of targets for precision therapy. A new...
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Analysis of differentially expressed genes in torn rotator cuff tendon tissues in diabetic patients through RNA-sequencing
BackgroundRotator cuff tears (RCT) is a common musculoskeletal disorder in the shoulder which cause pain and functional disability. Diabetes mellitus...
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Gene Profiling of Circular RNAs in Keloid-prone Individuals and ceRNA Network Construction During Wound Healing
AbstractEpigenetic alterations of non-coding RNA (ncRNA) are pivotal in the continuous activation and differentiation of fibroblasts in keloid....
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Construction of asthma related competing endogenous RNA network revealed novel long non-coding RNAs and potential new drugs
BackgroundAsthma is a heterogeneous disease characterized by chronic airway inflammation. Long non-coding RNA can act as competing endogenous RNA to...
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An integrated ceRNA network identifies miR-375 as an upregulated miRNA playing a tumor suppressive role in aggressive prostate cancer
Prostate cancer (PCa) remains a significant cause of morbidity and mortality among men worldwide. A number of genes have been implicated in prostate...
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LncRNA–mRNA expression profile and functional network of vascular dysfunction in septic rats
BackgroundWe used microarrays to analyse the changes in long non-coding RNAs (lncRNAs) and mRNAs in aorta tissue in model rats with...
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A novel ceRNA-immunoregulatory axis based on immune cell infiltration in ulcerative colitis-associated colorectal carcinoma by integrated weighted gene co-expression network analysis
BackgroundPatients with ulcerative colitis are at an increased risk of develo** colorectal cancer with a prolonged disease course. Many studies...
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Integrative analysis of the immune-related ceRNA network in fetal growth restriction based on weighted gene co-expression network analysis
PurposeImmune disorders lead to placental dysfunction and fetal growth restriction (FGR), but current research on the immune regulation mechanisms of...
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Construction of a circRNA-miRNA-mRNA network based on differentially co-expressed circular RNA in gastric cancer tissue and plasma by bioinformatics analysis
BackgroundIncreasing evidence implicates circular RNAs (circRNAs) have been involved in human cancer progression. However, the mechanism remains...
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PTGER3 and MMP-2 play potential roles in diabetic nephropathy via competing endogenous RNA mechanisms
BackgroundDiabetic nephropathy (DN) is a primary complication of diabetes mellitus (DM). The pathology of DN is still vague, and diagnostic accuracy...
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Genome-wide analysis of prognostic-related lncRNAs, miRNAs and mRNAs forming a competing endogenous RNA network in lung squamous cell carcinoma
PurposeAs a type of cancer with the highest morbidity and mortality, lung squamous cell carcinoma (LUSC) has a very poor prognosis. Long-non-coding...
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Non-coding RNA in the gut of the blood-feeding parasitic worm, Haemonchus contortus
The intestine of Haemonchus contortus is an essential tissue that has been indicated to be a major target for the prevention of haemonchosis caused...
