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Cholestatic Pruritus: Pathophysiology, Current Management Approach, and Emerging Therapies
Purpose of ReviewCholestatic pruritus refers to the sensation of itch experienced by patients with disease processes impairing bile flow. This...
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Cholestatic Pruritus Treatments in Primary Biliary Cholangitis and Primary Sclerosing Cholangitis: A Systematic Literature Review
Background and AimsWe conducted a systematic literature review to understand the evidence supporting treatment decisions for cholestatic pruritus...
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Development of the Patient- and Observer-Reported PRUCISION Instruments to Assess Pruritus and Sleep Disturbance in Pediatric Patients with Cholestatic Liver Diseases
IntroductionUnderstanding how patients experience their disease is a vital step in optimal disease management, and patient- and observer-reported...
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Title: Pruritus in the Elderly: Differential Diagnosis and Management
Purpose of ReviewPruritis is a highly prevalent symptom in older adults significantly impacting their quality of life. It can manifest in the...
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Cholestatic Itch: Our Current Understanding of Pathophysiology and Treatments
Hepatic pruritus is common in liver conditions, including cholestasis and nonalcoholic fatty liver disease. The pruritus can be severe enough to...
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Relationship between pruritus and sleep in participants with primary biliary cholangitis in the Phase 2b GLIMMER trial
BackgroundCholestatic pruritus and fatigue are debilitating conditions associated with primary biliary cholangitis (PBC) and can significantly impact...
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Pruritus: An Approach to Diagnosis and Management for the Inpatient Dermatologist
Purpose of ReviewThis review provides a framework to categorize causes of pruritus that may present in the inpatient dermatology setting and...
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Mechanisms of pruritus in cholestasis: understanding and treating the itch
Pruritus in cholestatic liver diseases can be a major burden and dramatically impair the quality of life of those affected. Here, we provide an...
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Empfohlene Diagnostik bei Pruritus auf primär unveränderter Haut
BackgroundChronic pruritus affecting primary non-lesional skin (CPNL) manifests as a common symptom across a spectrum of diseases spanning various...
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Approach and Work-Up for Medical Pruritus
Medical pruritus is characterized by itch secondary to systemic causes, which typically presents in the absence of primary skin lesions....
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Cholestatic liver injury secondary to over-the-counter cyproheptadine: case report and review of literature
BackgroundCyproheptadine is an easily available over-the-counter first-generation antihistaminic that is often used as an appetite stimulant....
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Clinical and genetic study of ABCB4 gene-related cholestatic liver disease in China: children and adults
BackgroundABCB4 gene-related cholestatic liver diseases have a wide spectrum of clinical and genetic variations. The correlation between genotype...
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An update on mechanisms of pruritus and their potential treatment in primary cutaneous T-cell lymphoma
Primary cutaneous T-cell lymphomas (CTCL), which include mycosis fungoides (MF) and Sézary syndrome (SS), are a group of lymphoproliferative...
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Pruritus Ani—Not an Itch that Can Be Ignored
Despite its prevalence and suspected neoplastic associations, pruritus ani is a condition that is both under-reported and under-researched. There is...
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Psychodermatology of Chronic Pruritus: An Overview of the Link Between Itch and Distress
Chronic pruritus (CP) is defined as an unpleasant sensation causing a desire to scratch and lasting > 6 weeks. It has a multifactorial etiology but...
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Cholestatic Liver Disease in a Child with KIF12 Mutation
Cholestatic liver diseases in children often have an underlying genetic defect. Genetic testing by next-generation sequencing has become a crucial...
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The effectiveness of sertraline in alleviating uremic pruritus in hemodialysis patients: a randomized clinical trial
IntroductionUremic pruritus (UP) is a common and distressing symptom in end stage renal disease (ESRD) patients. Many approaches have been tested to...
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Newer Approaches to the Management of Pruritus in Cholestatic Liver Disease
Purpose of ReviewChronic pruritus represents a burdensome symptom in cholestatic liver disease. This review recommends a stepwise therapeutic...
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Evaluation, management and future perspectives of anal pruritus: a narrative review
PurposeThe without a time limitation. Most recent search was performed on 1st June 2022.
ResultsThorough history and physical examination are very...
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Impact of Pruritus on Quality of Life and Current Treatment Patterns in Patients with Primary Biliary Cholangitis
Background and AimsPatients with primary biliary cholangitis (PBC) often suffer with pruritus. We describe the impact of pruritus on quality of life...
